Key takeaways
Hydromet (hydrocodone/homatropine) and benzonatate (Tessalon Perles) are both used to relieve cough, but they work in different ways and have different risks. Hydromet is a combination of an opioid (hydrocodone) and an anticholinergic (homatropine), making it a controlled substance with a high risk of addiction and serious side effects like trouble breathing. It's taken by mouth every 6 hours as needed and is available as a generic. On the other hand, benzonatate is an antitussive that numbs the nerves in your lungs and airways to reduce the urge to cough. It’s not a controlled substance and is taken three times a day as needed. Benzonatate can cause drowsiness and should be swallowed whole to avoid numbing your mouth and throat. While Hydromet can be habit-forming and is not recommended for children under 6, benzonatate is not habit-forming but should not be used by children under 10. Both medications are available in generic forms and should be used under the guidance of a healthcare provider.
