Ultomiris Dosage

Treatment starts with a loading dose of Ultomiris.

• Loading dose: The loading dose is given as an infusion into the veins (intravenous or IV) as a single dose. Your prescriber will calculate your dose based on why you need the medication and your age and weight.

Treatment continues with routine maintenance doses of Ultomiris, generally starting 2 weeks after the loading dose.

• Maintenance doses: Maintenance doses are typically given as IV infusions. Certain adults have the option of getting maintenance doses as injections under the skin (subcutaneous or SC).
  • IV infusion: Your prescriber will calculate your dose based on your condition, age, and weight. After the first maintenance dose, Ultomiris is given once every 1 or 2 months.
  • SC injection (certain adults only): Maintenance doses given under the skin are only for adults with PNH or aHUS who weigh at least 88 lbs. The typical dose is 490 mg injected under the skin. After the first maintenance dose, Ultomiris is injected under the skin once per week.

You might need an extra (supplemental) dose of Ultomiris if your treatment plan includes plasmapheresis, plasma exchange, or IV immunoglobulin. These therapies can lower the amount of Ultomiris in your body.