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Apretude

Apretude Side Effects

Kristianne Hannemann, PharmDDaisy Chau, PharmD
Reviewed by Kristianne Hannemann, PharmD, Daisy Chau, PharmD
Last reviewed on June 4, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Injection site reaction (38-82%)
  • Headache (4-12%)
  • Diarrhea (4%)
  • Nausea (3-4%)
  • Dizziness (2-4%)
  • Fever (up to 4%)
  • Upper respiratory tract infection (up to 4%)

Less Common Side Effects

  • Feeling tired
  • Trouble sleeping
  • Abnormal dreams
  • Stomach pain
  • Vomiting
  • Muscle pain
  • Rash
  • Lower appetite
  • Drowsiness

Apretude serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious allergic reactions: rash, mouth sores, feeling ill, trouble breathing, tiredness, fever, muscle or joint pain, swelling in the face, redness or swelling in the eyes
  • Liver problems: upper right stomach pain, yellowing of the skin or eyes, dark urine, light-colored stools nausea, vomiting, reduced appetite, itching
  • Mood changes: feeling sad, restlessness, anxiety, suicidal thoughts and behavior

Source: DailyMed

The following Apretude side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Thoughts of suicide or self-harm, worsening mood, feelings of depression

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

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