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Xiidra Coupon - Xiidra 60 ampules of 5% carton

Xiidra

lifitegrast
Used for Dry Eye
Used for Dry Eye

Xiidra (lifitegrast) is an eye drop medication that treats dry eye in adults. It belongs to a drug class called LFA-1 antagonists. It's thought help lower inflammation and other symptoms of dry eye. Usually, you need to use Xiidra (lifitegrast) every day. You put 1 drop into each eye twice a day. Side effects include temporary eye irritation and unclear vision. At this time, Xiidra (lifitegrast) is available only as a brand medication. There's no generic version yet.

Reviewed by:
reviewer
Cydnee Ng, PharmD
reviewer
Allison Gourley, PharmD
Last reviewed on May 27, 2025
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostAlternativesLatest newsImagesReferencesPricesMedicare
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What is Xiidra (lifitegrast)?

What is Xiidra (lifitegrast) used for?

How Xiidra (lifitegrast) works

Xiidra (lifitegrast) is a lymphocyte function-associated antigen-1 (LFA-1) antagonist. It blocks a protein called LFA-1.

LFA-1 normally causes an immune response in the eye. This can lead to inflammation (e.g., redness, swelling) and dry eye.

It's not exactly clear how Xiidra (lifitegrast) works to help with dry eye. But it's thought that by blocking LFA-1, it helps lower inflammation and ease dry eye symptoms.

When does Xiidra (lifitegrast) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsXiidra
Drug ClassLFA-1 antagonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Xiidra (lifitegrast) essentials

Health: Xiidra: GettyImages 997757818

Xiidra vs. Restasis: 6 Ways These Dry Eye Treatments Compare

Written by Christina Aungst, PharmD
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Avg retail price
$870.67(save 21.72%)
GoodRx discount
$681.60
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What are the side effects of Xiidra (lifitegrast)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Eye irritation (5-25%)
  • Strange taste in the mouth (5-25%)
  • Unclear vision (5-25%)

Other Side Effects

  • Blurred vision
  • Eye redness
  • Watery eye
  • Eye discharge
  • Eye discomfort
  • Itchy eye
  • Headache
  • Sinus infection
When do Xiidra (lifitegrast) possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Eye irritation
Strange taste in the mouth
Unclear vision

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Xiidra (lifitegrast)

thumbs-up

Pros

Works to help treat dry eye in the long run

Might be less likely to cause burning in the eyes than Restasis (cyclosporine)

thumbs-down

Cons

Won't give you instant relief and have to take for a couple weeks before it starts working

Not approved for people younger than 17 years old

pharmacist-tips

Pharmacist tips for Xiidra (lifitegrast)

pharmacist

  • Keep the single-use containers of Xiidra (lifitegrast) at room temperature. Don't take them out of the foil pouch until you're ready to use the medication. These pouches help protect the medication from light.

    • Wash your hands before each time you use Xiidra (lifitegrast). Also don't let the tip of the container touch your eye or any other surface. This helps you avoid getting germs in your eyes, which can prevent eye infections.

      • If you wear contact lenses, take them out before using Xiidra (lifitegrast). Then, wait at least 15 minutes afterwards to put them back in.

        • Use the eye drops right after you open the Xiidra (lifitegrast) container. Each container has enough medication for 1 drop in both eyes.

          • How to use Xiidra (lifitegrast) eye drops: Hold the container upright, and tap the top to move all the medication to the bottom. Twist off the tab to open it. Tilt your head backwards or lie down with your face up. Then, gently pull down your lower eyelid. While looking up, squeeze out 1 drop into the space between your lower eyelid and your eye. If you miss, you can try again. Do the same thing for the other eye.

            • After placing Xiidra (lifitegrast) in your eye, close your eye and press one finger to the inner corner of your eye by the nose for a couple minutes. This helps your eye absorb the drop and that not too much medication drains into your tear duct.

