Key takeaways:
Ubrelvy (ubrogepant) is an oral tablet that treats symptoms of a migraine attack. The usual Ubrelvy dosage is 50 mg or 100 mg when migraine symptoms start. In most cases, you can take another dose 2 hours later if symptoms are still present.
If you have severe liver or kidney problems, you may need to limit Ubrelvy doses to 50 mg. And if you take medications that interact with Ubrelvy, your healthcare team may give you specific dosage instructions.
There are ways to save on Ubrelvy. If you’re eligible, a manufacturer savings card can help you access Ubrelvy for free. A patient assistance program is also available.
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Ubrelvy (ubrogepant) is an oral medication that treats migraine attacks. Migraines are a medical condition of the brain. They often involve headaches. They can also cause sensitivity to light and sound, nausea, and vision changes.
Ubrelvy is part of a group of medications called calcitonin gene-related peptide (CGRP) receptor blockers. These medications work by blocking a protein that’s released during migraine attacks. And they’re relatively new, with the first CGRP receptor blocker being approved in 2018 under the brand-name Aimovig (erenumab). Ubrelvy was FDA approved in 2019.
In this guide, we’ll review typical Ubrelvy dosages. These are the FDA-approved, manufacturer-recommended doses that you’d find in the prescribing information for Ubrelvy. But if your prescriber recommends a different dose, make sure you understand their recommendation and follow it closely.
Good to know: Ubrelvy isn’t approved for children and teens under age 18. So this article will only discuss adult dosages for the medication.
What’s the typical Ubrelvy dosage for adults?
Ubrelvy is meant to treat migraine attacks as they occur. But it doesn’t prevent migraines.
If you’re prescribed Ubrelvy, you can take a dose as soon as you first experience migraine symptoms. These might include pain around the eyes, ears, or temples. It may also include nausea and sensitivity to light and sound.
The typical Ubrelvy dosage for adults is 50 mg or 100 mg taken when migraine symptoms start. But if you’re unable to take Ubrelvy right away, don’t worry. In clinical trials, people took Ubrelvy up to 4 hours after the start of migraine symptoms and still found it helpful.
If you still have migraine symptoms after 2 hours of your initial dose, you can take a second Ubrelvy dose. This dose is usually the same amount as your initial dose. But make sure it’s been at least 2 hours since your first dose. You shouldn’t take more than 2 doses in a 24-hour period.
Ubrelvy hasn’t been tested for use in more than 8 migraine attacks within any 30-day period. So be sure to keep track of how often you use Ubrelvy. If you’re having more than 8 migraines in a 30-day period, let your healthcare team know. You may need medication to help prevent migraines if you aren’t already taking one.
How do you take Ubrelvy?
Ubrelvy comes as a 50 mg or 100 mg tablet that you swallow. Foods that are high in fat may affect how quickly and how much medication your body absorbs. But studies of Ubrelvy looked at people that took it with and without food, and it was effective either way. So if you start having migraine symptoms, don’t worry about when you last ate — you can take Ubrelvy at any time, with or without food.
Are there any Ubrelvy dosage adjustments for medical conditions?
If you have certain medical conditions or take certain medications, you may need a lower or higher Ubrelvy dose.
Your prescriber will let you know if any of these dose changes apply to you. Don’t try to adjust your Ubrelvy dosage on your own.
Ubrelvy dosage for people with kidney problems
Your kidneys help your body get rid of Ubrelvy. If you have kidney disease, Ubrelvy may build up in the body and cause new or worsening side effects.
How fast does Ubrelvy work? Pharmacists answer this and other frequently asked questions about Ubrelvy (ubrogepant).
Things to avoid: Find out which Ubrelvy interactions require dosage changes to avoid problems.
Ways to save: Learn how much Ubrelvy costs without insurance, plus tips for wrangling savings.
If you have mild or moderate kidney issues, you’ll likely take the standard Ubrelvy dosage discussed above. If you have severe kidney problems, it’s recommended to take the 50 mg dose when migraine symptoms happen. But you can still take another dose 2 hours after your first dose, if needed. It’s not recommended to take the 100 mg tablets if you have severe kidney problems.
If you have end-stage kidney disease, you should avoid Ubrelvy.
Ubrelvy dosage for people with liver problems
Some people with liver damage also need a lowered Ubrelvy dosage. This is because your body relies on the liver to break down the medication after you take it. Ubrelvy may build up in the body if your liver is severely damaged. This can cause added side effects.
If you have severe liver cirrhosis (permanent scarring of the liver), you may need a lower Ubrelvy dosage (50 mg when a migraine starts). You can still take another 50 mg dose 2 hours after your first dose if you still have migraine symptoms. It’s not recommended to take the 100 mg tablets if you have severe liver cirrhosis problems.
Ubrelvy dosage for drug interactions
Ubrelvy has many drug interactions. Some of these interactions require dose adjustments. This could mean taking a different dose or not repeating doses during the same migraine. It could also mean avoiding Ubrelvy altogether.
