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Vicodin

hydrocodone / acetaminophen
Used for Pain
Used for Pain

Vicodin is a combination medication that contains hydrocodone (an opioid) and acetaminophen (an analgesic). It's used to manage pain for people who haven't gotten enough relief from non-opioid medications. Vicodin (hydrocodone / acetaminophen) is a pill that's taken by mouth. Common side effects include nausea and sleepiness.

Please note: The brand name Vicodin is no longer available in the United States. Talk to your prescriber about alternative options to manage your pain.

Last reviewed on April 8, 2024
Vicodin (hydrocodone / acetaminophen) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Vicodin (hydrocodone / acetaminophen)?

What is Vicodin (hydrocodone / acetaminophen) used for?

  • Pain that isn't relieved by non-opioid pain medications alone

How Vicodin (hydrocodone / acetaminophen) works

Vicodin (hydrocodone / acetaminophen) is a combination of two medications that work together to treat pain.

  • Hydrocodone is an opioid. It attaches to certain mu-opioid receptors in your brain to lower how much pain you feel.

  • Acetaminophen is an analgesic. It blocks the production of certain chemicals in your brain that play a role in pain. As a result, acetaminophen helps relieve pain.

Drug Facts

Common BrandsVicodin, Vicodin ES, Vicodin HP (brand names no longer available)
Drug ClassOpioid / Analgesic
Controlled Substance ClassificationSchedule II
Generic StatusLower-cost generic available
AvailabilityDiscontinued

More on Vicodin (hydrocodone / acetaminophen) essentials

warings-icon

What are the risks and warnings for Vicodin (hydrocodone / acetaminophen)?

Vicodin (hydrocodone / acetaminophen) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

Potential for misuse and addiction

  • Risk factors: Personal or family history of alcohol or substance use disorder | Personal or family history of mental health conditions

    Vicodin (hydrocodone / acetaminophen) is a controlled substance because there's a risk for misuse and addiction. Take the medication exactly as prescribed. Don't change the dose or how often you take it without talking to your prescriber first.

    Misusing Vicodin (hydrocodone / acetaminophen) might cause the medication to work less well. It can also raise the risk for serious and possibly life-threatening side effects, such as dangerously slow breathing, inability to stay awake, addiction, and opioid overdose. You'll be prescribed the lowest amount of Vicodin (hydrocodone / acetaminophen) that can help manage your pain for the shortest period of time possible.

    Because of the risk for misuse, addiction, and overdose, Vicodin (hydrocodone / acetaminophen) is only available through a Risk Evaluation and Mitigation Strategy (REMS) program called the Opioid Analgesic REMS program. Your prescriber and pharmacy must register with the program, receive training on proper medication use, and talk with you about how to safely use Vicodin (hydrocodone / acetaminophen).

    risk-warning

    Dangerously slow breathing (respiratory depression)

    • Risk factors: Taking medications that can cause slow breathing | Drinking alcohol | Older age | Being frail | Medical conditions that cause breathing problems (e.g., COPD, asthma, head injury) | Taking too much Vicodin (hydrocodone / acetaminophen)

      Opioids like Vicodin (hydrocodone / acetaminophen) can cause dangerously slow breathing, which can be life-threatening. This can happen to anyone and at recommended doses. But the risk is greatest when you first start treatment or when your dose goes up.

      Don't drink alcohol while you're taking an opioid medication. And don't take opioids at the same time as other medications that slow your body down (e.g., benzodiazepines, other opioids, muscle relaxants). Doing so raises your risk of extremely slowed breathing.

      Your prescriber might write a prescription for naloxone (Narcan), a medication that helps reverse slowed breathing from opioids. Keep it with you at all times. Use naloxone, call 911, and get medical help right away if you or your loved one notices that you have trouble breathing or have bluish-colored lips, fingers, or toes.

      risk-warning

      Opioid overdose

      • Risk factors: History of opioid use disorder | Previous opioid overdose | Taking high doses of Vicodin (hydrocodone / acetaminophen) | Taking more opioids than prescribed | Alcohol use

        Take opioid medications like Vicodin (hydrocodone / acetaminophen) exactly as prescribed. Taking too much or taking them more often than prescribed can lead to an overdose. In addition, it can be very dangerous if someone accidentally swallows the medication. Place the opioid medication out of reach from children, pets, or visitors to prevent accidental overdose.

