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Clonidine ER

Clonidine ER Side Effects

Robert Chad Hakim, PharmD, BCCCPAllison Gourley, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Allison Gourley, PharmD
Last reviewed on November 7, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Sleepiness (up to 38%)
  • Headache (up to 20%)
  • Fatigue (up to 16%)
  • Upper stomach pain (up to 15%)

Less Common Side Effects

  • Irritable
  • Dizziness
  • Trouble sleeping
  • Nightmare
  • Mood problems
  • Nausea
  • Low appetite

Clonidine ER serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe allergic reaction: trouble breathing; rash; swelling of the face, lips, tongue, or throat
  • Dangerously low blood pressure: lightheadedness, dizziness, feeling faint, tiredness, confusion

Source: DailyMed

The following Clonidine ER side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Mental depression

swelling of the feet and lower legs

Rare

Anxiety

blistering, burning, crusting, dryness, or flaking of the skin

chest pain or discomfort

confusion as to time, place, or person

decreased urine output

dilated neck veins

drowsiness

dry mouth

fast, pounding, or irregular heartbeat or pulse

fever

general feeling of discomfort or illness

holding false beliefs that cannot be changed by fact

hyperventilation

irregular breathing

irritability

itching, scaling, severe redness, soreness, or swelling of the skin

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

lightheadedness, dizziness, or fainting

mental depression

paleness or cold feeling in the fingertips and toes

pounding, slow heartbeat

problems in urination or increase in the amount of urine

raised red swellings on the skin, lips, tongue, or in the throat

restlessness

seeing or hearing things that are not there

shaking

shortness of breath

skin rash

swelling of the face, fingers, feet, or lower legs

tightness in the chest

tingling or pain in the fingers or toes when exposed to cold

trouble with sleeping

troubled breathing

unusual excitement, nervousness, or restlessness

unusual tiredness or weakness

vivid dreams or nightmares

weight gain

wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Dizziness (extreme) or faintness

feeling cold

pinpoint pupils of the eyes

unusual tiredness or weakness (extreme)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Constipation

Less common

Darkening of the skin

decreased sexual ability

dry, itching, or burning eyes

loss of appetite

nausea or vomiting

Rare

Blurred vision

decreased interest in sexual intercourse

hair loss or thinning of the hair

inability to have or keep an erection

leg cramps

loss in sexual ability, desire, drive, or performance

muscle or joint pain

pale skin

swelling of the breasts or breast soreness in both females and males

weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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