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Zidovudine

Zidovudine Side Effects

Hope Chang, PharmD, AAHIVPMichelle Nguyen, PharmD
Reviewed by Hope Chang, PharmD, AAHIVP, Michelle Nguyen, PharmD
Last reviewed on April 1, 2021

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache (63%)
  • Fatigue and discomfort (53%)
  • Nausea (51%)
  • Anorexia (20%)
  • Vomiting (17%)

Less Common Side Effects

  • Weakness/lack of energy
  • Constipation

Source: DailyMed

The following Zidovudine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Black, tarry stools

chills

cough

feeling of fullness

fever

lower back or side pain

painful or difficult urination

pale skin

right upper abdominal pain and fullness

sore throat

stomach pain

swelling or inflammation of the mouth

swollen lymph nodes

ulcers, sores, or white spots in the mouth

unusual bleeding or bruising

unusual tiredness or weakness

Rare

Confusion

diarrhea

fast, shallow breathing

general feeling of discomfort

loss of appetite

mood or mental changes

muscle pain, tenderness, weakness, or cramping

nausea

seizures

sleepiness

stomach discomfort

Incidence not known

Back or leg pain

bleeding gums

blistering, peeling, or loosening of the skin

bloating

blood in the urine

blurred vision or other change in vision

bone pain

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

clay-colored stools

constipation

dark urine

decreased appetite

decreased urine output

difficult or labored breathing

difficulty in moving

difficulty in swallowing

dilated neck veins

dizziness

extreme tiredness or weakness

fainting

fast, irregular, or pounding heartbeat

general body swelling

general tiredness and weakness

headache

high fever

hives, skin rash

hoarseness

increased need to urinate

indigestion

irregular breathing

irritation or soreness of the mouth

joint or muscle pain

lack of coordination

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals

light-colored stools

muscle pain, cramp, spasm, or stiffness

nosebleeds

pains in the stomach, side, or abdomen, possibly radiating to the back

passing urine more often

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

red skin lesions, often with a purple center

red, irritated eyes

redness, soreness, or itching skin

runny nose

shakiness in the legs, arms, hands, or feet

shivering

sores, welts, or blisters

stabbing pain

sweating

swollen joints

swollen or painful glands

tightness in the chest

trouble sleeping

unexplained bleeding or bruising

unpleasant breath odor

vomiting

vomiting of blood

weight gain

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Difficulty having a bowel movement

headache (severe)

lack or loss of strength

muscle soreness

weight loss

Less common

Bluish-brown colored bands on nails

changes in skin color

Incidence not known

Belching

heartburn

stomach cramps

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Hope Chang is a freelance writer and content reviewer for GoodRx. She attended Howard University College of Pharmacy in Washington, D.C. and completed post-graduate residency training at the University of California, Davis Medical Center.
Michelle Nguyen, PharmD, has been a clinical pharmacist for 6 years (and counting). She has a diverse skill set within managed care pharmacy, specifically in the settings of a medical group, pharmacy benefit manager (PBM), and health plan.

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