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Rivfloza Coupon - Rivfloza 0.5ml of 80mg/0.5ml vial

Rivfloza

nedosiran
Used for Inherited Metabolic Diseases
Used for Inherited Metabolic Diseases

Rivfloza (nedosiran) is an injectable medication that's used to lower oxalate levels in the urine in people 9 years and older with a rare inherited, genetic condition called primary hyperoxaluria type 1 (PH1). This medication belongs to the drug class called small interfering RNA (siRNA). It works to stop the liver from making oxalate. Rivfloza (nedosiran) is injected under the skin once a month. The most common side effect is having an injection site reaction. Rivfloza (nedosiran) is a brand-name medication; it isn't available as a lower-cost generic.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Allison Gourley, PharmD
Last reviewed on July 11, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsDosageCostAlternativesImagesReferencesPricesMedicare
basics-icon

What is Rivfloza (nedosiran)?

What is Rivfloza (nedosiran) used for?

How Rivfloza (nedosiran) works

People with primary hyperoxaluria type 1 (PH1) often have a buildup of oxalate in the urine. This can lead to kidney stones.

Rivfloza (nedosiran) is a type of small interfering RNA (siRNA). It targets lactate dehydrogenase A (LDHA), a protein found in liver cells that helps make oxalate.

This medication lessens the amount of LDHA in the liver, which then lessens the amount of oxalate that's made. This lessens how much oxalate your body gets rid of through the urine, which might help lower your risk of developing kidney stones and kidney problems.

Drug Facts

Common BrandsRivfloza
Drug ClasssiRNA
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Rivfloza (nedosiran)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Injection site reaction (e.g., redness, pain, bruising, rash; 39%)

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Pain, redness, irritation, or bruising at the injection site
pros-and-cons

Pros and cons of Rivfloza (nedosiran)

thumbs-up

Pros

Can give at home after you get trained on how to inject the medication yourself

Only need to take once per month

Available in a prefilled syringe for convenience

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Cons

Injections can be uncomfortable

Doesn't cure PH1; only helps to control symptoms

Not approved for children younger than 9 years old

pharmacist-tips

Pharmacist tips for Rivfloza (nedosiran)

pharmacist

  • Don't inject Rivfloza (nedosiran) at home until a healthcare professional has shown you or your caregiver how to inject it safely and properly. Read the Instructions for Use, and ask your prescriber or pharmacist if you have any questions.

    • Keep Rivfloza (nedosiran) in the refrigerator until you're ready to take your dose. If needed, you can keep the medication at room temperature in the original packaging for up to 28 days (4 weeks).

      • Before you inject Rivfloza (nedosiran), remove the medication from the refrigerator and let it sit out so it can reach room temperature. This can take about 30 minutes. Don't warm it up any other way because this could damage the medication.

        • Check that the medication inside of the vial or prefilled syringe is colorless to yellow and doesn't have any particles before you inject. Don't use the medication if it looks cloudy or contains particles, and contact your prescriber or pharmacist.

          Tips for injecting Rivfloza (nedosiran):

          • Wash your hands and clean the injection site (stomach or upper thigh) with an alcohol wipe. Let it dry, but don't blow on it or fan the area.

            • Pinch your skin with one hand, and insert the needle at a 45 degree angle with the other. Push the plunger of the syringe all the way down until the syringe is empty. Then, remove the syringe from the injection site.

              • Place the needle directly into a sharps container right after injecting. Don't put it in the regular trash because this can raise the risk for needle-stick injuries.

                • You can gently place a cotton ball or gauze over the injection site if there's a little blood.

                  faqs

                  Frequently asked questions about Rivfloza (nedosiran)

