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Vanrafia

Vanrafia Side Effects

Emma Scholes, PharmD CandidateCydnee Ng, PharmD
Reviewed by Emma Scholes, PharmD Candidate, Cydnee Ng, PharmD, Daisy Chau, PharmD
Last reviewed on October 27, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Swelling of the arms or legs (10%)
  • Low red blood cells (anemia, 6%)

Less Common Side Effects

Vanrafia serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious liver problems: nausea, vomiting, pain in the upper right side of the stomach, decreased appetite, dark urine, yellowing of your skin or the whites of your eyes, tiredness, fever, itching
  • Fluid buildup: unexplained weight gain, swelling in your ankles or legs, trouble breathing
When do Vanrafia possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Swelling of the arms and legs
Low red blood cells
High liver enzyme levels
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: FDA

The following Vanrafia side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Swelling of the ankles, hands, or feet
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