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Compare Lodine vs. Celecoxib

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Etodolac
    Celebrex (celecoxib)
  • Etodolac
    Celebrex (celecoxib)

  • Summary of Lodine vs. Celecoxib

    Summary for NSAID
    Prescription only

    Etodolac, also known by its brand name Lodine, is a non-steroidal anti-inflammatory drug (NSAID). The immediate-release pills are taken throughout the day; they're approved for adults with sudden, short-term pain; rheumatoid arthritis; or osteoarthritis. There's also an extended-release tablet for people ages 6 years and older that's taken once per day for the same types of arthritis. Side effects can include stomach pain, dizziness, and rash. Etodolac is currently available by prescription as generic only; the brand name has been discontinued.

    Summary for COX-2 selective NSAID
    Prescription only

    Celecoxib, also known by the brand name Celebrex, is a prescription pain medication that's used to temporarily relieve aches and pains from certain conditions, such as different types of arthritis. Celebrex (celecoxib) is a non-steroidal anti-inflammatory drug (NSAID), but it has a lower risk of causing stomach upset than other medications in its drug class, such as naproxen. The dosage for Celebrex (celecoxib) is typically once or twice a day. It's recommended to avoid taking this medication with alcohol since it can raise your risk for stomach bleeding. Other side effects include headache, indigestion, and diarrhea.

  • Indications of Lodine vs. Celecoxib

    Indications for
    •Osteoarthritis (OA)
    •Rheumatoid arthritis (RA)
    •Juvenile idiopathic arthritis - extended-release only
    •Short-term pain - immediate-release only
    Indications for
    •Osteoarthritis (OA)
    •Rheumatoid arthritis (RA)
    •Juvenile rheumatoid arthritis (JRA)
    •Ankylosing spondylitis (AS)
    •Sudden pain
    •Menstrual cramps

  • Pros and Cons of Lodine vs. Celecoxib

    Pros and Const for NSAID
    Pros
    •Works well to treat pain and inflammation
    •Extended-release tablets can be used for children as young as 6 years old
    •Available as a lower-cost generic
    Cons
    •Only available as pills that can't be split, open, or crushed
    •Not safe to take after 20 weeks of pregnancy
    •Might not be the best option if you're 65 years or older or if you have kidney, heart, liver, or bleeding problems
    Pros and Const for COX-2 selective NSAID
    Pros
    •Can use for different types of arthritis
    •Fewer stomach side effects compared to some other NSAIDs
    •Safe to take for children 2 years and older with RA
    •Can open capsules and mix contents with applesauce, so it's convenient for people with difficulty swallowing pills
    Cons
    •Can raise the risk of heart attack and stroke
    •Not recommended during second and third trimesters of pregnancy
    •Not recommended for use if you have severe liver disease
    •Might not be safe for people with a sulfa allergy

  • Common Side Effects of Lodine vs. Celecoxib

    Common Side Effects for

    The following side effects were reported in 1% to 10% of people who took etodolac:

    •Stomach pain
    •Indigestion or heartburn
    •Nausea
    •Vomiting
    •Constipation
    •Diarrhea
    •Passing gas
    •Stomach ulcer
    •Stomach bleeding
    •Swelling
    •Headache
    •Ringing in the ears
    •Itching
    •Rash
    •Anemia (low red blood cell count)
    •Elevated liver enzymes
    Common Side Effects for

    Adults

    •Headache (16%)
    •Indigestion (9%)
    •Upper respiratory infection (8%)
    •Diarrhea (6%)
    •Sinus infection (congestion, runny nose; 5%)
    •Belly pain (4%)

    Children

    •Headache (13%)
    •Fever (8%)
    •Belly pain (4-8%)
    •Cough (7%)
    •Nausea (7%)
    •Diarrhea (5%)
    •Common cold (stuffy nose, sneezing; 5%)

  • Warnings of Lodine vs. Celecoxib

    Common Side Effects for
    •Stomach bleeding
    •Heart attack and stroke
    •High blood pressure and heart failure
    •Kidney damage
    •Liver problems
    •Severe allergic reactions and skin reactions
    •Not safe to take while pregnant
    •Risk for bleeding
    Common Side Effects for
    •Heart attack and stroke
    •Stomach bleeding and ulcers
    •Liver problems
    •High blood pressure and heart failure
    •Kidney damage and high potassium levels
    •Severe allergic reactions
    •Severe asthma attack
    •Harm to unborn babies

  • Prices with our coupons for Lodine vs. Celecoxib

    Learn more about Etodolac
    Learn more about Celebrex

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