Key takeaways:
Vyvanse (lisdexamfetamine) is a prescription-only stimulant medication. It’s approved to treat attention-deficit hyperactivity disorder (ADHD) and binge eating disorder.
Many Vyvanse interactions involve medications that affect serotonin levels, such as antidepressants, triptans, and opioids. Others are due to excess effects on the heart, such as Sudafed (pseudoephedrine), phentermine, and other stimulants.
Certain Vyvanse interactions can be managed with lower dosages and close monitoring. Others may need to be avoided completely. Your prescriber can best determine how to manage these potential Vyvanse interactions.
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For many people with attention deficit-hyperactivity disorder (ADHD), Vyvanse (lisdexamfetamine) is a helpful tool for staying focused and on task during the day. But when Vyvanse is taken with certain medications, interactions — ranging from mild to severe — can happen. Knowing about interactions in advance can help you avoid unwanted side effects or other issues.
Vyvanse interactions at a glance
Below is a list of potential Vyvanse interactions. But keep in mind that other interactions are possible. Before you start taking Vyvanse, provide your prescriber and pharmacist with a current list of your medications. They can work to prevent or minimize potential Vyvanse interactions before they occur.
Vyvanse interactions include:
Monoamine oxidase inhibitors (MAOIs)
Selective serotonin reuptake inhibitors (SSRIs)
Serotonin and norepinephrine reuptake inhibitors (SNRIs)
Tricyclic antidepressants (TCAs)
Wellbutrin (bupropion)
Triptan migraine medications
Opioid pain medications
Other stimulant medications
St. John’s wort
Lamisil (terbinafine)
Quinidine
Urine alkalinizers, such as Cytra-K (potassium citrate / citric acid)
Urine acidifiers, such as K-Phos (potassium phosphate)
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Let’s take a closer look at eight of these Vyvanse interactions below.
1. MAOIs
MAOIs are an older class of antidepressants. They’re used to treat depression or symptoms of Parkinson’s disease. Examples include:
Emsam (selegiline)
Azilect (rasagiline)
Nardil (phenelzine)
You shouldn’t take Vyvanse with any MAOI, or for at least 14 days after stopping treatment with an MAOI. This combination can result in dangerously high blood pressure.
Vyvanse and MAOIs both increase levels of a hormone called serotonin. And combining them can put you at risk for serotonin syndrome. This is a potentially life-threatening condition caused by too much serotonin in the body. Serotonin syndrome is more likely if you’re taking multiple medications that increase serotonin levels. As you’ll see, serotonin syndrome is a common concern with Vyvanse interactions, so we’ll cover more about this condition below.
2. SSRIs, such as Zoloft
SSRIs are commonly used to treat mental health conditions, such as depression and anxiety. They work by making more serotonin available in your brain. Examples include:
While rare, taking Vyvanse with an SSRI may lead to serotonin syndrome. Symptoms of serotonin syndrome range from mild to severe. Examples include tremors (shakiness), a fast heart rate, and sweating. Fever and confusion are also possible.
If you need to take Vyvanse and an SSRI together, your prescriber may start you with a lower Vyvanse dosage. Tell them right away if you think you’re experiencing symptoms of serotonin syndrome. If your symptoms are severe or seem to be worsening, seek emergency medical care.
3. SNRIs, such as Effexor
There are some similarities between SNRIs and SSRIs. They’re often taken for mental health conditions, and some can also treat pain. Examples of SNRIs include:
Effexor (venlafaxine)
Cymbalta (duloxetine)
Pristiq (desvenlafaxine)
ADHD treatment options: Learn the difference between stimulant and non-stimulant medications, and how to choose between them when treating ADHD.
Generic Vyvanse FAQs: What you need to know about generic Vyvanse options and tips for accessing them.
Vyvanse side effects: From loss of appetite to heart issues, learn more about possible Vyvanse side effects and what to do if they occur.
Just like SSRIs, SNRIs make more serotonin available in the brain. But, like Vyvanse, they also increase norepinephrine levels.
