Atypical antidepressants are used to treat depression, anxiety, and aid in smoking cessation. They work by increasing dopamine and norepinephrine in the brain to elevate mood and decrease nicotine cravings.

Why are
Atypical Antidepressants
prescribed?

How is this chart calculated?

How we make this chart

This chart is created by aggregating the total number of claims for the drugs in this class divided by the # of drugs with a specific indication. It is meant to be representative but may not accurately reflect the actual # of prescriptions written to treat a specific condition.

Prices for Popular Atypical Antidepressants

Popularity Brand Name (Generic Name) GoodRx Fair Price Price Trend
trazodone
7
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Trazodone (Desyrel, Trialodine) is an inexpensive drug used to treat depression. This drug is more popular than comparable drugs. It is available in multiple generic and brand versions. Generic trazodone is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Wellbutrin XL
(bupropion xl)
19
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Bupropion (bupropion XL, Wellbutrin XL, budeprion XL) is a moderately priced drug used to treat depression. This drug is slightly more popular than comparable drugs. It is available in multiple brand and generic forms. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Wellbutrin SR
(bupropion sr, budeprion sr)
17
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BUPROPION is used to treat depression.
Remeron
(mirtazapine)
10
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MIRTAZAPINE is used to treat depression.
Wellbutrin
(bupropion)
24
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BUPROPION is used to treat depression.
Trintellix
329
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Trintellix (vortioxetine) is used to treat depression. Trintellix is less popular than other atypical antidepressants. There are currently no generic alternatives to Trintellix. Brand-name drugs are expensive, but manufacturer and pharmacy coupons can help offset the cost. Trintellix is covered by some Medicare and insurance plans.
Zyban
(bupropion (Zyban), buproban)
36
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Zyban (bupropion extended-release) is an atypical antidepressant used as an aid in smoking cessation. Bupropion is also the active ingredient in Wellbutrin, which is used to treat depression. Both Zyban and Wellbutrin are available as generic bupropion, but may not be substituted for each other.
nefazodone
68
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NEFAZODONE is used to treat depression.
Forfivo XL
397
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BUPROPION is used to treat depression.
Aplenzin
1,204
See Prices
BUPROPION is used to treat depression.
Oleptro
107
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TRAZODONE is used to treat depression.

Note: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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