        Symptoms of an opioid overdose include not responding to sound or touch, extremely slowed breathing, extreme sleepiness, slow heartbeat, and cold or clammy skin. Be sure you and your loved ones know how to recognize an overdose. Your prescriber will probably write a prescription for naloxone (Narcan), a medication that can treat an opioid overdose. Have naloxone with you at all times; use it and call 911 right away if an overdose happens.

        risk-warning

        Difficulty concentrating and extreme sleepiness

        • Risk factors: Taking high doses of Vicodin (hydrocodone / acetaminophen) | Age 65 years or older | Drinking alcohol | Taking other medications that can cause sleepiness

          Opioids like Vicodin (hydrocodone / acetaminophen) can cause extreme sleepiness. They can also lower your ability to think, react, and focus. Don't drink alcohol or take other medications that can cause sleepiness or "brain fog" (e.g., benzodiazepines, muscle relaxants, sleep medications) with Vicodin (hydrocodone / acetaminophen). Doing so can worsen these side effects.

          Make sure you know how opioid medications affect you before driving a car or doing activities that require your concentration. Talk to a healthcare professional (HCP) if you feel too sleepy after taking an opioid medication.

          risk-warning

          Liver damage

          • Risk factors: Drinking alcohol | Taking other medications containing acetaminophen | Taking too much Vicodin (hydrocodone / acetaminophen) | History of liver problems

            Vicodin (hydrocodone / acetaminophen) contains acetaminophen. Taking too much acetaminophen can cause liver damage that can be life-threatening. The risk for liver damage is higher if you're taking more than one medication that contains acetaminophen, if you already have liver problems, or if you regularly drink alcohol.

            Let your prescriber know about your medical history, especially if you have liver problems, before you take Vicodin (hydrocodone / acetaminophen). Also avoid drinking alcohol while you're taking this medication. Your prescriber can discuss how much acetaminophen you can take per day depending on your age and your risk for liver damage.

            Call an HCP right away if you notice any symptoms of liver damage. These symptoms can include tiredness, dark urine, upset stomach, stomach pain, or yellowing of the skin or whites of the eyes.

            risk-warning

            Drug interactions

            Vicodin (hydrocodone / acetaminophen) interacts with a lot of common medications. So it's important to tell your prescriber and pharmacist about the medications you're taking and planning to take with Vicodin (hydrocodone / acetaminophen). Your care team can check that your medications are safe to take together. Also talk to your care team before making any changes to your medications because sudden adjustments can also lead to harm.

            Some interactions can raise the level of Vicodin (hydrocodone / acetaminophen) in your body. This can raise your risk for serious side effects, including potentially life-threatening slowed breathing. Examples of medications that interact this way with Vicodin (hydrocodone / acetaminophen) include erythromycin, ketoconazole, and ritonavir (Norvir).

            Other drug interactions can lower the levels of Vicodin (hydrocodone / acetaminophen) in your body. This can cause the opioid medication to work less well for pain and possibly lead to withdrawal symptoms. These interactions include taking Vicodin (hydrocodone / acetaminophen) with rifampin (Rifadin) or carbamazepine (Tegretol).

            risk-warning

            Harm to newborn babies

            Long-term use of Vicodin (hydrocodone / acetaminophen) during pregnancy can cause your unborn baby to become dependent on the medication. This is because the opioid (hydrocodone) can pass through the placenta to your unborn baby.

