Head-to-head comparisons of medication uses, side effects, warnings, and more.
Comirnaty
Spikevax
Comirnaty
Spikevax
Summary of Comirnaty vs. Spikevax
Summary for mRNA vaccine
Prescription only
Comirnaty (Pfizer COVID-19 vaccine) is an mRNA vaccine that's used to prevent infection from the virus that causes COVID-19. It's FDA approved for people 65 years and older, and for children and adults ages 5 to 64 years old who have at least one risk factor for severe COVID. The vaccine is given as a single booster shot into the muscle by a healthcare professional. Common side effects include pain at the injection site, tiredness, headache, and chills.
Summary for mRNA vaccine
Prescription only
Spikevax (Moderna COVID-19 vaccine) is an mRNA vaccine. It's used to prevent infection from the virus that causes COVID-19. Spikevax is FDA approved for people ages 65 years and older. It's also approved for people ages 6 months to 64 years with at least one risk factor for serious problems from COVID. This vaccine is given by a healthcare professional as an injection into the muscle. Most people only need 1 dose of the updated Spikevax booster shot for the year, except for babies who've never been vaccinated before. Side effects include pain at the injection site, muscle pain, and tiredness.
Indications of Comirnaty vs. Spikevax
Indications for
•Prevention of COVID-19 infection in people 65 years of age and older
•Prevention of COVID-19 infection in people ages 5 to 64 years old with at least one condition that puts them at high risk of serious problems from illness
Indications for
•Prevention of COVID-19 infection in people 65 years of age and older
•Prevention of COVID-19 infection in people between 6 months and 64 years old with at least one condition that puts them at high risk of serious problems from illness
Pros and Cons of Comirnaty vs. Spikevax
Pros and Const for mRNA vaccine
Pros
•Only need 1 shot to be fully vaccinated
•Approved for older adults and certain people 5 years and older
Cons
•Doesn't guarantee that you won't get COVID-19 (but helps lessen severity)
•Commonly causes temporary pain at injection site, fever, and tiredness
Pros and Const for mRNA vaccine
Pros
•Usually need just 1 updated shot each year
•Approved for older adults and certain people 6 months and older
Cons
•Doesn't guarantee that you won't get COVID (but helps prevent you from getting seriously sick)
•Often causes temporary pain at the injection site, muscle pain, and tiredness
Common Side Effects of Comirnaty vs. Spikevax
Common Side Effects for
People 12 years and older:
•Pain at the injection site (up to 91%)
•Tiredness (up to 78%)
•Headache (up to 76%)
•Chills (up to 50%)
•Muscle pain (up to 46%)
•Joint pain (up to 28%)
•Fever (up to 24%)
•Swelling at the injection site (up to 12%)
•Redness at the injection site (up to 10%)
People ages 5 to 11 years old:
•Pain at the injection site (up to 84%)
•Tiredness (up to 52%)
•Headache (up to 38%)
•Redness at the injection site (up to 26%)
•Swelling at the injection site (up to 20%)
•Muscle pain (up to 18%)
•Chills (up to 13%)
•Fever (up to 8%)
•Joint pain (up to 8%)
Common Side Effects for
•Pain at the injection site
•Feeling tired
•Headache
•Muscle pain
•Joint pain
•Chills
•Swelling or tenderness of lymph nodes in the armpit of the injected arm
Warnings of Comirnaty vs. Spikevax
Common Side Effects for
•Heart inflammation (swelling)
•Possible fainting after vaccination
•Lowered response to Comirnaty in people with weakened immune systems
Common Side Effects for
•Heart inflammation (swelling)
•Possible fainting after vaccination
•Lowered response to Spikevax in people with a weakened immune system
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