Key takeaways
Addyi (flibanserin) and Vyleesi (bremelanotide) are both FDA-approved treatments for low sex drive in women who haven't gone through menopause yet, but they work differently and are used in different ways. Addyi is a serotonin receptor agonist/antagonist taken as a daily pill at bedtime, while Vyleesi is a melanocortin receptor agonist that you inject under the skin as needed, at least 45 minutes before sex. Addyi has alcohol restrictions due to the risk of low blood pressure and fainting, whereas Vyleesi does not have these alcohol limitations but can briefly raise blood pressure and lower heart rate. Common side effects of Addyi include dizziness, sleepiness, and nausea, while Vyleesi often causes nausea, flushing, and injection site reactions. Additionally, Addyi is available in a generic form, but Vyleesi is not.