            Once your baby is born, they can experience withdrawal symptoms, such as high-pitched crying, poor feeding behavior, abnormal sleep patterns, and seizures. These symptoms can be life-threatening if not recognized and treated in time. Let your HCP know if you've used Vicodin (hydrocodone / acetaminophen) or any other opioids during pregnancy or if you notice these symptoms in your baby.

            risk-warning

            Severe allergic reactions and skin reactions

            • Risk factors: Allergy to other opioids

              Severe allergic reactions to Vicodin (hydrocodone / acetaminophen) are possible, including life-threatening reactions like facial swelling, shock, and anaphylaxis (e.g., closing of the throat). Though rare, acetaminophen can also cause serious skin reactions, like rash, blisters, skin reddening, or skin peeling. Get medical help right away if you notice unusual changes in your skin, swelling of the lips or tongue, or difficulty breathing.

              risk-warning

              Physical dependence and withdrawal

              • Risk factors: Long-term use of Vicodin (hydrocodone / acetaminophen)

                Opioids like Vicodin (hydrocodone / acetaminophen) can cause physical dependence when they're taken for a long time. This means that your body starts to rely on the medication to function. You might experience withdrawal if you suddenly stop taking the medication or lower your dose too fast. Withdrawal symptoms can be bothersome and include anxiety, restlessness, irritability, sweating, and chills.

                Don't lower your dose or stop taking the medication suddenly without talking to your prescriber first. Your prescriber will slowly lower your dose to prevent withdrawal symptoms. Talk to your prescriber about alternative pain medications if you have concerns about the risk for dependence and withdrawal with opioid use.

                risk-warning

                Low blood pressure

                Vicodin (hydrocodone / acetaminophen) and other opioids can cause extremely low blood pressure. Your blood pressure might drop when you stand from a sitting or lying down position. This can lead to dizziness and fainting. To avoid falling, get up slowly if you've been sitting or lying down. Talk to your HCP if any dizziness or lightheadedness doesn't go away.

                risk-warning

                Low adrenal hormone levels

                • Risk factors: Taking Vicodin (hydrocodone / acetaminophen) for longer than 1 month

                  Some people who take opioid medications like Vicodin (hydrocodone / acetaminophen) have had low adrenal hormone levels. This might be more likely to happen after taking opioids for longer than 1 month. Symptoms include tiredness, dizziness, weakness, not feeling hungry, and nausea. Call an HCP if you have these symptoms. If your adrenal hormone levels are too low, you might need to stop Vicodin (hydrocodone / acetaminophen) and get treated with corticosteroids.

                  risk-warning

                  Seizures

                  • Risk factors: History of seizure conditions

                    Opioids such as hydrocodone can raise the risk of having seizures more often in people who've had one before. Opioid medications can also raise your risk of seizures in certain situations. Get medical help right away if you have a seizure while you're taking this medication.

                    basics-icon

                    What are the side effects of Vicodin (hydrocodone / acetaminophen)?

                    The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

                    Common Side Effects

                    • Lightheadedness
                    • Dizziness
                    • Sleepiness
                    • Nausea
                    • Vomiting

                    Other Side Effects

                    • Constipation
                    • Stomach pain
                    • Headache
                    • Tiredness
                    • "Brain fog"
                    • Itching
                    • Changes in blood pressure

                    Serious Side Effects

                    Contact your healthcare provider immediately if you experience any of the following.
                    • Dangerously slow breathing: trouble breathing; bluish-colored lips, fingers, or toes
                    • Accidentally taking too much (overdose): not responding to sound or touch, slowed breathing, extreme sleepiness, cold or clammy skin, slow heartbeat, upper right-sided stomach pain, dark urine, yellowing of your skin or eyes
                    • Opioid withdrawal: anxiety, suicidal thoughts, restlessness, runny nose, yawning, sweating, chills, wide pupils, irritability
                    • Serious allergic reaction or skin reaction: rash, hives, blistering or peeling skin, shortness of breath, fast heartbeat, dizziness, feeling warm suddenly

                    Source: DailyMed

                    The following side effects have also been reported

                    Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

                    Check with your doctor immediately if any of the following side effects occur:

