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Trogarzo Coupon - Trogarzo 2 vials of 200mg/1.33ml carton

Trogarzo

ibalizumab
Used for HIV Treatment
Used for HIV Treatment

Trogarzo (ibalizumab or ibalizumab-uiyk) is an injectable human immunodeficiency virus (HIV) antiretroviral (ARV) medication. It must be given in combination with other ARVs. Trogarzo (ibalizumab) is meant for people who've taken HIV ARVs for a while but haven't had successful treatment due to medication resistance. After the starting dose infusion, Trogarzo (ibalizumab) can be given as a 15-minute infusion or a 30-second injection once every 2 weeks. Some common side effects of this medication include diarrhea, nausea, and dizziness.

Reviewed by:
reviewer
Hope Chang, PharmD, AAHIVP
reviewer
Allison Gourley, PharmD
Last reviewed on February 14, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageAlternativesImagesReferencesPricesMedicare
basics-icon

What is Trogarzo (ibalizumab)?

What is Trogarzo (ibalizumab) used for?

  • HIV (in combination with other HIV medications) when other HIV treatments haven't worked well

How Trogarzo (ibalizumab) works

Trogarzo (ibalizumab) is a monoclonal antibody and HIV attachment inhibitor. It blocks HIV from attaching and entering your CD4 immune cells in order to prevent the virus from spreading.

Drug Facts

Common BrandsTrogarzo
Drug ClassHIV ARV
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
basics-icon

What are the side effects of Trogarzo (ibalizumab)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Labs suggesting kidney problems (10%)
  • Diarrhea (8%)
  • Dizziness (8%)
  • Labs suggesting liver problems (up to 5%)
  • Abnormal blood cell counts (up to 5%)
  • Nausea (5%)
  • Rash (5%)

Other Side Effects

  • Infusion-related reactions
  • Itchy skin

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Infusion-related or allergic reactions: breathing problems, face-swelling, wheezing, chest pain and tightness
  • Immune system changes: fever, difficulty breathing, pain, sudden changes to your health

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Trogarzo (ibalizumab)

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Pros

Good option for people who haven't had success with other HIV medications

Only given once every 2 weeks

Can be administered in a clinic, healthcare provider's office, or at home

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Cons

Injection must be given by a healthcare professional

Not studied in children or older adults

Need to restart treatment with starting dose if you miss a dose by more than 3 days

pharmacist-tips

Pharmacist tips for Trogarzo (ibalizumab)

pharmacist

  • Trogarzo (ibalizumab) is given as an injection into your vein by a healthcare professional. The first infusion will last at least 30 minutes. After that, plan for at least an hour so your care team will monitor you for side effects or reactions. If you don't have a reaction, they'll likely only need to monitor you for 15 minutes after future doses.

    • Trogarzo (ibalizumab) should be given along with other HIV medications. Don't stop other ARVs just because you're starting Trogarzo (ibalizumab) without talking to your provider first.

      • Although Trogarzo (ibalizumab) doesn't have any known interactions with other medications, still tell your provider and pharmacist about all of your other medications that you're taking because they may affect how well your other HIV medications work (or vice versa).

        • If you're interested in receiving home infusions, talk with your healthcare provider. You might be able to have Trogarzo (ibalizumab) infusions done at home if they think it's safe to do so. In this case, you might get the medication shipped directly to your home. Make sure you refrigerate the vials when you receive them. Don't try to mix or dilute the medication yourself, a healthcare professional will do that for you when it's time to give your dose.

          faqs

          Frequently asked questions about Trogarzo (ibalizumab)

          What should I do if I miss a dose of Trogarzo (ibalizumab)?
          Contact your clinic, infusion center, or home health service as soon as you realize you missed a dose of Trogarzo (ibalizumab). If you've missed your dose by 3 days or more, your provider will need to give you a starting dose (Trogarzo (ibalizumab) 2,000 mg given IV), before you can continue on the biweekly maintenance dose.
          How long does it take to receive a dose of Trogarzo (ibalizumab)?
          The first infusion (also known as the starting dose) will take at least 30 minutes. But your provider will likely want to monitor you for an hour after the first infusion to make sure you tolerate the medication well. Depending on how you react to Trogarzo (ibalizumab), your maintenance doses can be given even more quickly, either as a 30-second shot or as a 15 minute infusion. Your provider will still want to monitor you for 15 minutes while after each maintenance dose to make sure you're not having any infusion-related reactions.
          Can I start Trogarzo (ibalizumab) as soon as I'm diagnosed with HIV?
          Trogarzo (ibalizumab) isn't approved for treating HIV in people who are new to ARVs. It's only meant for people who've taken multiple HIV ARVs in the past, have HIV that's resistant to many medications, and aren't having success with their current HIV medications.
          Does Trogarzo (ibalizumab) interact with other medications?
          Researchers haven't done any studies to look at whether Trogarzo (ibalizumab) interacts with other medications. However, based on how this medication works in your body, it's not expected to interact with any other medications. If you have questions about Trogarzo (ibalizumab) and possible medication interactions, talk with your healthcare provider.
          Is it safe to take Trogarzo (ibalizumab) while breastfeeding?
          In general, it's not recommended for people with HIV to breastfeed, due to the risk of passing HIV to your baby.
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          What are the risks and warnings for Trogarzo (ibalizumab)?

