5 Vascepa Side Effects and How to Manage Them

Omega-3 fatty acid pills are commonly found over the counter (OTC). But some of them, such as Vascepa (icosapent ethyl), require a prescription. Vascepa contains a specific omega-3 fatty acid called eicosapentaenoic acid. If you have very high triglycerides (a type of fat in the blood), it’s an option your healthcare provider may consider.

Despite its benefits, Vascepa has several side effects to be aware of. Muscle and joint pain, swelling, and constipation are common complaints. Bleeding is also possible, especially if you take Vascepa with blood thinners. We cover what you should know about five Vascepa side effects below.

1. Muscle, joint, and throat pain

Muscle and joint pain are common Vascepa side effects. But it’s important to note that muscle and joint pain are also reported with statins, which may be prescribed with Vascepa. Throat pain (or a sore throat) is also possible with both medications.

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In general, muscle and joint pain should improve over time for most people. If it’s bothersome, you can try applying heat or ice for some relief. Your healthcare provider may also recommend taking an OTC pain reliever. And if a statin is the cause, they can suggest several options, such as a lower dose, to help you stick with treatment.

If you’re also taking a statin, muscle pain with dark-colored urine and weakness can be signs of serious muscle damage. This can result in kidney failure, especially if left untreated. Go to the nearest emergency room if these symptoms develop.

Good to know: During clinical trials, some people developed gout while taking Vascepa. This is a painful type of arthritis that usually affects your big toe and knees, but may also affect other joints in your body. Contact your healthcare provider if you develop very painful and swollen joints.

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2. Swelling

Swelling, or edema, is a possible Vascepa side effect. Symptoms often include puffy feet, legs, or hands. This is usually due to fluid buildup in the swollen area. Keep in mind that medications are only one possible cause of swelling. Some medical conditions, like heart failure and kidney disease, can also cause swelling.

How you treat swelling depends on the cause, but possible treatments include compression socks, a low-salt diet, and diuretics (“water pills”). If a medication is causing the swelling, stopping it may help. But don’t stop or change your medications without your healthcare provider’s approval.

In some cases, swelling can be more concerning, especially if it’s accompanied by shortness of breath. So, let your healthcare provider know right away if it happens. They can help determine the cause and how to treat it.

3. Constipation

Some people taking Vascepa experience constipation. But keep in mind that many things can cause constipation. For example, certain diet and exercise habits can contribute to constipation. Statins and other medications are another potential culprit. If you experience new or worsening constipation after starting Vascepa, the medication may be a cause.

Taking measures to prevent constipation can help. This includes eating a high-fiber diet, exercising regularly, and drinking plenty of water. Keeping a regular schedule for bowel movements and using the bathroom when you feel the urge can also help.

Treatments for constipation such as stool softeners, fiber supplements, and laxatives are another option, if recommended by your healthcare provider. If you have constipation that’s bothersome or doesn’t resolve, let your care team know. They can recommend the best treatment in your situation to relieve your symptoms.

4. Abnormal heart rhythm

Vascepa has been linked to an increased risk of abnormal heart rhythms, like atrial fibrillation. This risk is higher in people who’ve had a heart rhythm condition in the past. Common symptoms include a fast or irregular heartbeat, lightheadedness, and shortness of breath.

If you develop any of these symptoms, let your healthcare provider know. They can help determine whether you need further treatment. But if any symptoms feel severe or life threatening, go to the nearest emergency room.

5. Bleeding

Bleeding was reported by people taking Vascepa during clinical trials. However, evidence is conflicting as to whether it actually increases the risk of bleeding.

Even so, it’s still a good idea to watch for unusual bruising or bleeding if you’re taking Vascepa. This is especially the case if you’re taking it with anticoagulant or antiplatelet medications. Your healthcare provider and pharmacist can review your current medication list for these interactions ahead of time.

If you experience abnormal bleeding while taking Vascepa, let your healthcare provider know. Mild bleeding, such as gum bleeding, can be handled safely at home. But if they continue to happen, your medications may need to be adjusted. Serious bleeding like blood in the urine or stool or bleeding that won’t stop may require emergency medical care.

When should you contact your healthcare provider about Vascepa side effects?

It’s a good idea to ask your healthcare provider about Vascepa side effects before you start taking the medication. But if you’re already taking it, don’t hesitate to reach out if you have questions. Your pharmacist can also be a helpful resource for discussing Vascepa side effects.

If you have mild side effects like general aches and pains or mild constipation, these can often be resolved at home. But if you have symptoms such as swelling, shortness of breath, or abnormal bleeding, check with your healthcare provider. You may need further treatment to manage these symptoms.

How to save on Vascepa

There are ways to save on Vascepa, which is available as a generic- and brand-name medication. GoodRx can help you navigate between GoodRx coupons and copay savings cards to save money on your prescription.

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Written by:

Austin Ulrich, PharmD, BCACP

Austin Ulrich, PharmD, BCACP, is a board-certified ambulatory care clinical pharmacist. In his early career, he provided direct patient care in a variety of settings, including hospital and community pharmacies, and in a primary care clinic as a clinical pharmacist.

Edited by:

Alyssa Billingsley, PharmD

Alyssa Billingsley, PharmD, is the director of pharmacy content for GoodRx. She has over a decade of experience as a pharmacist and has worked in clinical, academic, and administrative roles.

Reviewed by:

Christina Aungst, PharmD

Christina Aungst, PharmD, is a pharmacy editor for GoodRx. She began writing for GoodRx Health in 2019, transitioning from freelance writer to editor in 2021.

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