                    More common

                    Dizziness

                    lightheadedness

                    Incidence not known

                    Back, leg, or stomach pains

                    black, tarry stools

                    bleeding gums

                    blood in the urine or stools

                    blood in vomit

                    bluish lips or skin

                    chills

                    choking

                    cough

                    dark urine

                    decrease in the frequency of urination

                    decrease in urine volume

                    difficult or trouble breathing

                    difficulty in passing urine (dribbling)

                    difficulty with swallowing

                    fast heartbeat

                    fever

                    fever with or without chills

                    general body swelling

                    general feeling of tiredness or weakness

                    headache

                    hoarseness

                    irregular, fast or slow, or shallow breathing

                    light-colored stools

                    loss of appetite

                    lower back or side pain

                    nausea

                    nosebleeds

                    not breathing

                    painful or difficult urination

                    pale or blue lips, fingernails, or skin

                    pinpoint red spots on the skin

                    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

                    severe or continuing stomach pain

                    skin rash, hives, or itching

                    sore throat

                    sore tongue

                    sores, ulcers, or white spots on the lips or in the mouth

                    tightness in the chest

                    unable to speak

                    unusual bleeding or bruising

                    unusual tiredness or weakness

                    upper right abdominal or stomach pain

                    vomiting

                    yellow eyes and skin

                    Get emergency help immediately if any of the following symptoms of overdose occur:

                    Symptoms of overdose

                    Bloody or cloudy urine

                    change in consciousness

                    chest pain or discomfort

                    cold and clammy skin

                    decreased awareness or responsiveness

                    extreme drowsiness

                    general feeling of discomfort or illness

                    increased sweating

                    irregular heartbeat

                    lightheadedness, dizziness, or fainting

                    loss of consciousness

                    no blood pressure or pulse

                    no muscle tone or movement

                    not breathing

                    severe sleepiness

                    slow or irregular heartbeat

                    stopping of heart

                    sudden decrease in the amount of urine

                    unpleasant breath odor

                    Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

                    More common

                    Drowsiness

                    relaxed and calm feeling

                    sleepiness

                    Incidence not known

                    Belching

                    changes in mood

                    difficulty having a bowel movement

                    fear or nervousness

                    feeling of indigestion

                    hearing loss

                    impaired hearing

                    pain in the chest below the breastbone

                    unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

                    Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

                    Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

                    pros-and-cons

                    Pros and cons of Vicodin (hydrocodone / acetaminophen)

                    thumbs-up

                    Pros

                    Takes about 30 minutes start relieving pain

                    Combines two pain medications within a single product

                    thumbs-down

                    Cons

                    Has a risk of misuse and dependence

                    Not recommended to take with other medications containing acetaminophen since it can raise the risk of liver damage

                    pharmacist-tips

                    Pharmacist tips for Vicodin (hydrocodone / acetaminophen)

                    pharmacist
                    • Constipation is a common side effect when you take opioid medications like Vicodin (hydrocodone / acetaminophen). Stay hydrated and add more fiber to your diet. Speak with your care team if these tips aren't enough to help with constipation. Your prescriber can recommend medications or a change in your pain treatment.

                      • Opioid medications can make you sleepy or dizzy. They can also lower how clearly you can think or how fast you can react. Don't drive or do activities that need your attention until you know how opioid medications like Vicodin (hydrocodone / acetaminophen) affect you.

                        • Don't drink alcohol while you're taking opioids like Vicodin (hydrocodone / acetaminophen). Alcohol can worsen sleepiness and dizziness and make it hard for you to think clearly. Taking Vicodin (hydrocodone / acetaminophen) with alcohol can also harm your liver.

                          • Take opioids like Vicodin (hydrocodone / acetaminophen) exactly as prescribed. Don't change your dose or stop taking the medication without talking to your prescriber. Your prescriber might lower your dose slowly over time before you can completely stop the medication. This helps prevent bothersome withdrawal symptoms like muscle aches, chills, and trouble sleeping.

                            • Your prescriber will discuss about having naloxone (Narcan) with you at all times. Naloxone is a medication that can help reverse the effects of opioid medications in situations like very slowed breathing or an accidental overdose. Teach your loved ones about how to give naloxone to you if you can't do it yourself. Call 911 right away if you need to use naloxone because this is a medical emergency.

                              • Place opioid medications like Vicodin (hydrocodone / acetaminophen) out of reach from children, pets, and visitors. Find a drug take-back location to safely get rid of the medication if you don't need it anymore. This helps lessen the risk for accidental overdose and medication misuse.

