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Effexor XR vs. Xanax

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Venlafaxine (Effexor) and alprazolam (Xanax) are both used to treat anxiety, but they belong to different medication classes and have distinct uses and effects. Venlafaxine is a serotonin and norepinephrine reuptake inhibitor (SNRI) that also treats depression, social anxiety disorder, and panic disorder. It works by increasing serotonin and norepinephrine levels in the brain. Alprazolam, on the other hand, is a benzodiazepine that is used for generalized anxiety disorder (GAD) and panic disorder. It acts quickly to relax your mood by affecting certain brain chemicals. Venlafaxine is available in both immediate-release and extended-release forms, while Alprazolam is typically taken three times a day and is meant for short-term use due to its risk of dependence. Venlafaxine can cause severe withdrawal symptoms if stopped abruptly, whereas Alprazolam can lead to addiction and withdrawal symptoms if used long-term. Additionally, Venlafaxine is not a controlled substance, while Alprazolam is a Schedule IV controlled medication. Both medications have common side effects, but Alprazolam is more likely to cause drowsiness and memory problems, while Venlafaxine may cause nausea and fatigue.

Venlafaxine

 

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Alprazolam

(Xanax)

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Summary for Effexor XR

Prescription only

Venlafaxine is an antidepressant used to treat mental health conditions like depression, generalized anxiety disorder, social anxiety disorder, and panic disorder. It comes in two forms: extended-release, which is taken once a day, and immediate-release, which is taken in split doses throughout the day. This medication can interact with many things, including other medications and alcohol. Possible side effects can include nausea, weight changes, and sexual problems. It can also cause withdrawal symptoms if you stop taking it suddenly.

Indications for Effexor XR

Pros and Cons for Effexor XR

Pros

  • Can treat multiple mental health conditions
  • Affects two chemicals in the brain that impact your mood
  • Lower risk of weight gain compared to other antidepressants
  • Comes in both immediate-release and extended-release versions

Cons

  • Might raise your blood pressure, especially at higher doses
  • Interacts with many medications
  • Can take up to 4 to 8 weeks before you feel the full effect
  • High risk of causing withdrawal symptoms if suddenly stopped

Common Side Effects for Effexor XR

Extended-release:

  • Nausea (29-31%)
  • Trouble sleeping (17-23%)
  • Dizziness (16-20%)
  • Loss of appetite (10-20%)
  • Drowsiness (15-17%)
  • Dry mouth (12-17%)
  • Abnormal ejaculation (10-16%)
  • Sweating (11-14%)
  • Weakness (8-13%)

Immediate-release:

  • Nausea (37%)
  • Headache (25%)
  • Drowsiness (23%)
  • Dry mouth (22%)
  • Dizziness (19%)
  • Trouble sleeping (18%)
  • Constipation (15%)
  • Nervousness (13%)
  • Weakness (12%)
  • Sweating (12%)
  • Abnormal ejaculation (12%)
  • Loss of appetite (11%)

Warnings for Effexor XR

  • Suicidal thoughts and behavior
  • Serotonin syndrome
  • High blood pressure
  • Higher bleeding risk
  • Mania
  • Glaucoma
  • Withdrawal
  • Seizures
  • Low sodium levels
  • Lung problems and pneumonia
  • Sexual problems

Summary for Xanax

Prescription only

Alprazolam (Xanax) is a benzodiazepine. It's approved to treat generalized anxiety disorder (GAD) and panic attacks in adults. It's taken by mouth, typically 3 times a day or as directed by your healthcare team. To avoid the risk of dependence, alprazolam (Xanax) is meant for short-term treatment only. Some of the more common side effects of this medication include drowsiness and memory problems. You should avoid drinking alcohol while taking alprazolam (Xanax) because this can lead to serious interactions.

Indications for Xanax

Pros and Cons for Xanax

Pros

  • Taken by mouth
  • Can start to work in 30 minutes
  • Available as quick-dissolving tablets or liquid for people who have trouble swallowing pills

Cons

Common Side Effects for Xanax

Generalized anxiety disorder:

  • Drowsiness (41%)
  • Lightheadedness (21%)
  • Dry mouth (15%)

Panic disorder:

  • Drowsiness (77%)
  • Fatigue (49%)
  • Poor coordination (40%)
  • Memory issues (33%)
  • Irritability (33%)
  • Appetite changes (28-33%)
  • Thinking problems (29%)
  • Constipation (26%)

Side effects listed are for the immediate-release forms. Side effects for extended-release form might differ.

Warnings for Xanax

  • Sedation and difficulty breathing
  • Potential for misuse, addiction, dependence, and withdrawal
  • Effect on driving and concentration
  • Harm to babies
  • Interactions with other medications
  • Use with caution in people with depression

Prices with our coupons for Effexor XR vs. Xanax

Price Card Drug Icon
Venlafaxine90 tablets / 75mg
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Alprazolam30 tablets / 0.5mg
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