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Veozah Coupon - Veozah 45mg tablet

Veozah

fezolinetant
Used for Menopause
Used for Menopause

Veozah (fezolinetant) is a prescription treatment option for hot flashes and night sweats due to menopause. It belongs to the drug class called neurokinin 3 (NK3) receptor antagonists. Veozah (fezolinetant) is a hormone-free tablet that's usually taken by mouth once a day. Side effects include stomach pain, diarrhea, and trouble sleeping. Because of the risk for liver injury, this medication isn't recommended if you have long-term liver damage.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Cydnee Ng, PharmD
Last reviewed on March 10, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Veozah (fezolinetant)?

What is Veozah (fezolinetant) used for?

How Veozah (fezolinetant) works

Veozah (fezolinetant) is a neurokinin 3 (NK3) receptor antagonist. It blocks a chemical in the brain called neurokinin B from causing hot flashes (episodes of sweating and feeling hot).

When does Veozah (fezolinetant) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsVeozah
Drug ClassNeurokinin 3 receptor antagonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Veozah (fezolinetant) essentials

Veozah: woman researching on tablet 1401269014

7 Things to Know About Veozah (Fezolinetant), the Hormone-Free Menopause Medication

Written by Dima Cheetany, PharmD
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What are the side effects of Veozah (fezolinetant)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Stomach pain (4%)
  • Diarrhea (4%)
  • Trouble sleeping (4%)
  • Back pain (3%)
  • Hot flush (3%)
  • Higher liver labs, suggesting liver irritation (2%)

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious liver damage: nausea, vomiting, stomach pain, yellowing of the skin or whites of the eyes, clay-colored stools
When do Veozah (fezolinetant) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Stomach pain
Diarrhea
Trouble sleeping
Serious liver damage
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Veozah (fezolinetant)

thumbs-up

Pros

Only taken once a day

Works well to lessen how often you have hot flashes from menopause and lower how severe your symptoms are

Hormone-free treatment option

Can take with or without food

thumbs-down

Cons

Brand name only

Might cause unpleasant side effects, like stomach pain, diarrhea, and back pain

Requires lab work every few months for the first 9 months to check liver health

Not recommended for people with severe kidney or liver problems

pharmacist-tips

Pharmacist tips for Veozah (fezolinetant)

pharmacist

  • Swallow Veozah (fezolinetant) tablets whole with a drink. Don't cut, crush, or chew the tablets because this could damage the medication.

    • Take Veozah (fezolinetant) at the same time every day so the amount of medication in your body stays consistent.

      • Before you start Veozah (fezolinetant), your prescriber will order lab work to check your liver health. Once you start the medication, you'll continue to need lab work done every 3 months until the 9th month of treatment. Veozah (fezolinetant) can sometimes affect the liver, so these lab tests help check that the medication is safe for you to take.

        • If you miss a dose of Veozah (fezolinetant), take it as soon as possible. If your next dose is less than 12 hours away, skip the missed dose and continue with your normal dosing schedule.

          faqs

          Frequently asked questions about Veozah (fezolinetant)

          Does Veozah (fezolinetant) cause weight gain?
          Weight gain wasn't a side effect that was commonly reported by people who took Veozah (fezolinetant) during 1-year clinical studies. Keep in mind that changes in weight — often weight gain — can be common during menopause. Have a discussion with your prescriber or primary care provider if you've noticed unexplained weight gain while you're taking this medication.
          Does Veozah (fezolinetant) help with weight loss?
          Weight loss wasn't reported during clinical studies of Veozah (fezolinetant), and this medication hasn't been studied for weight loss. Work with your primary care provider to come up with a plan that best fits you if you need help with losing weight.
          How well does Veozah (fezolinetant) work?
          In two clinical studies, people who had reached menopause had about an average of 50% fewer hot flashes each day after they took Veozah (fezolinetant) for 4 weeks. In comparison, people who took a placebo for the same amount of time had on average a 30% reduction in the number of hot flashes per day. Additionally, those who took Veozah (fezolinetant) experienced less severe hot flashes than those taking a placebo.
          How long does it take for Veozah (fezolinetant) to work?
          You should start to notice an improvement in your hot flash symptoms within 1 week of starting Veozah (fezolinetant). Keep in mind that everyone can respond to the medication differently. Keep track of how often and how severe your hot flashes are while you're taking this medication. Follow up with your prescriber or primary care provider about your hot flash symptoms and whether Veozah (fezolinetant) seems to be helping.
          Can you take Veozah (fezolinetant) with estrogen?
          There isn't enough information to know how safe it is to take Veozah (fezolinetant) together with estrogen, a common ingredient in hormone replacement therapy (HRT) for menopause. Estrogen gets broken down in the body by the same protein in the liver as Veozah (fezolinetant). This means that Veozah (fezolinetant) and estrogens might interact with each other and affect how well they work or affect the risk for side effects. Ask your healthcare team whether taking both is a safe option for you.
          Does Veozah (fezolinetant) interact with any medications?
          Yes. Veozah (fezolinetant) is broken down by certain enzymes (proteins) in the liver. Some medications can block how well these enzymes work; taking these types of medications together with Veozah (fezolinetant) can cause Veozah (fezolinetant) to build up in your body and lead to more side effects. Some examples of medications that interact with Veozah (fezolinetant) include fluvoxamine (Luvox), mexiletine, and cimetidine (Tagamet HB). Review your current list of medications with your healthcare team. The care team can help check for potential interactions with Veozah (fezolinetant).
          Can you drink alcohol while you're taking Veozah (fezolinetant)?
          Discuss with your healthcare team about whether it's safe to drink alcohol while you're taking Veozah (fezolinetant). In general, alcohol can have negative effects on your body, including liver damage. Because Veozah (fezolinetant) can also affect your liver, the risk for liver injury might be higher if you drink alcohol while you're taking the medication, especially if you tend to drink a lot of alcohol. Additionally, drinking alcohol could make some people have more hot flashes.
          Is there a generic for Veozah (fezolinetant)?
          No. Currently, Veozah (fezolinetant) is only available as a brand-name medication.
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          What are the risks and warnings for Veozah (fezolinetant)?

