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siRNAs

Small interfering ribonucleic acids are used to treat polyneuropathy caused by hereditary transthyretin-mediated amyloidosis. They also treat porphyria, high cholesterol, and various inherited metabolic conditions. They work by stopping the production of certain proteins that cause these medical conditions.

Why are sirnas prescribed?

High Cholesterol (100%)
Hemophilia (0%)
Inherited Metabolic Diseases (0%)
Hereditary Transthyretin-Mediated Amyloidosis (0%)
Porphyria (0%)

How are these percentages calculated?

Key takeaways

Small interfering RNAs (siRNAs) are used to treat conditions like hereditary transthyretin-mediated amyloidosis (hATTR), primary hyperoxaluria type 1 (PH1), and high cholesterol. They also have other uses, such as managing acute hepatic porphyria (AHP). siRNAs work by targeting and degrading specific RNA molecules, which prevents the production of disease-causing proteins. These medications are typically available as injections. Examples include Onpattro (patisiran), Givlaari (givosiran), and Leqvio (inclisiran).

Prices for popular siRNAs medications

Viewing 8 of 8 medications

Leqvio

INCLISIRAN treats high cholesterol. It works by decreasing bad cholesterol (such as LDL) in your blood. Changes to diet and exercise are often combined with this medication.

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Rivfloza

as low as$34,283

NEDOSIRAN treats high levels of the waste product oxalate in the urine, which can cause kidney stones and other problems. It works by decreasing the amount of oxalate your body makes.

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Amvuttra

Vutrisiran treats nerve pain, tingling, or numbness in the hands or feet in people with hereditary transthyretin-mediated amyloidosis (hATTR). It works by reducing the buildup of a protein in your body. This decreases the symptoms of hATTR.

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Givlaari

GIVOSIRAN treats porphyria, a condition that causes the buildup of toxins (porphyrins) in your body. It works by decreasing the amount of toxins in the body. This decreases symptoms such as pain, vomiting, and muscle weakness.

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Onpattro

Patisiran treats nerve pain, tingling, or numbness in the hands or feet in people with hereditary transthyretin-mediated amyloidosis (hATTR). It works by reducing the buildup of a protein in your body. This decreases the symptoms of hATTR.

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Oxlumo

LUMASIRAN lowers urinary oxalate levels in children and adults with primary hyperoxaluria type 1 (PH1).

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Qfitlia

Qfitlia is only available as a brand name drug.

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Redemplo

Redemplo is only available as a brand name drug.

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Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.