Combining Vyvanse and an SNRI can put you at increased risk of serotonin syndrome. As a precaution, your prescriber may start you with a lower Vyvanse dosage. But tell them right away if you develop symptoms of serotonin syndrome.
Since Vyvanse and SNRIs increase norepinephrine, they can both also raise your heart rate and blood pressure. Taking them together can worsen this effect. Based on your health history, your prescriber can decide if this combination is OK for you to take. They may recommend taking an SSRI instead of an SNRI, for example, since SSRIs don’t affect your heart rate or blood pressure.
4. Wellbutrin (bupropion)
Wellbutrin is another type of antidepressant. You can take it alone or in combination with other medications.
Wellbutrin and Vyvanse can both increase your blood pressure. This effect may be more pronounced if they’re taken together. Similar to combining an SNRI and Vyvanse, your prescriber can decide if this combination is safe for you to take. They may recommend an alternative medication or choose to monitor your blood pressure closely during treatment.
5. Triptan migraine medications
Triptan medications are used to treat migraine headaches. They attach to serotonin receptors (binding sites) in your brain and other parts of your body. Examples include:
Imitrex (sumatriptan)
Zomig (zolmitriptan)
Maxalt (rizatriptan)
Relpax (eletriptan)
Combining Vyvanse and a triptan medication can increase your risk of serotonin syndrome. But you typically only take triptans as needed for acute migraines, not as a daily medication. So the risk of this side effect may be lower than with other medications. But it’s still important to watch for symptoms of serotonin syndrome and contact your prescriber as soon as possible if they occur. If needed, they can discuss alternative migraine medications with you.
6. Opioid pain medications, such as tramadol
Tramadol is a prescription-only opioid medication used to treat pain. It’s one of several opioid medications known to increase serotonin levels. The effects on serotonin may vary between opioids. But all of them carry a risk of causing serotonin syndrome when combined with Vyvanse or other medications that raise serotonin levels.
Your prescriber will determine if it’s OK for you to take Vyvanse with an opioid medication. If so, they may have you keep an eye out for symptoms of serotonin syndrome. They may also suggest non-opioid pain relievers and other tips for managing pain.
7. Blood pressure medications
As mentioned above, Vyvanse can increase your blood pressure, which may be more pronounced in some people. If you’re taking medications to manage your blood pressure, they may not work as well with Vyvanse.
If you have high blood pressure or any other heart-related health conditions, let your healthcare team know before starting Vyvanse. They can decide if it’s safe for you based on your personal history. If they do prescribe you Vyvanse, they may want to monitor your blood pressure during treatment, making adjustments to your medications as needed. They may also ask you to check your blood pressure at home and let them know if any readings are higher than normal.
But if you develop chest pain, trouble breathing, or notice your heart beating differently than usual while taking Vyvanse, seek emergency care right away.
8. Other stimulants, such as Sudafed and Adipex-P
As discussed, Vyvanse is a stimulant medication. Other examples of stimulants include many other ADHD medications, some weight-loss pills such as Adipex-P (phentermine), and decongestants such as Sudafed (pseudoephedrine).
It’s best to avoid combining Vyvanse with other stimulant medications unless your prescriber recommends it. Taking multiple stimulants can increase your blood pressure and heart rate. You may also be more likely to experience side effects such as insomnia and anxiety. Dangerously high blood pressure and irregular heartbeats are also possible.
Good to know: The caffeine in your morning coffee or energy drink is also a stimulant. So it may also be best to limit or avoid caffeine while taking Vyvanse. Check out a few non-caffeinated tips to get your day started with natural energy.
Do any vitamins or supplements interact with Vyvanse?
Yes, some over-the-counter (OTC) vitamins and supplements can interact with Vyvanse. St. John’s wort can raise serotonin levels, similar to an SSRI or SNRI. So there’s a risk for serotonin syndrome if you take it with Vyvanse. And large amounts of vitamin C may increase the acidity of your urine, which can lower Vyvanse levels in the body. This issue is more likely with vitamin C supplements than with fruits or juices that contain vitamin C.
