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Apraclonidine

Apraclonidine Side Effects

Kristianne Hannemann, PharmDDaisy Chau, PharmD
Reviewed by Kristianne Hannemann, PharmD, Daisy Chau, PharmD
Last reviewed on September 10, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Eye discomfort (5-15%)
  • Eye redness (5-15%)
  • Eye itching (5-15%)
  • Dry mouth (10%)

Less Common Side Effects

  • Blurred vision
  • Eye inflammation
  • Dry eye
  • Feeling like there's something in your eye
  • Eyelid changes
  • Tearing
  • Abnormal heartbeat
  • Stuffy nose

Source: DailyMed

The following Apraclonidine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

For 0.5% apraclonidine

More common

Allergic reaction (redness, itching, tearing of the eye)

Less common

Blurred vision or change in vision

chest pain

clumsiness or unsteadiness

depression

dizziness

eye discharge, irritation, or pain

irregular heartbeat

numbness or tingling in the fingers or toes

raising of the upper eyelid

rash around the eyes

redness of the eyelid or inner lining of the eyelid

swelling of the eye, eyelid, or inner lining of the eyelid

swelling of the face, hands, or feet

For 1% apraclonidine

Less common

Blurred vision

diarrhea

dry mouth

eye redness

fainting

feeling cold or sleepy

irregular heartbeat

lightheadedness

redness, swelling, or whitening of the eyelids

slow heartbeat

stomach pain

stuff or runny nose

swelling of the eyelid

trouble sleeping

unusual dreams

unusual taste in the mouth

vomiting

watering of eye

Get emergency help immediately if any of the following symptoms of overdose occur:

For 1% apraclonidine

Symptoms of overdose

Confusion

clumsiness

drowsiness

low body temperature

muscle aches

muscle weakness

shivering

sleepiness

slow heartbeat

tiredness

weak or feeble pulse

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For 0.5% apraclonidine

More common

Dryness of the mouth

eye discomfort

Less common

Change in taste or smell

constipation

crusting or scales on the eyelid or corner of the eye

discoloration of white part of the eye

drowsiness or sleepiness

dry nose or eyes

general feeling of discomfort or illness

headache

increased sensitivity of the eyes to light

muscle aches

nausea

nervousness

paleness of the eye or inner lining of the eyelid

runny nose

sore throat

tiredness or weakness

trouble in sleeping

For 1% apraclonidine

More common

Increase in size of the pupil of the eye

paleness of the eye or inner lining of the eyelid

Less common

Runny nose

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.
Daisy Chau, PharmD
Reviewed by:
Daisy Chau, PharmD
Daisy Chau, PharmD, is the drug information pharmacist manager at GoodRx. She is licensed in California and has more than 6 years of experience working as a pharmacist in drug information.

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