                                faqs

                                Frequently asked questions about Vicodin (hydrocodone / acetaminophen)

                                Is Vicodin (hydrocodone / acetaminophen) an opioid?
                                Yes. Vicodin (hydrocodone / acetaminophen) is a combination medication that has an opioid called hydrocodone in it. The other ingredient is acetaminophen, also known as Tylenol.
                                Does Vicodin (hydrocodone / acetaminophen) have a risk for addiction?
                                Yes, opioid medications like Vicodin (hydrocodone / acetaminophen) have a risk for addiction. It's one of the reasons why opioids are considered controlled substances. Addiction can happen as a result of misuse, or when a medication is used for non-medical reasons for its desirable physical or emotional effects. Signs of addiction include having cravings to use the medication, continuing to use the medication even though you have negative consequences from it, and having withdrawal symptoms when you stop taking it. Take opioid medications exactly as prescribed to you. Don't change the dose or how often you take it without talking to your prescriber. Talk with your prescriber if you're concerned about the risk for addiction.
                                Does Vicodin (hydrocodone / acetaminophen) make you sleepy?
                                Yes, opioids like Vicodin (hydrocodone / acetaminophen) can make you sleepy. Let your prescriber and care team know if you're taking other medications that make you sleepy, such as benzodiazepines or muscle relaxants. Mixing opioids with these types of medications or alcohol can make sleepiness more intense. Avoid alcohol while you're taking opioids. Also avoid driving or doing anything that requires concentration until you know how Vicodin (hydrocodone / acetaminophen) affects you.
                                How long does it take for Vicodin (hydrocodone / acetaminophen) to kick in?
                                It takes about 30 minutes for Vicodin (hydrocodone / acetaminophen) to start working to relieve pain.
                                What's the difference between Vicodin (hydrocodone / acetaminophen) and Percocet (oxycodone / acetaminophen)?
                                Vicodin (hydrocodone / acetaminophen) and Percocet (oxycodone / acetaminophen) are both pain medications that contain a combination of an opioid and acetaminophen. But the opioid is different: Vicodin contains hydrocodone, and Percocet contains oxycodone. Some studies comparing these opioids showed that they generally work just as well as each other for pain. Nausea and dizziness occurred less often in people who took acetaminophen with hydrocodone than with oxycodone. But another study found that constipation from hydrocodone was more common than from oxycodone. Speak with your prescriber to learn more about the differences between Vicodin and Percocet.
                                What's the difference between Norco and Vicodin?
                                Norco and Vicodin are brand-name medications that contain the same two active ingredients, hydrocodone and acetaminophen. Both brand-name medications have strengths that contain 5 mg, 7.5 mg, or 10 mg of hydrocodone. But Vicodin and Norco contain differing amounts of acetaminophen. Both Vicodin and Norco brand names have been discontinued and aren't available in the United States anymore. But there are generic hydrocodone/acetaminophen tablets that are still available.
                                Can I take Vicodin (hydrocodone / acetaminophen) if I'm pregnant?
                                Opioids like Vicodin (hydrocodone / acetaminophen) generally aren't recommended during pregnancy unless the benefits are clearly greater than the risks. Taking opioids while you're expecting can raise the risk of developmental and growth problems in your baby. Your unborn baby can become dependent on the opioid and then develop neonatal opioid withdrawal syndrome after they're born. This is a serious, life-threatening problem that happens when your newborn baby has opioid withdrawal symptoms, like poor feeding and sucking behavior, abnormal sleep patterns, and possibly seizures. Your baby will need immediate medical care if this happens. Discuss with your prescriber about the risks and benefits of Vicodin (hydrocodone / acetaminophen) if you're pregnant or thinking of becoming pregnant. There might be safer options for you.
                                Can I take Vicodin (hydrocodone / acetaminophen) if I'm breastfeeding?
                                Discuss with your prescriber about the risks and benefits of taking Vicodin (hydrocodone / acetaminophen) while you're breastfeeding. If you need to breastfeed, it's usually recommended to try non-opioid pain medications first before considering opioid medications. This is because the hydrocodone in this combination medication can get into breast milk. Breastfeeding your baby while you're taking this opioid medication can raise the risk of serious and potentially life-threatening side effects in your baby. These side effects can include sleepiness, slowed breathing or other breathing problems, slowed heartbeat, and limpness. Speak with your prescriber about other options that might be safer, like switching to another medication or using baby formula instead.
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                                dosage