Can you take Vyvanse and Ozempic together?
Yes, it’s generally OK to take Vyvanse and Ozempic (semaglutide) together. But you may notice that you have less of an appetite, since both medications can affect how hungry you feel. In this case, make sure you’re getting adequate nutrition by eating nutrient-dense foods.
In addition to ADHD, Vyvanse is used to treat binge eating disorder. Some experts think that medications like Ozempic may also be able to play a role in treating binge eating disorder. But more research is needed to know for sure, and the two medications haven’t been studied together for this purpose. Your prescriber can weigh the benefits and risks of this combination.
Can you drink alcohol while taking Vyvanse?
It’s usually best to avoid or minimize alcohol consumption while taking Vyvanse. Vyvanse has stimulant effects, while alcohol has depressant effects. So the two substances can counteract each other. This combination can also increase the risk of alcohol poisoning and worsen side effects, such as increased blood pressure.
Frequently asked questions
In most cases, it’s best to avoid combining Vyvanse with another stimulant ADHD medication, such as Adderall (mixed amphetamine salts). These medications work very similarly to each other. So there may be a higher risk of side effects (without additional benefits) if you take them at the same time. However, it’s possible that your prescriber may recommend that you take Vyvanse in the morning, then immediate-release (IR) Adderall later in the day as Vyvanse wears off. But you shouldn’t attempt to do this without your prescriber’s guidance.
No, there’s no interaction between the antibiotic amoxicillin (Amoxil) and Vyvanse. It’s fine to take these medications together. But both medications can cause nausea as a side effect, so it's a good idea to take them with food.
Yes, according to the manufacturer, you can open Vyvanse capsules and mix the contents with orange juice if you can’t swallow the pills whole. Other suggested options for mixing include yogurt and water.
In most cases, it’s best to avoid combining Vyvanse with another stimulant ADHD medication, such as Adderall (mixed amphetamine salts). These medications work very similarly to each other. So there may be a higher risk of side effects (without additional benefits) if you take them at the same time. However, it’s possible that your prescriber may recommend that you take Vyvanse in the morning, then immediate-release (IR) Adderall later in the day as Vyvanse wears off. But you shouldn’t attempt to do this without your prescriber’s guidance.
No, there’s no interaction between the antibiotic amoxicillin (Amoxil) and Vyvanse. It’s fine to take these medications together. But both medications can cause nausea as a side effect, so it's a good idea to take them with food.
Yes, according to the manufacturer, you can open Vyvanse capsules and mix the contents with orange juice if you can’t swallow the pills whole. Other suggested options for mixing include yogurt and water.
The bottom line
Vyvanse (lisdexamfetamine) can interact with medications that affect serotonin, including antidepressants, opioid pain medications, and triptans. It can also interact with other stimulants and blood pressure medications.
Your prescriber will determine if you can safely take another medication with Vyvanse. Talk to them or your pharmacist if you have questions about potential Vyvanse interactions.
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References
AvKARE. (2025). Lisdexamfetamine Dimesylate- lisdexamfetamine capsule [package insert].
Foong, A., et al. (2018). Demystifying serotonin syndrome (or serotonin toxicity). Canadian Family Physician.
National Institute on Drug Abuse. (2016). Is it safe to use prescription drugs in combination with other medications?. National Institutes of Health.
Stevens, J. R., et al. (2013). Using stimulants for attention-deficit/hyperactivity disorder: Clinical approaches and challenges. The Primary Care Companion for CNS Disorders
Takeda Pharmaceuticals America. (2023). Vyvanse - lisdexamfetamine dimesylate capsule, Vyvanse- lisdexamfetamine dimesylate tablet, chewable [package insert].
U.S. Department of Health and Human Services. (2016). Prescription stimulants. Facing Addiction in America: The Surgeon General's Report on Alcohol, Drugs, and Health.
U.S. Food and Drug Administration. (2016). FDA drug safety communication: FDA warns about several safety issues with opioid pain medicines; requires label changes.
