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Beyfortus vs. Abrysvo

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Beyfortus

(nirsevimab)

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Abrysvo

(RSV vaccine)

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Summary for Beyfortus

Prescription only

Beyfortus (nirsevimab or nirsevimab-alip) is an injection given to babies and children up to 24 months old. It's used to prevent them from getting very sick from respiratory syncytial virus (RSV). It's not an RSV vaccine. Instead, it's a monoclonal antibody that gives protection against the virus for a short time. Beyfortus (nirsevimab) is now part of the CDC Child Immunization Schedule. The usual dosage is 1 to 2 injections into the muscle during or at the start of the RSV season. It's well-tolerated with only a few side effects.

Indications for Beyfortus

  • Prevention of respiratory syncytial virus (RSV) in young children of certain ages
    • Newborns and infants born during or entering their first RSV season
    • Children up to 24 months old at risk of severe RSV illness through their second RSV season

Pros and Cons for Beyfortus

Pros

  • Given during one medical visit
  • Can lower the risk of severe RSV-related illness by about 70% in full-term and premature babies
  • Not many side effects

Cons

  • Injection can be uncomfortable
  • Protection might only last for about 5 months
  • Not known if it's safe or if it works well for children older than 24 months

Common Side Effects for Beyfortus

  • Side effects aren't common. See Other Side Effects.

Warnings for Beyfortus

  • Severe allergic reaction
  • Caution use in children with bleeding problems

Summary for Abrysvo

Prescription only

Abrysvo (RSV vaccine) is a vaccine that helps lower your risk of getting serious lung infections caused by respiratory syncytial virus (RSV). It's FDA approved for adults 60 years and older, and adults 18 to 59 years who have a higher risk of getting seriously ill from RSV. It's also approved for pregnant mothers between 32 and 36 weeks gestation to help protect their babies from RSV after birth. Abrysvo (RSV vaccine) is given as a single injection into the muscle. Common side effects include tiredness, headache, and injection site reactions like pain, swelling, or redness.

Indications for Abrysvo

Prevention of serious lung infections caused by respiratory syncytial virus (RSV) in:

  • Adults 60 years and older
  • Adults 18 to 59 years old who have a higher risk of illness due to RSV
  • Pregnant mothers between 32 to 36 weeks gestation

Pros and Cons for Abrysvo

Pros

  • Only need one dose
  • Protects both adults and newborns from serious RSV illness
  • Can be given with other vaccines

Cons

  • Injection might be uncomfortable
  • Not approved for people under 18 years old
  • Common side effects include tiredness and headache

Common Side Effects for Abrysvo

18 to 59 years old:

  • Tiredness (37%)
  • Pain at injection site (35%)
  • Headache (28%)
  • Muscle pain (24%)
  • Diarrhea (15%)
  • Joint pain (12%)
  • Nausea (12%)

60 years and older:

  • Tiredness (16%)
  • Headache (13%)
  • Pain at injection site (11%)
  • Muscle pain (10%)

Pregnant mothers:

  • Tiredness (46%)
  • Pain at injection site (41%)
  • Headache (31%)
  • Muscle pain (27%)
  • Nausea (20%)

Warnings for Abrysvo

  • Guillain‑Barré syndrome
  • Potential risk of preterm (early) birth
  • Severe allergic reaction
  • Fainting
  • Weaker vaccine protection

Prices with our coupons for Beyfortus vs. Abrysvo

Price Card Drug Icon
Beyfortus1 carton / five 0.5ml prefilled syringes of 50mg/0.5ml
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Abrysvo1 kit / 1 dose
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