Ciclopirox (Loprox, Penlac) and Tavaborole (Kerydin) are both topical antifungals used to treat fungal infections, but they have some key differences. Ciclopirox is available in various forms, including cream, gel, shampoo, suspension, and nail lacquer, and it treats a wide range of fungal infections like jock itch, athlete's foot, and ringworm. Tavaborole, on the other hand, is specifically used for fungal toenail infections and is applied once daily for 48 weeks. Ciclopirox can take several months to show improvement for nail infections, while tavaborole also requires long-term use but is noted for being less effective overall. Tavaborole is available as a generic but can still be expensive, whereas ciclopirox is generally lower-cost. Both medications have few side effects, but tavaborole is flammable and should be kept away from heat and flames.