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Progestin Antagonists

Progestin antagonists are used to treat Cushing's syndrome. They work by blocking cortisol which causes symptoms of Cushing's syndrome.

Why are progestin antagonists prescribed?

  1. Cushing's Syndrome (50%)
  2. Birth Control (50%)

Key takeaways

Progestin antagonists block the actions of progesterone in the body. They're used to manage high blood glucose levels in people living with Cushing's syndrome. They can also be used along with misoprostol to terminate an early pregnancy. Mifepristone (Korlym, Mifeprex) is the most common example of this class.

Prices for popular Progestin Antagonists medications
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Korlym (mifepristone)

MIFEPRISTONE treats high blood sugar (glucose) in people with Cushing Syndrome, a condition that occurs when the body releases too much of the hormone cortisol. Cortisol helps your body respond to stress in many ways, including by telling your body to release more sugar into the body for energy. This medication works by reducing the effects of cortisol in your body, which decreases your blood sugar.
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Mifeprex (mifepristone)

Mifepristone (Mifeprex) is an expensive drug used in combination with misoprostol for medical abortions. It is more popular than comparable drugs. It is available in generic and brand versions.
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Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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