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Compare Spikevax vs. Comirnaty

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Spikevax
    Comirnaty
  • Spikevax
    Comirnaty

  • Summary of Spikevax vs. Comirnaty

    Summary for mRNA vaccine
    Prescription only

    Spikevax (Moderna COVID-19 vaccine) is an mRNA vaccine. It's used to prevent infection from the virus that causes COVID-19. Spikevax is FDA approved for people ages 65 years and older. It's also approved for people ages 6 months to 64 years with at least one risk factor for serious problems from COVID. This vaccine is given by a healthcare professional as an injection into the muscle. Most people only need 1 dose of the updated Spikevax booster shot for the year, except for babies who've never been vaccinated before. Side effects include pain at the injection site, muscle pain, and tiredness.

    Summary for mRNA vaccine
    Prescription only

    Comirnaty (Pfizer COVID-19 vaccine) is an mRNA vaccine that's used to prevent infection from the virus that causes COVID-19. It's FDA approved for people 65 years and older, and for children and adults ages 5 to 64 years old who have at least one risk factor for severe COVID. The vaccine is given as a single booster shot into the muscle by a healthcare professional. Common side effects include pain at the injection site, tiredness, headache, and chills.

  • Indications of Spikevax vs. Comirnaty

    Indications for
    •Prevention of COVID-19 infection in people 65 years of age and older
    •Prevention of COVID-19 infection in people between 6 months and 64 years old with at least one condition that puts them at high risk of serious problems from illness
    Indications for
    •Prevention of COVID-19 infection in people 65 years of age and older
    •Prevention of COVID-19 infection in people ages 5 to 64 years old with at least one condition that puts them at high risk of serious problems from illness

  • Pros and Cons of Spikevax vs. Comirnaty

    Pros and Const for mRNA vaccine
    Pros
    •Usually need just 1 updated shot each year
    •Approved for older adults and certain people 6 months and older
    Cons
    •Doesn't guarantee that you won't get COVID (but helps prevent you from getting seriously sick)
    •Often causes temporary pain at the injection site, muscle pain, and tiredness
    Pros and Const for mRNA vaccine
    Pros
    •Only need 1 shot to be fully vaccinated
    •Approved for older adults and certain people 5 years and older
    Cons
    •Doesn't guarantee that you won't get COVID-19 (but helps lessen severity)
    •Commonly causes temporary pain at injection site, fever, and tiredness

  • Common Side Effects of Spikevax vs. Comirnaty

    Common Side Effects for
    •Pain at the injection site
    •Feeling tired
    •Headache
    •Muscle pain
    •Joint pain
    •Chills
    •Swelling or tenderness of lymph nodes in the armpit of the injected arm
    Common Side Effects for

    People 12 years and older:

    •Pain at the injection site (up to 91%)
    •Tiredness (up to 78%)
    •Headache (up to 76%)
    •Chills (up to 50%)
    •Muscle pain (up to 46%)
    •Joint pain (up to 28%)
    •Fever (up to 24%)
    •Swelling at the injection site (up to 12%)
    •Redness at the injection site (up to 10%)

    People ages 5 to 11 years old:

    •Pain at the injection site (up to 84%)
    •Tiredness (up to 52%)
    •Headache (up to 38%)
    •Redness at the injection site (up to 26%)
    •Swelling at the injection site (up to 20%)
    •Muscle pain (up to 18%)
    •Chills (up to 13%)
    •Fever (up to 8%)
    •Joint pain (up to 8%)

  • Warnings of Spikevax vs. Comirnaty

    Common Side Effects for
    •Heart inflammation (swelling)
    •Possible fainting after vaccination
    •Lowered response to Spikevax in people with a weakened immune system
    Common Side Effects for
    •Heart inflammation (swelling)
    •Possible fainting after vaccination
    •Lowered response to Comirnaty in people with weakened immune systems

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