          Trogarzo (ibalizumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

          risk-warning

          Infusion-related and allergic reactions

          • Risk factors: History of allergic reaction to Trogarzo (ibalizumab)

            Some people have allergic reactions during their Trogarzo (ibalizumab) infusion. Symptoms include trouble breathing, nausea, facial swelling, wheezing, chest pain or tightness, and hot flashes. Let your care team know if you start to feel any of these symptoms during your infusion. If appropriate, they'll stop your Trogarzo (ibalizumab) infusion and treat your symptoms. If your allergic reaction is very severe, then your provider will need to find alternative treatments for your HIV.

            risk-warning

            Immune reconstitution syndrome

            • Risk factors: Weakened immune system | Current untreated infection

              Although extremely rare, people treated with Trogarzo (ibalizumab) have experienced immune reconstitution inflammatory syndrome(IRIS). This is a reaction that typically occurs during the first 6 months after starting HIV ARV. While the exact reason IRIS happens isn't known, it's thought that as your immune system grows stronger, it starts to fight against infections that you've had in your body before. Most of the time, symptoms of IRIS are mild. Call your provider if you experience fever, difficulty breathing, or sudden changes to your health after starting Trogarzo (ibalizumab).

              risk-warning

              Possible harm to unborn babies

              There's not a lot of research regarding the safety of Trogarzo (ibalizumab) during pregnancy. However, animal studies show that Trogarzo (ibalizumab) given during pregnancy might weaken the immune system of the unborn baby. Let your provider know if you become pregnant or are planning to become pregnant. They can discuss with you the risks and benefits of receiving Trogarzo (ibalizumab) during pregnancy. If you choose to take Trogarzo (ibalizumab) during pregnancy, you're encouraged to register with the Antiretroviral Pregnancy Registry (APR) at 1–800–258–4263 to help researchers better understand the effects of this medication has on pregnancy.

              dosage

              Trogarzo (ibalizumab) dosage forms

              Typical dosing for Trogarzo (ibalizumab)

              Trogarzo (ibalizumab) is usually given in a hospital or another healthcare setting by a healthcare provider.

              • Starting dose: The typical dose is 2,000 mg infused into the veins (IV) once, over 30 minutes.

              • Maintenance dose: Two weeks after your starting dose, your provider will start your maintenance dose. The typical dose is 800 mg infused IV over 15 minutes or given as a fast IV injection over 30 seconds, once every 2 weeks.

              alternatives

              What are alternatives to Trogarzo (ibalizumab)?

              There are a number of medications that your doctor can prescribe in place of Trogarzo (ibalizumab). Compare a few possible alternatives below.
              Trogarzo (ibalizumab)
              Used for:

              • HIV (in combination with other HIV medications) when other HIV treatments haven't worked well

              View Prices
              Rukobia (fostemsavir)
              Used for:

              • Past HIV medications are no longer working, or

              • Can't tolerate side effects of past HIV medications, or

              • Safety concerns about past HIV medication

              $9029.50 Lowest GoodRx priceView Prices
              Maraviroc (Selzentry)
              Used for:
              $396.41 Lowest GoodRx priceView Prices
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              References

              Best studies we found

              Beccari, M.V., et al. (2019). Ibalizumab, a novel monoclonal antibody for the management of multidrug-resistant HIV-1 infection. Antimicrobial Agents and Chemotherapy.

              Centers for Disease Control and Prevention. (2023). Human immunodeficiency virus (HIV).

              Clinical Info HIV.gov. (2023). Entry and fusion inhibitors: Ibalizumab.

              View All References (6)

              HIVinfo.NIH.gov. (2021). Drug resistance.

              Millham, L.R.I., et al. (2021). Clinical and economic impact of ibalizumab for people with multidrug-resistant HIV in the United States. Journal of acquired immune deficiency syndromes: JAIDS.

              Thapa, S., et al. (2023). Immune reconstitution inflammatory syndrome. StatPearls.

              Theratechnologies Inc. (2023). Trogarzo- ibalizumab injection, solution [package insert]. DailyMed.

              Theratechnologies Inc. (2020). Your guide to administering infusions with Trogarzo.

              World Health Organization. (2022). HIV drug resistance.

              GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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