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MESALAMINE treats ulcerative colitis. It may also be used to prevent flare-ups once your symptoms are controlled. It works by decreasing inflammation in the digestive tract. It belongs to a group of medications called salicylates. Get Mesalamine ER for as low as $47.96, which is 90% off the average retail price of $457.31 for the most common version, by using a GoodRx coupon.