Kombiglyze XR
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Janumet
(sitagliptin / metformin)
Get free couponsSummary for Kombiglyze XR
Kombiglyze XR is a combination diabetes medication for adults with Type 2 diabetes. It contains two active ingredients: saxagliptin and metformin. Kombiglyze XR works best to improve blood sugar levels when it's used along with a balanced diet and exercise routine. The extended-release tablet is taken by mouth once each day in the evening with a meal. The dosage depends on the other diabetes medications you might be taking. Side effects include diarrhea, nausea, and headache.
Indications for Kombiglyze XR
Pros and Cons for Kombiglyze XR
Pros
- Combines two diabetes medications into a single pill for convenience
- Taken by mouth once per day
- Not likely to cause weight gain
- Low risk of low blood sugar (hypoglycemia) when taken by itself
Cons
- Harder to customize the dose of each active ingredient because it's a combination medication
- Risk of lactic acidosis
- Not a good option for people with severe kidney problems
- Not for people with Type 1 diabetes or diabetic ketoacidosis
Common Side Effects for Kombiglyze XR
- Headache (8%)
- Nose and throat irritation (7%)
Warnings for Kombiglyze XR
- Lactic acidosis
- Inflammation of pancreas (pancreatitis)
- Risk of heart failure
- Low vitamin B12 levels
- Low blood sugar levels (hypoglycemia) when taken with other diabetes medications
- Joint pain
- Serious allergic reactions
- Severe skin reaction
Summary for Janumet
Janumet (sitagliptin / metformin) is a medication for adults with Type 2 diabetes. It contains two different diabetes medications that work together to help control blood sugar. One is sitagliptin, a DPP-4 inhibitor, and the other is metformin, a biguanide. The Janumet immediate-release tablets are taken by mouth twice a day. It works best when used with a balanced meal plan and exercise routine. Some side effects are diarrhea, upper respiratory tract infection, and headache. There's only a brand-name version of Janumet; there's no generic version yet.
Indications for Janumet
Pros and Cons for Janumet
Pros
- Combines the effects of two diabetes medications into one tablet
- Less likely to cause weight gain and low blood sugar compared to other diabetes medications
- Can lower A1C by up to 2% in 6 months
Cons
- Must take twice a day with meals
- Only available as a fixed dose, so can be hard to make dose adjustments
- Not a good option for people with severe kidney problems
- Not approved for people with Type 1 diabetes
Common Side Effects for Janumet
- Diarrhea (8%)
- Upper respiratory tract infection (6%)
- Headache (6%)
Warnings for Janumet
- Lactic acidosis
- Inflammation of the pancreas (pancreatitis)
- Risk of heart failure
- Sudden kidney problems
- Low vitamin B12 levels
- Low blood sugar (hypoglycemia) when taken with certain diabetes medications
- Joint pain
- Severe skin reaction
- Serious allergic reactions
Prices with our coupons for Kombiglyze XR vs. Janumet
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