The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Drowsiness
- Sleepiness
- Lightheadedness
- Dizziness
- Trouble breathing
- Nausea
- Vomiting
- Constipation
- Sweating
Less Common Side Effects
- Changes in mood
- Stomach pain
- Rash
- Itchy skin
Acetaminophen/Codeine serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Opioid overdose: not responding to sound or touch, very slow breathing, extreme sleepiness, slow heartbeat, pinpoint pupils, cold or clammy skin
- Dangerously slow breathing: trouble breathing, blue or gray lips, fingers, or toes, can't wake up
- Liver damage: pain in the upper right side of your stomach, dark urine, yellow skin or eyes
- Severe allergic reaction: hives, swelling of your face, lips, or tongue, trouble breathing
- Serious skin reaction: rash, blisters, skin redness, skin peeling
Source: DailyMed
More on Acetaminophen/Codeine side effects

The following Acetaminophen/Codeine side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Difficult or trouble breathing
irregular, fast or slow, or shallow breathing
pale or blue lips, fingernails, or skin
Incidence not known
Black, tarry stools
bleeding gums
blood in the urine or stools
difficulty with swallowing
dizziness
fast heartbeat
fever with or without chills
general feeling of tiredness or weakness
hoarseness
lower back or side pain
painful or difficult urination
pinpoint red spots on the skin
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
sores, ulcers, or white spots on the lips or in the mouth
tightness in the chest
unusual bleeding or bruising
unusual tiredness or weakness
Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
Bloody or cloudy urine
chills
constricted, pinpoint, or small pupils (black part of the eye)
dark urine
headache
increased sweating
light-colored stools
loss of appetite
loss of consciousness
seizures
stomach pain
sudden decrease in the amount of urine
unpleasant breath odor
vomiting
vomiting of blood
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Drowsiness
lightheadedness
relaxed and calm feeling
sleepiness
Incidence not known
Difficulty having a bowel movement
false or unusual sense of well-being
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.



