Is there an Ozempic pill?

No, Ozempic itself isn’t available as a pill. Ozempic is a brand-name injectable Type 2 diabetes medication that contains semaglutide. But there are oral (pill) versions of semaglutide, the same active ingredient in Ozempic. For several years, Rybelsus, which is also used for Type 2 diabetes, was the only oral semaglutide product available. As of January 2026, there’s now also an oral Wegovy pill, FDA approved specifically for weight loss.

The main difference between oral semaglutide pills and injections is how and when you take them. Injections like Ozempic and the Wegovy pen are administered once weekly and don’t have strict timing requirements around food, drinks, or other medications. Oral semaglutide pills like Rybelsus and the Wegovy pill are taken once daily, first thing in the morning on an empty stomach, with no more than 4 oz of plain water. You’ll need to wait at least 30 minutes before eating, drinking other liquids, or taking other medications.

In addition to the Wegovy pill, other oral weight-loss pill options include Qsymia (phentermine / topiramate ER), Contrave (naltrexone / bupropion), and Xenical or Alli (orlistat). While these medications haven’t been compared directly, the Wegovy pill may lead to greater weight loss than other oral options. Another oral medication that works like Wegovy is orforglipron, which may be approved in 2026.