              • Throw away the Xiidra (lifitegrast) container after using it, even if there's some medication left. It doesn't have any preservatives in it. This can make it easier for germs to grow in any leftover medication. Using it again could lead to eye infections.

                • If you need to use another eye medication with Xiidra (lifitegrast), wait at least 5 minutes between them. This gives your eye time to absorb each medication.

                  faqs

                  Frequently asked questions about Xiidra (lifitegrast)

                  Is Xiidra (lifitegrast) a steroid?
                  No, Xiidra (lifitegrast) isn't a steroid eye drop. Instead, it's a different kind of medication called an LFA-1 antagonist. Both steroid eye drops and Xiidra (lifitegrast) help lower inflammation in the eye. But they work in different ways. Steroids block many inflammatory chemicals. But Xiidra (lifitegrast) blocks one specific protein called LFA-1 that plays a role in eye inflammation.
                  Does Xiidra (lifitegrast) cause hair loss?
                  In studies, hair loss wasn't a reported side effect of Xiidra (lifitegrast). If you notice hair loss while using this medication, talk to your primary care provider. They can check to see if something else is causing it.
                  How long does Xiidra (lifitegrast) stay in your system?
                  Xiidra (lifitegrast) doesn't really stay in your system. This is because only a small amount gets absorbed into your body after you place a drop in the eye. Talk to your prescriber if you have other questions about this.
                  Do Xiidra (lifitegrast) side effects go away?
                  Yes. Side effects from Xiidra (lifitegrast) usually go away soon after using the eye drops. These can include eye irritation, a strange taste in the mouth, and unclear or blurry vision. In a study, people said that blurry vision went away within minutes. Most times, these side effects also tend to be mild to moderate. If you have any side effects that bother you or don't go away, talk to your prescriber.
                  How long does it take for Xiidra (lifitegrast) to work?
                  In studies, some people reported having improvement in their dry eye symptoms in as early as 2 weeks of starting Xiidra (lifitegrast). For others, it can take up to 6 weeks or more to get the full effects of the medication. Keep in mind that you should be using Xiidra (lifitegrast) every day for it to work the best it can. Ask your prescriber if you have questions about how long it should take the medication to help with your dry eye.
                  Can you use artificial tears with Xiidra (lifitegrast)?
                  There are no known problems with using Xiidra (lifitegrast) and artificial tears together. It might take a few weeks of regular use for Xiidra (lifitegrast) to start improving dry eye symptoms. So in the meantime, it might be helpful to use artificial tears for instant (but temporary) relief. If you use both, make sure to wait at least 5 minutes between them to give your eyes time to absorb each medication. Keep in mind that using artificial tears too often or for too long might also cause problems. Ask your prescriber if using artificial tears with Xiidra (lifitegrast) is right for you.
                  Can Xiidra (lifitegrast) damage your eyes?
                  Eye damage from Xiidra (lifitegrast) isn't a common concern. Still, take care to put the eye drops in correctly. This helps avoid scratching or damaging your eye.
                  What's the difference between Xiidra and Restasis?
                  Xiidra (lifitegrast) and Restasis (cyclosporine) both eye drops for dry eye. They're both used twice a day every day. But the two medications do have some differences. This includes how fast they might relieve dry eye and what side effects they might cause. In a study, some people might feel symptom relief as early as 2 weeks after starting Xiidra. In another study, some people used Restasis for a month or longer before they started feeling better. Restasis can also cause a severe burning feeling in the eyes. This side effect doesn't seem to happen as often or be as bad with Xiidra. Xiidra has a balance of electrolytes and water that similar to that of natural tears. This might be the reason why it feels more gentle with Xiidra. Talk to your prescriber to compare the medications.
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                  What are the risks and warnings for Xiidra (lifitegrast)?

