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Isentress

Isentress Side Effects

Allison Gourley, PharmDCydnee Ng, PharmD
Reviewed by Allison Gourley, PharmD, Cydnee Ng, PharmD
Last reviewed on September 26, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache (4%)
  • Trouble sleeping (4%)
  • Nausea (3%)

Less Common Side Effects

Note: Side effects were reported by adults new to HIV treatment who were taking [[EDITOR|DRUG_DISPLAY_NAME]] film-coated tablets.

Isentress serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe muscle damage: severe muscle pain, weakness, brownish-red urine
  • Severe skin reaction or severe allergic reaction: rash, hives, peeling skin, blisters, mouth sores, feeling unwell, muscle or joint aches, swelling of the face or lips, swelling around the eyes, difficulty breathing

Source: DailyMed

The following Isentress side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common or rare

Blood in the urine

burning or stinging of the skin

dark urine

decreased frequency or amount of urine

fast heartbeat

fever

hoarseness

increased thirst

irritation

joint pain, stiffness, or swelling

light-colored stools

loss of appetite

lower back or side pain

nausea

pain in the groin or genitals

painful blisters on the trunk of the body

painful cold sores or blisters on the lips, nose, eyes, or genitals

rash, hives, or itching

redness of the skin

sharp back pain just below the ribs

swelling of the eyelids, face, lips, hands, lower legs, or feet

tightness in the chest

trouble breathing or swallowing

unusual tiredness or weakness

upper right stomach pain

vomiting

weight gain

yellow eyes and skin

Incidence not known

Black, tarry stools

bleeding gums

headache

muscle cramps, spasms, pain, or stiffness

pinpoint red spots on the skin

stomach pain, continuing

unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Dizziness

trouble sleeping

Less common or rare

Belching

depression

heartburn

indigestion

lack or loss of strength

stomach discomfort, upset, or tenderness

thoughts of killing oneself or changes in behavior

Incidence not known

Delusions of persecution, mistrust, suspiciousness, or combativeness

diarrhea

fear or nervousness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.
Cydnee Ng, PharmD
Reviewed by:
Cydnee Ng, PharmD
Cydnee Ng, PharmD, is a drug information pharmacist at GoodRx, where she lends her expertise to providing reader-friendly, accessible content about medications. She holds her pharmacist license in California.

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