Rivfloza vs. Oxlumo for Inherited Metabolic Diseases: Important Differences and Potential Risks.

Rivfloza

(nedosiran)

Oxlumo

(lumasiran)

Summary for Rivfloza

Prescription only

Rivfloza (nedosiran) is an injectable medication that's used to lower oxalate levels in the urine in people 9 years and older with a rare inherited, genetic condition called primary hyperoxaluria type 1 (PH1). This medication belongs to the drug class called small interfering RNA (siRNA). It works to stop the liver from making oxalate. Rivfloza (nedosiran) is injected under the skin once a month. The most common side effect is having an injection site reaction. Rivfloza (nedosiran) is a brand-name medication; it isn't available as a lower-cost generic.

Indications for Rivfloza

To lower oxalate levels in the urine in people 9 years and older with primary hyperoxaluria type 1 (PH1)

Pros and Cons for Rivfloza

Pros

Can give at home after you get trained on how to inject the medication yourself
Only need to take once per month
Available in a prefilled syringe for convenience

Cons

Injections can be uncomfortable
Doesn't cure PH1; only helps to control symptoms
Not approved for children younger than 9 years old

Common Side Effects for Rivfloza

Injection site reaction (e.g., redness, pain, bruising, rash; 39%)

Summary for Oxlumo

Prescription only

Oxlumo (lumasiran) is an injectable medication used to treat a rare condition called primary hyperoxaluria type 1 (PH1). This condition mainly affects the kidneys, but can also harm other organs. Oxlumo (lumasiran) doesn't have many side effects and is given every 1 or 3 months, depending on your weight.

Indications for Oxlumo

Lower the oxalate levels in people with primary hyperoxaluria type 1 (PH1)

Pros and Cons for Oxlumo

Pros

Works well to lower oxalate levels in people with PH1
Given every 1 or 3 months
Not a lot of side effects
Can use for adults and children of all ages

Cons

Needs to be given by a healthcare provider
Injections might be uncomfortable.
Likely need to take for the rest of your life since PH1 is a genetic problem
No lower-cost generic available

Common Side Effects for Oxlumo

Injection site reactions (redness, pain, itching, swelling; 38%)
Stomach pain (15%)

Prices with our coupons for Rivfloza vs. Oxlumo

Rivfloza1 carton / 1ml prefilled syringe of 160mg/ml

$65,289.29-

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Oxlumo1 vial / 94.5mg/0.5ml

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Rivfloza vs. Oxlumo

Rivfloza

Oxlumo

Summary for Rivfloza

Indications for Rivfloza

Pros and Cons for Rivfloza

Pros

Cons

Common Side Effects for Rivfloza

Summary for Oxlumo

Indications for Oxlumo

Pros and Cons for Oxlumo

Pros

Cons

Common Side Effects for Oxlumo

Prices with our coupons for Rivfloza vs. Oxlumo

Browse medications by letter

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Rivfloza

Oxlumo

Summary for Rivfloza

Indications for Rivfloza

Pros and Cons for Rivfloza

Pros

Cons

Common Side Effects for Rivfloza

Summary for Oxlumo

Indications for Oxlumo

Pros and Cons for Oxlumo

Pros

Cons

Common Side Effects for Oxlumo