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Amitiza (lubiprostone) is a laxative used to treat chronic constipation and constipation caused by opioids. Amitiza is the only drug in the chloride channel activators class. There are currently no generic alternatives to Amitiza.
Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost. Amitiza is covered by most Medicare and insurance plans.
Get Lubiprostone for as low as $33.44, which is 90% off the average retail price of $328.03 for the most common version, by using a GoodRx coupon.

| Dosage | Quantity | Retail price | GoodRx price |
|---|
| 8mcg | 60 capsules | $309.40 | $41.39 |
| 24mcg | 60 capsules | $309.38 | $43.44 |









200+ medications are free, with hundreds more under $10. Just $14.99/mo. Terms apply.
GoodRx coupon prices last updated on 05/15/26.
*Prices subject to change without notice. Sales tax may apply and is not included.