                                Vicodin (hydrocodone / acetaminophen) dosage forms

                                Typical dosing for Vicodin (hydrocodone / acetaminophen)

                                Your prescriber will work with you to find the right dose of Vicodin (hydrocodone / acetaminophen) for your individual needs. It's recommended to use the lowest dose possible for the shortest duration of time to manage your pain.

                                Vicodin (hydrocodone / acetaminophen) is typically taken by mouth every 4 to 6 hours as needed for pain.

                                interactions

                                Interactions between Vicodin (hydrocodone / acetaminophen) and other drugs

                                Vicodin (hydrocodone / acetaminophen) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Vicodin (hydrocodone / acetaminophen). Please note that only the generic name of each medication is listed below.

                                Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                                Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                drug-cost

                                How much does Vicodin (hydrocodone / acetaminophen) cost?

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                                contraindications-icon

                                Vicodin (hydrocodone / acetaminophen) contraindications

                                Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Vicodin (hydrocodone / acetaminophen) will not be safe for you to take.
                                • Severely slowed breathing (respiratory depression)

                                • Severe asthma

                                • Medical conditions that cause blockage of the stomach passageway

                                • Allergy to hydrocodone or acetaminophen

                                alternatives

                                What are alternatives to Vicodin (hydrocodone / acetaminophen)?

                                There are a number of medications that your doctor can prescribe in place of Vicodin (hydrocodone / acetaminophen). Compare a few possible alternatives below.
                                Vicodin (hydrocodone / acetaminophen)
                                Used for:
                                • Pain that isn't relieved by non-opioid pain medications alone

                                Used for:
                                $8.25 Lowest GoodRx priceView Prices
                                latest news

                                What is the latest news about Vicodin (hydrocodone / acetaminophen)?

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                                References

                                Best studies we found
                                View All References (14)

                                Chang, A. K., et al. (2015). Comparative analgesic efficacy of oxycodone/acetaminophen versus hydrocodone/acetaminophen for short-term pain management in adults following ED discharge. Academic Emergency Medicine.

                                Committee on Obstetric Practice Breastfeeding Expert Work Group. (2021). Breastfeeding challenges: ACOG Committee Opinion, number 820. Obstetrics & Gynecology.

                                Drugs and Lactation Database (LactMed®). (2023). Hydrocodone. National Institute of Child Health and Human Development.

                                Gerriets, V., et al. (2024). Acetaminophen. StatPearls.

                                Larson, J. J., et al. (2019). Cognitive and behavioral impact on children exposed to opioids during pregnancy. Pediatrics.

                                Marco, C. A., et al. (2005). Comparison of oxycodone and hydrocodone for the treatment of acute pain associated with fractures: A double-blind, randomized, controlled trial. Academic Emergency Medicine.

                                McCarberg, B. H. (2007). The treatment of breakthrough pain. Pain Medicine.

                                McNicol, E., et al. (2003). Management of opioid side effects in cancer-related and chronic noncancer pain: A systematic review. The Journal of Pain.

                                MedlinePlus. (2023). Prescription drug misuse.

                                National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Adrenal insufficiency & Addison’s disease.

                                National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Symptoms and causes of adrenal insufficiency & Addison’s disease.

                                U.S. Food and Drug Administration. (2016). FDA drug safety communication: FDA warns of rare but serious skin reactions with the pain reliever/fever reducer acetaminophen.

                                U.S. Food and Drug Administration. (2022). Drug disposal: Drug take back locations.

                                Weller, A. E., et al. (2021). Neonatal opioid withdrawal syndrome (NOWS): A transgenerational echo of the opioid crisis. Cold Spring Harbor Perspectives in Medicine.

                                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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