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Acetaminophen/Codeine

Acetaminophen/Codeine Side Effects

Robert Chad Hakim, PharmD, BCCCPCydnee Ng, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Cydnee Ng, PharmD
Last reviewed on August 24, 2026

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Drowsiness
  • Sleepiness
  • Lightheadedness
  • Dizziness
  • Trouble breathing
  • Nausea
  • Vomiting
  • Constipation
  • Sweating

Less Common Side Effects

  • Changes in mood
  • Stomach pain
  • Rash
  • Itchy skin

Acetaminophen/Codeine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Opioid overdose: not responding to sound or touch, very slow breathing, extreme sleepiness, slow heartbeat, pinpoint pupils, cold or clammy skin
  • Dangerously slow breathing: trouble breathing, blue or gray lips, fingers, or toes, can't wake up
  • Liver damage: pain in the upper right side of your stomach, dark urine, yellow skin or eyes
  • Severe allergic reaction: hives, swelling of your face, lips, or tongue, trouble breathing
  • Serious skin reaction: rash, blisters, skin redness, skin peeling
When do Acetaminophen/Codeine possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Drowsiness
Nausea or vomiting
Constipation
Trouble breathing
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

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The following Acetaminophen/Codeine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Difficult or trouble breathing

irregular, fast or slow, or shallow breathing

pale or blue lips, fingernails, or skin

Incidence not known

Black, tarry stools

bleeding gums

blood in the urine or stools

cough

difficulty with swallowing

dizziness

fast heartbeat

fever with or without chills

general feeling of tiredness or weakness

hives, itching, skin rash

hoarseness

lower back or side pain

painful or difficult urination

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

sore throat

sores, ulcers, or white spots on the lips or in the mouth

tightness in the chest

unusual bleeding or bruising

unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Bloody or cloudy urine

chills

constricted, pinpoint, or small pupils (black part of the eye)

dark urine

headache

increased sweating

light-colored stools

loss of appetite

loss of consciousness

nausea

seizures

stomach pain

sudden decrease in the amount of urine

unpleasant breath odor

vomiting

vomiting of blood

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Drowsiness

lightheadedness

relaxed and calm feeling

sleepiness

Incidence not known

Difficulty having a bowel movement

false or unusual sense of well-being

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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