Avandaryl is part of the Glitazone / Sulfonylurea Combinations class and treats Diabetes Type 2. Glitazone / sulfonylurea combinations are used to treat diabetes type 2. Glitazone lowers blood sugar by making the body more sensitive to insulin and by decreasing the amount of glucose made by the liver. Sulfonylurea works by increasing insulin production in the pancreas. Avandaryl is only available as a brand name drug.