The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Rash
- Itching
Less Common Side Effects
- Stomach pain
- Diarrhea
- Nausea
- Vomiting
- Skin that's sensitive to sunlight (e.g., sunburn)
Trimethoprim serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Allergic reactions: hives; rash; blisters; swelling of the lips, tongue, or face; trouble breathing
- Infectious diarrhea (C. difficile-related diarrhea): foul-smelling diarrhea, fever, nausea, frequent bowel movements (up to 15 times per day)
Source: DailyMed
The following Trimethoprim side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
Rare
Abdominal or stomach pain
black, tarry stools
blistering, peeling, or loosening of skin
changes in skin color
chills
cough or hoarseness
dark urine
dizziness
fever with or without chills
general feeling of tiredness or weakness
headache
joint or muscle pain
light-colored stools
loss of appetite
lower back or side pain
pain, tenderness, or swelling of foot or leg
painful or difficult urination
pale skin
rash
red irritated eyes
red skin lesions, often with a purple center
shortness of breath
sores, ulcers, or white spots in mouth or on lips
swollen or painful glands
tightness in chest
unpleasant breath odor
unusual bleeding or bruising
unusual tiredness or weakness
vomiting of blood
yellow eyes or skin
Incidence not known
Abdominal tenderness
back, leg, or stomach pains
bleeding gums
bleeding under the skin
blindness or vision changes
blood in urine or stools
bluish-colored lips, fingernails, or palms
burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings
burning of face or mouth
clumsiness or unsteadiness
cloudy urine
confusion
continuing ringing or buzzing or other unexplained noise in ears
convulsions
cracks in the skin
decreased frequency or amount of urine
diarrhea, watery and severe, which may also be bloody
difficulty breathing
difficulty swallowing
dizziness or lightheadedness
fainting spells
general body swelling
general feeling of discomfort or illness
hearing loss
increased blood pressure
increased thirst
indigestion
irregular heartbeat
large, flat, blue or purplish patches in the skin
large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
loss of heat from the body
muscle or joint pain
nosebleeds
not able to pass urine
numbness or tingling in hands, feet, or lips
pain or burning while urinating
pains in the stomach, side, or abdomen, possibly radiating to the back
painful knees and ankles
pinpoint red spots on skin
puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
raised red swellings on the skin, the buttocks, legs or ankles
rapid heart rate
red, swollen skin
redness of the white part of the eyes
redness, swelling, or soreness of tongue
shakiness and unsteady walk
soreness of muscles
stiff neck or back
swelling of face, hands, legs, and feet
swelling or inflammation of the mouth
trouble breathing
unsteadiness, trembling, or other problems with muscle control or coordination
unusual weight loss
weakness in hands or feet
weakness or heaviness of legs
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Discouragement
feeling of constant movement of self or surroundings
feeling sad or empty
increased sensitivity of skin to sunlight
irritability
lack of feeling or emotion
loss of interest or pleasure
nervousness
redness or other discoloration of skin
seeing, hearing, or feeling things that are not there
sensation of spinning
severe sunburn
trouble concentrating
trouble sleeping
unable to sleep
uncaring
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