Examples of some interactions are in the table below; but keep in mind, this isn’t a comprehensive list. Before you take Ubrelvy, let your prescriber and pharmacist know about all the medications and supplements you take. And let them know if you consume any grapefruit or grapefruit juice. They can help you check for drug interactions.
| Examples of medications | 1st Ubrelvy dose | 2nd Ubrelvy dose (at least 2 hours after first dose) | |
|---|---|---|---|
| Medications that severely interact with Ubrelvy |
|
Avoid altogether | Avoid altogether |
| Medications that moderately interact with Ubrelvy |
|
50 mg | Avoid altogether |
| Medications that mildly interact with Ubrelvy |
|
50 mg | 50 mg |
What should you do if you take too much Ubrelvy?
Taking too much Ubrelvy can cause side effects such as nausea, sleepiness and dry mouth. If you think you’ve taken too much Ubrelvy, contact your healthcare team right away. They can provide advice based on your symptoms. If you have symptoms that feel serious or life-threatening after taking too much Ubrelvy, seek emergency care.
How to save on Ubrelvy
There are ways to save on Ubrelvy, which is available as a brand-name medication. GoodRx can help you navigate between patient assistance programs and copay savings cards to save money on your prescription.
Save with patient assistance programs. If you’re uninsured or underinsured, you may be eligible for Ubrelvy’s patient assistance program, which offers the medication free of cost.
Save with a copay savings card. If you have commercial insurance, you may be eligible to receive Ubrelvy for free using a savings card from the manufacturer.
Frequently asked questions
The manufacturer recommends completely avoiding Ubrelvy if you take the following medications:
Ketoconazole
Itraconazole
Clarithromycin
Phenytoin
Rifampin
St. John’s wort
Phenobarbital
Ubrelvy also interacts with many other medications and substances. But most interactions can be managed by adjusting your Ubrelvy dosage.
Small amounts of Ubrelvy may stay in your system for up to 35 hours (about 1.5 days). The half-life of Ubrelvy is about 5 to 7 hours. The “half-life” of a medication is how long it takes for your body to clear half of the medication. As a general rule, it typically takes your body about 4 to 5 half-lives to get rid of most of the medication.
It’s not recommended to take Ubrelvy if you're pregnant. There isn’t enough information available about whether Ubrelvy is safe during pregnancy. Ask your prenatal care team what they recommend you take for migraines while you’re expecting.
Ubrelvy is tolerated well by most people who take it. But nausea is the most common side effect of Ubrelvy. Other common side effects include sleepiness and dry mouth. Serious side effects are rare with Ubrelvy. But some people have experienced allergic reactions from the medication.
The manufacturer recommends completely avoiding Ubrelvy if you take the following medications:
Ketoconazole
Itraconazole
Clarithromycin
Phenytoin
Rifampin
St. John’s wort
Phenobarbital
Ubrelvy also interacts with many other medications and substances. But most interactions can be managed by adjusting your Ubrelvy dosage.
Small amounts of Ubrelvy may stay in your system for up to 35 hours (about 1.5 days). The half-life of Ubrelvy is about 5 to 7 hours. The “half-life” of a medication is how long it takes for your body to clear half of the medication. As a general rule, it typically takes your body about 4 to 5 half-lives to get rid of most of the medication.
It’s not recommended to take Ubrelvy if you're pregnant. There isn’t enough information available about whether Ubrelvy is safe during pregnancy. Ask your prenatal care team what they recommend you take for migraines while you’re expecting.
Ubrelvy is tolerated well by most people who take it. But nausea is the most common side effect of Ubrelvy. Other common side effects include sleepiness and dry mouth. Serious side effects are rare with Ubrelvy. But some people have experienced allergic reactions from the medication.
The bottom line
Ubrelevy (ubrogepant) is an oral medication that can treat migraines. The recommended Ubrelvy dosage is 50 mg or 100 mg taken at the start of migraine symptoms. You may take an additional dose 2 hours later if you’re still having symptoms.
Ubrelvy may require dosage adjustments if you have severe kidney or liver problems. You may also need a different dose if you take other medications that interact with Ubrelvy. So always tell your prescriber and pharmacist about all the medications and supplements you take before starting Ubrelvy.
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References
AbbVie. (2019). Allergan receives U.S. FDA approval for Ubrelvy for the acute treatment of migraine with or without aura in adults.
Allergan. (2021). Ubrelvy- ubrogepant tablet [package insert].
American Migraine Foundation. (n.d.). Migraine signs & symptoms.
Dodick, D. W., et al. (2020). Ubrogepant, an acute treatment for migraine, improved patient‐reported functional disability and satisfaction in 2 single‐attack phase 3 randomized trials, ACHIEVE I and II. Headache.
PubChem. (2025). Ubrogepant. National Library of Medicine.
Tepper, S. J. (2018). History and review of anti-calcitonin gene-related peptide (CGRP) therapies: From translational research to treatment. Headache.