                  Xiidra (lifitegrast) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                  risk-warning

                  Risk of contamination

                  Remember to wash your hands before using Xiidra (lifitegrast). Don't touch the tip of the Xiidra (lifitegrast) container with your fingers. And don't let the tip touch your eye or any surface. These steps help prevent the medication from getting contaminated with germs. This lowers your chance of eye infection and injury to the eye.

                  dosage

                  Xiidra (lifitegrast) dosage forms

                  The average cost for 1 carton of 60 ampules of 5% of Xiidra (lifitegrast) is $681.60 with a free GoodRx coupon. This is 21.72% off the average retail price of $870.67.
                  carton
                  Carton
                  DosageQuantityPrice as low asPrice per unit
                  60 ampules of 5%1 carton$681.60$681.60

                  Typical dosing for Xiidra (lifitegrast)

                  The typical dose is 1 drop into each eye twice daily (about 12 hours apart).

                  drug-cost

                  How much does Xiidra (lifitegrast) cost?

                  To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
                  Xiidra (brand)
                  GoodRx lowest price

                  $681.60

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                  alternatives

                  What are alternatives to Xiidra (lifitegrast)?

                  There are a number of medications that your doctor can prescribe in place of Xiidra (lifitegrast). Compare a few possible alternatives below.
                  Xiidra (lifitegrast)
                  Used for:
                  $681.60 Lowest GoodRx priceView Prices
                  Artificial Tears
                  Used for:

                  • Dry eyes

                  • Prevention of eye irritation

                  $5.90 Lowest GoodRx priceView Prices
                  Cyclosporine (Restasis)
                  Used for:

                  • Dry eye in people 16 years and older

                  $97.64 Lowest GoodRx priceView Prices
                  images

                  Xiidra (lifitegrast) images

                  brown and yellow - Xiidra 5% Ophthalmic Solution
                  This medicine is Brown And Yellow Carton.brown and yellow - Xiidra 5% Ophthalmic Solution
                  brown and yellow - Xiidra 5% Ophthalmic Solution
                  This medicine is Brown And Yellow Carton.brown and yellow - Xiidra 5% Ophthalmic Solution
                  brown and yellow - Xiidra 5% Ophthalmic Solution
                  This medicine is Brown And Yellow Carton.brown and yellow - Xiidra 5% Ophthalmic Solution

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                  References

                  Best studies we found

                  Abidi, A., et al. (2016). Lifitegrast: A novel drug for treatment of dry eye disease. Journal of Pharmacology & Pharmacotherapeutics.

                  Atallah, R. T., et al. (2019). Six months' treatment with lifitegrast in patients with moderate-to-severe symptomatic dry eye: A retrospective chart review. Clinical Ophthalmology.

                  Bausch & Lomb. (2024). How to use Xiidra™ (lifitegrast ophthalmic solution) 5%.

                  View All References (8)

                  Bausch & Lomb Incorporated. (2024). Xiidra- lifitegrast solution/drops [package insert]. DailyMed.

                  Fung, A. T., et al. (2020). Local delivery of corticosteroids in clinical ophthalmology: A review. Clinical & Experimental Ophthalmology.

                  Haber, S. L., et al. (2019). Lifitegrast: A novel drug for patients with dry eye disease. Therapeutic Advances in Ophthalmology.

                  Holland, E. J., et al. (2017). Lifitegrast for the treatment of dry eye disease: Results of a phase III, randomized, double-masked, placebo-controlled trial (OPUS-3). Ophthalmology.

                  National Eye Institute. (2024). How to put in eye drops.

                  Nichols, K. K., et al. (2018). Safety and tolerability of lifitegrast ophthalmic solution 5.0%: Pooled analysis of five randomized controlled trials in dry eye disease. European Journal of Ophthalmology.

                  Rahman, M. Q., et al. (2006). Microbial contamination of preservative free eye drops in multiple application containers. The British Journal of Ophthalmology.

                  SafeMedication. (n.d.). How to use eye drops.

                  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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