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Compare Ibrance vs. Verzenio

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Ibrance (palbociclib)
    Verzenio (abemaciclib)
  • Ibrance (palbociclib)
    Verzenio (abemaciclib)

  • Summary of Ibrance vs. Verzenio

    Summary for Kinase inhibitor
    Prescription only

    Ibrance (palbociclib) is an oral medication used to treat certain types of advanced or metastatic breast cancer (cancer that has spread to other parts of the body). It works by stopping the uncontrolled growth of cancer cells. Ibrance (palbociclib) is taken once a day for 21 days in a 28 day cycle. But it should be used in combination with other medications that block or lower the amount of estrogen in your body.

    Summary for Cyclin-dependent kinase (CDK) inhibitor
    Prescription only

    Verzenio (abemaciclib) is a cyclin-dependent kinase (CDK) inhibitor. It’s a targeted therapy used to treat HR+/HER2- breast cancer, including early and advanced or metastatic breast cancer. Verzenio (abemaciclib) is sometimes taken alone and sometimes along with hormone therapy, depending on the stage of cancer. It comes as a pill that’s taken by mouth twice a day. Some of the more common side effects of Verzenio (abemaciclib) include nausea, diarrhea, and fatigue. Verzenio (abemaciclib) is only available as a brand-name medication.

  • Indications of Ibrance vs. Verzenio

    Indications for
    •HR+/HER2- advanced or metastatic breast cancer
    Indications for

    HR+/HER2- breast cancer:

    •Early breast cancer in people with a high risk of their cancer coming back
    •Advanced or metastatic breast cancer

  • Pros and Cons of Ibrance vs. Verzenio

    Pros and Const for Kinase inhibitor
    Pros
    •Available as a pill that’s swallowed once a day
    •Recommended treatment option for breast cancer HR+, HER- advanced or metastatic breast cancer
    •Compared with other similar medications, causes less diarrhea and has lower risk of affecting your heart rhythm
    Cons
    •Only available as a brand medication so it might be expensive
    •Can cause infections, some of which can be serious
    •Not safe to take while pregnant or breastfeeding
    Pros and Const for Cyclin-dependent kinase (CDK) inhibitor
    Pros
    •First-choice treatment option for metastatic breast cancer and for certain early breast cancers
    •Comes as a pill so it’s more convenient than an injection
    •Can be taken with or without food
    Cons
    •Taken twice a day
    •Only available as a brand-name medication
    •Commonly causes diarrhea

  • Common Side Effects of Ibrance vs. Verzenio

    Common Side Effects for
    •Infection (up to 60%)
    •Low white blood cell counts (up to 83%)
    •Tiredness (up to 41%)
    •Nausea (up to 35%)
    •Hair loss (up to 33%)
    •Swollen or sore mouth (up to 30%)
    •Low red blood cell count (anemia) (up to 30%)
    •Diarrhea (up to 26%)
    •Low platelet counts (up to 23%)

    Side effects listed were reported when Ibrance (palbociclib) was taken at the same time as letrozole (Femara) or fulvestrant (Faslodex).

    Common Side Effects for
    •Signs of stress to the kidney on blood tests (up to 99%)
    •Diarrhea (up to 90%)
    •Lower blood cell counts (up to 91%)
    •Tiredness (up to 65%)
    •Nausea (up to 64%)
    •Infection (up to 51%)
    •Signs of stress to the liver on lab tests (up to 31%)
    •Lower appetite (up to 45%)
    •Stomach pain (up to 39%)
    •Vomiting (up to 35%)
    •Hair loss (up to 27%)
    •Headache (up to 20%)

    *Note: Side effect information taken from a study of Verzenio (abemaciclib) by itself for metastatic breast cancer. *

  • Warnings of Ibrance vs. Verzenio

    Common Side Effects for
    •Low white blood cell counts
    •Lung problems
    •Harm to unborn baby
    Common Side Effects for
    •Diarrhea
    •Low white blood cell counts
    •Lung problems
    •Liver problems
    •Blood clots
    •Harm to unborn baby

  • Prices with our coupons for Ibrance vs. Verzenio

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