                  Can I inject Rivfloza (nedosiran) at home?
                  Depending on your age, you can take Rivfloza (nedosiran) at home after you or a caregiver gets trained by a healthcare professional (HCP) on how to inject it safely and properly. You can give the injection to yourself using the prefilled syringe if you're 12 years of age or older. A caregiver must help inject Rivfloza (nedosiran) for children ages 9 to 11 years old. You can also ask a trained HCP to administer the dose at the medical office if you aren't comfortable injecting the medication to yourself or for your child.
                  Where should I inject Rivfloza (nedosiran)?
                  You should inject Rivfloza (nedosiran) into the skin on your stomach (at least 2 inches from the belly button). You can also choose to inject the medication into the skin on your upper thigh. Don't inject this medication into a vein or skin that's bruised or scarred.
                  How well does Rivfloza (nedosiran) work?
                  In a clinical study of people who took Rivfloza (nedosiran), the medication lowered oxalate levels in the urine by almost an average of 40% over 6 months of treatment. In comparison, people who took a placebo (no active medication) had an average rise of 12% in oxalate levels in the urine over the same amount of time. Rivfloza (nedosiran) continued to lower oxalate levels in some people who took the medication for an additional 2.5 years of treatment. Your prescriber will periodically check the oxalate levels in your urine to see how well Rivfloza (nedosiran) is working for you.
                  What's the difference between Rivfloza (nedosiran) and Oxlumo (lumasiran)?
                  Both Rivfloza (nedosiran) and Oxlumo (lumasiran) are injectable medications that are used to lower oxalate levels in the urine in people with primary hyperoxaluria type 1 (PH1). One difference is that Rivfloza (nedosiran) is only approved for people who are 9 years and older but Oxlumo (lumasiran) can be used for all ages (including from birth). In addition, Rivfloza (nedosiran) is injected once monthly. On the other hand, Oxlumo (lumasiran) is injected once every 3 months after the first few doses for people who weigh more than 22 pounds. Talk to your prescriber to find out more about comparing between these two medications.
                  What should you do if you miss a dose of Rivfloza (nedosiran)?
                  Inject a dose of Rivfloza (nedosiran) as soon as you remember if you miss your dose. For your next dose, take your monthly dose as usual (the date of the month that you usually take the medication) if you miss your dose by 7 days or less. But if it's been more than 7 days, you'll need to wait a month after you take your missed dose to take your next one. Ask your care team if you're not sure what to do after you've missed a dose of Rivfloza (nedosiran).
                  Is Rivfloza (nedosiran) safe to take while pregnant or breastfeeding?
                  There isn't enough information to know whether Rivfloza (nedosiran) is safe to take during pregnancy. Similarly, the effects of Rivfloza (nedosiran) on breast milk or breastfed babies aren't known. Speak with a healthcare professional about the risks and benefits of the medication if you're pregnant or breastfeeding.
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                  dosage

                  Rivfloza (nedosiran) dosage forms

                  Typical dosing for Rivfloza (nedosiran)

                  Your dose of Rivfloza (nedosiran) will depend on your age and body weight.

                  • Adults and children ages 12 years and older

                    • Weigh 50 kg (110 lbs) or more: The typical dose is 160 mg injected under the skin once a month.

                    • Weigh less than 50 kg (110 lbs): The typical dose is 128 mg injected under the skin once a month.

                  • Children ages 9 to 11 years old

                    • Weigh 50 kg (110 lbs) or more: The typical dose is 160 mg injected under the skin once a month.

                    • Weigh less than 50 kg (110 lbs): The typical dose is 3.3 mg/kg of body weight (up to 128 mg) injected under the skin once a month.

                  drug-cost

                  How much does Rivfloza (nedosiran) cost?

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                  Rivfloza (brand)
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                  alternatives

                  What are alternatives to Rivfloza (nedosiran)?

                  There are a number of medications that your doctor can prescribe in place of Rivfloza (nedosiran). Compare a few possible alternatives below.
                  Rivfloza (nedosiran)
                  Used for:
                  $32260.94 Lowest GoodRx priceView Prices
                  Oxlumo (lumasiran)
                  Used for:

                  • Lower the oxalate levels in people with primary hyperoxaluria type 1 (PH1)

                  View Prices
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                  Rivfloza (nedosiran) images

                  yellow - Rivfloza 80mg / 0.5mL Single-Dose Vial Solution for Injection
                  This medicine is Yellow Vial.yellow - Rivfloza 80mg / 0.5mL Single-Dose Vial Solution for Injection

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                  References

                  Best studies we found

                  American Kidney Fund. (2024). Primary hyperoxaluria and oxalate: Symptoms, causes and treatment.

                  Fargue, S., et al. (2022). Primary hyperoxaluria type 1: Pathophysiology and genetics. Clinical Kidney Journal.

                  Groothoff, J., et al. (2024). Nedosiran safety and efficacy in PH1: Interim analysis of PHYOX3. Kidney International Reports.

                  View All References (5)

                  Liu, A., et al. (2022). Nedosiran, a candidate siRNA drug for the treatment of primary hyperoxaluria: Design, development, and clinical studies. American Chemical Society Pharmacology & Translational Science.

                  National Kidney Foundation. (n.d.). Calcium oxalate stones.

                  National Kidney Foundation. (2024). Primary hyperoxaluria type 1.

                  Novo Nordisk. (2023). Rivfloza- nedosiran injection, solution [package insert]. DailyMed.

                  Syed, Y. Y. (2023). Nedosiran: First approval. Drugs.

                  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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