Kombiglyze XR vs. Janumet for Diabetes Type 2: Important Differences and Potential Risks.

Kombiglyze XR

Janumet

(sitagliptin / metformin)

Summary for Kombiglyze XR

Prescription only

Kombiglyze XR is a combination diabetes medication for adults with Type 2 diabetes. It contains two active ingredients: saxagliptin and metformin. Kombiglyze XR works best to improve blood sugar levels when it's used along with a balanced diet and exercise routine. The extended-release tablet is taken by mouth once each day in the evening with a meal. The dosage depends on the other diabetes medications you might be taking. Side effects include diarrhea, nausea, and headache.

Indications for Kombiglyze XR

Type 2 diabetes

Pros and Cons for Kombiglyze XR

Pros

Combines two diabetes medications into a single pill for convenience
Taken by mouth once per day
Not likely to cause weight gain
Low risk of low blood sugar (hypoglycemia) when taken by itself

Cons

Harder to customize the dose of each active ingredient because it's a combination medication
Risk of lactic acidosis
Not a good option for people with severe kidney problems
Not for people with Type 1 diabetes or diabetic ketoacidosis

Common Side Effects for Kombiglyze XR

Headache (8%)
Nose and throat irritation (7%)

Warnings for Kombiglyze XR

Lactic acidosis
Inflammation of pancreas (pancreatitis)
Risk of heart failure
Low vitamin B12 levels
Low blood sugar levels (hypoglycemia) when taken with other diabetes medications
Joint pain
Serious allergic reactions
Severe skin reaction

Summary for Janumet

Prescription only

Janumet (sitagliptin / metformin) is a medication for adults with Type 2 diabetes. It contains two different diabetes medications that work together to help control blood sugar. One is sitagliptin, a DPP-4 inhibitor, and the other is metformin, a biguanide. The Janumet immediate-release tablets are taken by mouth twice a day. It works best when used with a balanced meal plan and exercise routine. Some side effects are diarrhea, upper respiratory tract infection, and headache. There's only a brand-name version of Janumet; there's no generic version yet.

Indications for Janumet

Type 2 diabetes

Pros and Cons for Janumet

Pros

Combines the effects of two diabetes medications into one tablet
Less likely to cause weight gain and low blood sugar compared to other diabetes medications
Can lower A1C by up to 2% in 6 months

Cons

Must take twice a day with meals
Only available as a fixed dose, so can be hard to make dose adjustments
Not a good option for people with severe kidney problems
Not approved for people with Type 1 diabetes

Common Side Effects for Janumet

Diarrhea (8%)
Upper respiratory tract infection (6%)
Headache (6%)

Warnings for Janumet

Lactic acidosis
Inflammation of the pancreas (pancreatitis)
Risk of heart failure
Sudden kidney problems
Low vitamin B12 levels
Low blood sugar (hypoglycemia) when taken with certain diabetes medications
Joint pain
Severe skin reaction
Serious allergic reactions

Prices with our coupons for Kombiglyze XR vs. Janumet

Saxagliptin/Metformin ER60 tablets / 2.5mg/1000mg

$123.22$295.43

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Sitagliptin/Metformin (Janumet)60 tablets / 50mg/1000mg

$53.13$315.60

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Kombiglyze XR vs. Janumet

Kombiglyze XR

Janumet

Summary for Kombiglyze XR

Indications for Kombiglyze XR

Pros and Cons for Kombiglyze XR

Pros

Cons

Common Side Effects for Kombiglyze XR

Warnings for Kombiglyze XR

Summary for Janumet

Indications for Janumet

Pros and Cons for Janumet

Pros

Cons

Common Side Effects for Janumet

Warnings for Janumet

Prices with our coupons for Kombiglyze XR vs. Janumet

Browse medications by letter

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Kombiglyze XR

Janumet

Summary for Kombiglyze XR

Indications for Kombiglyze XR

Pros and Cons for Kombiglyze XR

Pros

Cons

Common Side Effects for Kombiglyze XR

Warnings for Kombiglyze XR

Summary for Janumet

Indications for Janumet

Pros and Cons for Janumet

Pros

Cons

Common Side Effects for Janumet

Warnings for Janumet