Key takeaways
Guaifenesin ER (Mucinex) and dextromethorphan (Delsym) are both over-the-counter medications used to treat coughs, but they work in different ways and are used for different types of coughs. Guaifenesin ER is an expectorant that helps loosen and thin mucus in your airways, making it easier to cough up phlegm. It's typically taken every 12 hours and is suitable for adults and children 12 years and older. On the other hand, dextromethorphan is a cough suppressant that works by reducing the activity in the part of your brain that triggers coughing, making it effective for dry coughs. It comes in both extended-release and immediate-release forms, with dosing intervals ranging from every 6 to 12 hours depending on the formulation. While guaifenesin ER is generally well-tolerated with few side effects, dextromethorphan can sometimes cause drowsiness and has a risk of misuse and overdose. Both medications are available in generic forms and are found in many over-the-counter products, so it's important to avoid taking multiple medications with the same active ingredients.
