Is there an Ozempic pill?

Yes, there is now an Ozempic pill, but it’s different from the original product. Ozempic was initially only available as a once-weekly injection containing semaglutide, which is still on the market. For years, Rybelsus was the only oral semaglutide product approved for Type 2 diabetes (the R1 formulation). As of 2026, the reformulated version of Rybelsus (called R2) is sold under the Ozempic brand name. There’s now also an oral Wegovy pill, FDA approved for weight loss.

The main difference between oral semaglutide pills and injections is how and when you take them. Injections like the Ozempic pen and Wegovy pen are administered once weekly and don’t have strict timing requirements around food, drinks, or other medications. Oral semaglutide pills like Rybelsus, the Ozempic pill, and the Wegovy pill are taken once daily, first thing in the morning on an empty stomach, with no more than 4 oz of plain water. You’ll need to wait at least 30 minutes before eating, drinking other liquids, or taking other medications.

In addition to the Wegovy pill, other common oral weight-loss pill options include Qsymia (phentermine / topiramate ER), Contrave (naltrexone / bupropion), and Xenical or Alli (orlistat). While these medications haven’t been compared directly, the Wegovy pill may lead to greater weight loss than other oral options. Another oral medication that works like Wegovy is orforglipron, which may be approved in 2026.