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Lodine vs. Celecoxib

Etodolac, also known by its brand name Lodine, is a non-steroidal anti-inflammatory drug (NSAID). The immediate-release pills are taken throughout the day; they're approved for adults with sudden, short-term pain; rheumatoid arthritis; or osteoarthritis. There's also an extended-release tablet for people ages 6 years and older that's taken once per day for the same types of arthritis. Side effects can include stomach pain, dizziness, and rash. Etodolac is currently available by prescription as generic only; the brand name has been discontinued.

• Osteoarthritis (OA)
• Rheumatoid arthritis (RA)
• Juvenile idiopathic arthritis - extended-release only
• Short-term pain - immediate-release only

The following side effects were reported in 1% to 10% of people who took etodolac:

• Stomach pain
• Indigestion or heartburn
• Nausea
• Vomiting
• Constipation
• Diarrhea
• Passing gas
• Stomach ulcer
• Stomach bleeding
• Swelling
• Headache
• Ringing in the ears
• Itching
• Rash
• Anemia (low red blood cell count)
• Elevated liver enzymes

• Stomach bleeding
• Heart attack and stroke
• High blood pressure and heart failure
• Kidney damage
• Liver problems
• Severe allergic reactions and skin reactions
• Not safe to take while pregnant
• Risk for bleeding

Celecoxib, also known by the brand name Celebrex, is a prescription pain medication that's used to temporarily relieve aches and pains from certain conditions, such as different types of arthritis. Celebrex (celecoxib) is a non-steroidal anti-inflammatory drug (NSAID), but it has a lower risk of causing stomach upset than other medications in its drug class, such as naproxen. The dosage for Celebrex (celecoxib) is typically once or twice a day. It's recommended to avoid taking this medication with alcohol since it can raise your risk for stomach bleeding. Other side effects include headache, indigestion, and diarrhea.

• Osteoarthritis (OA)
• Rheumatoid arthritis (RA)
• Juvenile rheumatoid arthritis (JRA)
• Ankylosing spondylitis (AS)
• Sudden pain
• Menstrual cramps

Adults

• Headache (16%)
• Indigestion (9%)
• Upper respiratory infection (8%)
• Diarrhea (6%)
• Sinus infection (congestion, runny nose; 5%)
• Belly pain (4%)

Children

• Headache (13%)
• Fever (8%)
• Belly pain (4-8%)
• Cough (7%)
• Nausea (7%)
• Diarrhea (5%)
• Common cold (stuffy nose, sneezing; 5%)

• Heart attack and stroke
• Stomach bleeding and ulcers
• Liver problems
• High blood pressure and heart failure
• Kidney damage and high potassium levels
• Severe allergic reactions
• Severe asthma attack
• Harm to unborn babies