Veklury
Veklury (remdesivir) is an intravenous (IV) medication used to treat coronavirus disease 2019 (COVID-19) in certain people. It was FDA-approved in October 2020 during the coronavirus pandemic. While the medication was originally only approved for people aged 12 years and older, Veklury (remdesivir) can now be used for people as young as 28 days old. Veklury (remdesivir) is only given in a hospital or a clinic.
What is Veklury (remdesivir)?
What is Veklury (remdesivir) used for?
Treatment of COVID-19 infection in people aged 28 days or older and weigh at least 3 kg (6.6 lbs), and are either:
- Hospitalized or
- Not hospitalized but have mild-to-moderate COVID-19 and are at high risk of developing severe COVID-19
How Veklury (remdesivir) works
Veklury (remdesivir) is a SARS-CoV-2 nucleotide analog RNA polymerase inhibitor. It blocks a protein that the COVID-19 virus needs to make copies of itself and grow.
More specifically, Veklury (remdesivir) looks like one of the building blocks of RNA. RNA is the genetic material of SARS-CoV-2 (the virus that causes COVID-19). When Veklury (remdesivir) is present, it can get pulled into the virus’ RNA when it tries to replicate and spread. This prevents the COVID-19 virus from spreading because it used the wrong building material.
Drug Facts
What are the side effects of Veklury (remdesivir)?
Common Side Effects
- Nausea
- Changes in liver blood tests
Other Side Effects
- Allergic reactions: rash, sweating, fever, changes in heart rate
Serious Side Effects
- Serious allergic reactions: shortness of breath, changes in heart rate, rash, swelling of your lips, face, tongue, or throat
- Liver problems: nausea, vomiting, dark urine, yellowing of your eyes or skin (jaundice), poor appetite, pain in the upper right side of your stomach
- Seizure
Source: DailyMed
More on Veklury (remdesivir) side effects
The following side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Infusion reactions—chest pain, shortness of breath or trouble breathing, feeling faint or lightheaded
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
Pros and cons of Veklury (remdesivir)
Pros
Second-choice option for certain people who aren't hospitalized at risk of severe COVID-19
Expected to work against the Omicron variant and the BA.2 subvariant
Can be used for people who are hospitalized and certain people who aren't hospitalized
Cons
If the medication is received at a clinic, requires travel to the clinic on 3 back-to-back days
Given through an IV infusion
Can cause serious allergic reactions
Pharmacist tips for Veklury (remdesivir)
Veklury (remdesivir) is given by a healthcare provider at the hospital or clinic. Your provider will monitor you for any side effects while you receive the medication and for at least 1 hour afterwards in case of an allergic reaction .
Veklury (remdesivir) is given through an infusion into your veins. The infusion can take 30 to 120 minutes. Your provider will decide how long your infusion will take. The length of your infusion depends on whether you're at risk of a potential allergic reaction.
The total duration of your Veklury (remdesivir) treatment depends on the how severe your condition is and if you're hospitalized or not. If you're not hospitalized, you'll need to travel to the clinic to receive the medication on 3 back-to-back days.
It's important that you practice CDC-recommended safety measures to protect yourself and others from either getting or spreading the COVID-19 virus.
Veklury (remdesivir) can cause serious allergic reactions. Let your provider know if you experience a rash, shortness of breath, changes in your heart rate, or swelling of your lips, face, tongue, or throat.
Frequently asked questions about Veklury (remdesivir)
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What are the risks and warnings for Veklury (remdesivir)?
Veklury (remdesivir) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Serious allergic reactions
Veklury (remdesivir) can cause serious allergic reactions, such as changes in blood pressure or heart rate, low oxygen levels, trouble breathing, wheezing, sweating, rash, and swelling of your face, lips, tongue, or throat. Most of these reactions have occurred within one hour of receiving the medication. Depending on your risk for these reactions, you might need to receive your Veklury (remdesivir) infusions for a longer period of time. Your provider will monitor you for signs and symptoms during and after your treatment for at least one hour.
Liver damage
Veklury (remdesivir) can cause changes in your liver tests, which can be a sign of liver problems. Because of this risk, your provider will likely have you do blood work to monitor your liver before and during your treatment. If you develop any symptoms of liver damage, such as dark urine, pain in the upper right area of your stomach, jaundice, or loss of appetite, let your provider know right away.
Interactions with other medications
Veklury (remdesivir) can interact with other medications, including chloroquine and hydroxychloroquine (Plaquenil). Taking these medications with Veklury (remdesivir) can affect how well the drug works against the COVID-19 virus. Be sure your provider knows all of the medications you are taking, including vitamins and herbal supplements, before you receive Veklury (remdesivir).
Veklury (remdesivir) dosage forms
Typical dosing for Veklury (remdesivir)
Veklury (remdesivir) is given by a healthcare provider in the hospital or clinic.
People who weigh 40 kg (88 lbs) and above: The typical dose is a one-time dose (loading dose) of 200 mg infused through your veins (IV) on day 1. On day 2 and each day after, you'll receive 100 mg infused through your veins.
Children who weigh 3 kg (6.6 lbs) to less than 40 kg (88 lbs): The dose will depend on your child's weight. The typical dose is a one-time dose of 5 mg/kg infused through their veins (IV) on day 1. On day 2 and each day after, they will receive 2.5 mg/kg infused through their veins.
The total number of days you receive treatment will depend on if you're in the hospital or clinic, and how severe your condition is.
What are alternatives to Veklury (remdesivir)?
Treatment of COVID-19 infection in people aged 28 days or older and weigh at least 3 kg (6.6 lbs), and are either:
- Hospitalized or
- Not hospitalized but have mild-to-moderate COVID-19 and are at high risk of developing severe COVID-19
Mild-to-moderate COVID-19 in people 12 years and older (and weighing over 88 lbs) who are at high risk for severe illness
What is the latest news about Veklury (remdesivir)?
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