Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Rivfloza vs. Oxlumo

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Rivfloza (nedosiran)
    Oxlumo (lumasiran)
  • Rivfloza (nedosiran)
    Oxlumo (lumasiran)

  • Summary of Rivfloza vs. Oxlumo

    Summary for siRNA
    Prescription only

    Rivfloza (nedosiran) is an injectable medication that's used to lower oxalate levels in the urine in people 9 years and older with a rare inherited, genetic condition called primary hyperoxaluria type 1 (PH1). This medication belongs to the drug class called small interfering RNA (siRNA). It works to stop the liver from making oxalate. Rivfloza (nedosiran) is injected under the skin once a month. The most common side effect is having an injection site reaction. Rivfloza (nedosiran) is a brand-name medication; it isn't available as a lower-cost generic.

    Summary for Small interfering ribonucleic acid (siRNA)
    Prescription only

    Oxlumo (lumasiran) is an injectable medication used to treat a rare condition called primary hyperoxaluria type 1 (PH1). This condition mainly affects the kidneys, but can also harm other organs. Oxlumo (lumasiran) doesn't have many side effects and is given every 1 or 3 months, depending on your weight.

  • Indications of Rivfloza vs. Oxlumo

    Indications for
    •To lower oxalate levels in the urine in people 9 years and older with primary hyperoxaluria type 1 (PH1)
    Indications for
    •Lower the oxalate levels in people with primary hyperoxaluria type 1 (PH1)

  • Pros and Cons of Rivfloza vs. Oxlumo

    Pros and Const for siRNA
    Pros
    •Can give at home after you get trained on how to inject the medication yourself
    •Only need to take once per month
    •Available in a prefilled syringe for convenience
    Cons
    •Injections can be uncomfortable
    •Doesn't cure PH1; only helps to control symptoms
    •Not approved for children younger than 9 years old
    Pros and Const for Small interfering ribonucleic acid (siRNA)
    Pros
    •Works well to lower oxalate levels in people with PH1
    •Given every 1 or 3 months
    •Not a lot of side effects
    •Can use for adults and children of all ages
    Cons
    •Needs to be given by a healthcare provider
    •Injections might be uncomfortable.
    •Likely need to take for the rest of your life since PH1 is a genetic problem
    •No lower-cost generic available

  • Common Side Effects of Rivfloza vs. Oxlumo

    Common Side Effects for
    •Injection site reaction (e.g., redness, pain, bruising, rash; 39%)
    Common Side Effects for
    •Injection site reactions (redness, pain, itching, swelling; 38%)
    •Stomach pain (15%)

  • Warnings of Rivfloza vs. Oxlumo

    Common Side Effects for
    Common Side Effects for

  • Prices with our coupons for Rivfloza vs. Oxlumo

    Learn more about Rivfloza
    Learn more about Oxlumo

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.