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Compare Kombiglyze XR vs. Janumet

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Kombiglyze xr
    Janumet (sitagliptin / metformin)
  • Kombiglyze xr
    Janumet (sitagliptin / metformin)

  • Summary of Kombiglyze XR vs. Janumet

    Summary for DPP4 inhibitor / Biguanide
    Prescription only

    Kombiglyze XR is a combination diabetes medication for adults with Type 2 diabetes. It contains two active ingredients: saxagliptin and metformin. Kombiglyze XR works best to improve blood sugar levels when it's used along with a balanced diet and exercise routine. The extended-release tablet is taken by mouth once each day in the evening with a meal. The dosage depends on the other diabetes medications you might be taking. Side effects include diarrhea, nausea, and headache.

    Summary for DPP-4 inhibitor / Biguanide
    Prescription only

    Janumet (sitagliptin / metformin) is a medication for adults with Type 2 diabetes. It contains two different diabetes medications that work together to help control blood sugar. One is sitagliptin, a DPP-4 inhibitor, and the other is metformin, a biguanide. The Janumet immediate-release tablets are taken by mouth twice a day. It works best when used with a balanced meal plan and exercise routine. Some side effects are diarrhea, upper respiratory tract infection, and headache. There's only a brand-name version of Janumet; there's no generic version yet.

  • Indications of Kombiglyze XR vs. Janumet

    Indications for
    •Type 2 diabetes
    Indications for
    •Type 2 diabetes

  • Pros and Cons of Kombiglyze XR vs. Janumet

    Pros and Const for DPP4 inhibitor / Biguanide
    Pros
    •Combines two diabetes medications into a single pill for convenience
    •Taken by mouth once per day
    •Not likely to cause weight gain
    •Low risk of low blood sugar (hypoglycemia) when taken by itself
    Cons
    •Harder to customize the dose of each active ingredient because it's a combination medication
    •Risk of lactic acidosis
    •Not a good option for people with severe kidney problems
    •Not for people with Type 1 diabetes or diabetic ketoacidosis
    Pros and Const for DPP-4 inhibitor / Biguanide
    Pros
    •Combines the effects of two diabetes medications into one tablet
    •Less likely to cause weight gain and low blood sugar compared to other diabetes medications
    •Can lower A1C by up to 2% in 6 months
    Cons
    •Must take twice a day with meals
    •Only available as a fixed dose, so can be hard to make dose adjustments
    •Not a good option for people with severe kidney problems
    •Not approved for people with Type 1 diabetes

  • Common Side Effects of Kombiglyze XR vs. Janumet

    Common Side Effects for
    •Headache (8%)
    •Nose and throat irritation (7%)
    Common Side Effects for
    •Diarrhea (8%)
    •Upper respiratory tract infection (6%)
    •Headache (6%)

  • Warnings of Kombiglyze XR vs. Janumet

    Common Side Effects for
    •Lactic acidosis
    •Inflammation of pancreas (pancreatitis)
    •Risk of heart failure
    •Low vitamin B12 levels
    •Low blood sugar levels (hypoglycemia) when taken with other diabetes medications
    •Joint pain
    •Serious allergic reactions
    •Severe skin reaction
    Common Side Effects for
    •Lactic acidosis
    •Inflammation of the pancreas (pancreatitis)
    •Risk of heart failure
    •Sudden kidney problems
    •Low vitamin B12 levels
    •Low blood sugar (hypoglycemia) when taken with certain diabetes medications
    •Joint pain
    •Severe skin reaction
    •Serious allergic reactions

  • Prices with our coupons for Kombiglyze XR vs. Janumet

    Learn more about Kombiglyze xr
    Learn more about Janumet

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