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Clobetasol

Clobetasol Side Effects

Kristianne Hannemann, PharmDCydnee Ng, PharmD
Reviewed by Kristianne Hannemann, PharmD, Cydnee Ng, PharmD
Last reviewed on October 23, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Burning
  • Stinging
  • Skin irritation
  • Itching

Less Common Side Effects

  • Dry skin
  • Skin redness
  • Thinning skin
  • Loose skin (loss of skin elasticity)
  • Acne-like bumps
  • Stretch marks
  • Lighter skin color
  • Hair loss (when used on the scalp)
When do Clobetasol possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Skin thinning
Stretch marks

Source: DailyMed

The following Clobetasol side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Burning or stinging at the application site

Less common

Burning sensation of the skin

dry skin

flushing or redness of the skin

itching, scaling, severe redness, soreness, or swelling of the skin

skin irritation

skin rash, encrusted, scaly and oozing

thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (eg, between the fingers)

Rare

Thinning, weakness, or wasting away of the skin

Incidence not known

Backache

blindness

blurred vision

burning, itching, and pain in hairy areas, or pus at the root of the hair

change in vision

dry mouth

eye pain

facial hair growth in females

fractures

fruit-like breath odor

full or round face, neck, or trunk

hair loss

headache

hives

increased hunger

increased thirst

increased urination

irritability

loss of sexual desire or ability

menstrual irregularities

muscle wasting

nausea

redness and scaling around the mouth

stomach pain

sugar in the urine

sweating

tearing

thinning of the hair

troubled breathing

unexplained weight loss

unusual tiredness or weakness

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Cough

sore throat

Less common

Body aches or pain

changes in skin coloring

congestion

dryness of the throat

raised, dark red, wart-like spots on the skin, especially when used on the face

skin discomfort

stuffy or runny nose

tender, swollen glands in the neck

trouble swallowing

voice changes

Incidence not known

Acne or pimples

burning and itching of the skin with pinhead-sized red blisters

increased hair growth on the forehead, back, arms, and legs

lightening of normal skin color

lightening of treated areas of dark skin

reddish purple lines on the arms, face, legs, trunk, or groin

softening of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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