          Veozah (fezolinetant) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

          risk-warning

          Liver irritation

          In clinical studies, some people who took Veozah (fezolinetant) had results on their blood tests that showed higher liver enzyme levels, which can be a sign that the liver is irritated or damaged. Among those who had these abnormal lab results, most people didn't have noticeable symptoms of liver damage. Lab results generally returned to usual when people continued taking, paused, or stopped the medication altogether.

          To be safe, your prescriber will order blood tests before you start Veozah (fezolinetant) to check the health of your liver. You'll also need to have your blood tested every 3 months after you start this medication until the 9th month of treatment. Get medical attention right away if you experience signs of liver damage, such as nausea, vomiting, stomach pain, or yellowing of the skin or whites of the eyes.

          dosage

          Veozah (fezolinetant) dosage forms

          The average cost for 30 tablets of 45mg of Veozah (fezolinetant) is $478.29 with a free GoodRx coupon. This is 28.66% off the average retail price of $670.45.
          tablet
          Tablet
          DosageQuantityPrice as low asPrice per unit
          45mg30 tablets$478.29$15.94

          Typical dosing for Veozah (fezolinetant)

          The typical dose is 45 mg by mouth once a day.

          More on Veozah (fezolinetant) dosage forms

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          contraindications-icon

          Veozah (fezolinetant) contraindications

          Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Veozah (fezolinetant) will not be safe for you to take.

          • Currently have long-term liver damage (cirrhosis)

          • Currently have severe kidney problems or end-stage kidney disease

          • Take medications known as CYP1A2 inhibitors

          alternatives

          What are alternatives to Veozah (fezolinetant)?

          There are a number of medications that your doctor can prescribe in place of Veozah (fezolinetant). Compare a few possible alternatives below.
          Veozah (fezolinetant)
          Used for:
          $478.29 Lowest GoodRx priceView Prices
          Femhrt (ethinyl estradiol / norethindrone)
          Used for:

          • Moderate-to-severe symptoms of menopause (hot flashes and night sweats)

          • Prevention of osteoporosis in women who've reached menopause

          $62.13 Lowest GoodRx priceView Prices
          Paroxetine (Brisdelle)
          Used for:
          $53.11 Lowest GoodRx priceView Prices
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          Veozah (fezolinetant) images

          Red Round Logo 645 - VEOZAH 45mg Tablet
          This medicine is Red, Round Tablet Imprinted With "Logo 645".Red Round Logo 645 - VEOZAH 45mg Tablet

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          References

          Best studies we found

          Astellas Pharma US, Inc. (2023). VEOZAH- fezolinetant tablet, film coated [package insert]. DailyMed.

          Jayasena, C. N., et al. (2015). Neurokinin B administration induces hot flushes in women. Scientific Reports.

          Johnson, K.A., et al. (2023). Efficacy and safety of fezolinetant in moderate to severe vasomotor symptoms associated with menopause: A phase 3 RCT. The Journal of Clinical Endocrinology & Metabolism.

          View All References (5)

          Lu, J., et al. (2020). New insights of CYP1A in endogenous metabolism: A focus on single nucleotide polymorphisms and diseases. Acta Pharmaceutica Sinica B.

          National Institute on Aging. (2021). Hot flashes: What can I do?

          The North American Menopause Society. (n.d.). Drink to your health at menopause, or not?

          U.S. Food and Drug Administration. (2023). For healthcare professionals | FDA’s examples of drugs that interact with CYP enzymes and transporter systems.

          U.S. Food and Drug Administration. (2023). FDA approves novel drug to treat moderate to severe hot flashes caused by menopause.

          GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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