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Trimethobenzamide Coupon - Trimethobenzamide 300mg capsule

trimethobenzamide

Generic Tigan
Used for Nausea
Used for Nausea

Tigan (trimethobenzamide) is an antiemetic that's used to treat nausea and vomiting from a stomach flu or nausea and vomiting that happens after surgery. This medication is approved for use in adults only. It's available as a generic capsule that's taken by mouth 3 or 4 times a day. It's also available as a brand-only injection, and the dosage depends on how bad your symptoms are and your response to the medication. Potential side effects include diarrhea, drowsiness, and headache.

Last reviewed on January 15, 2024
basics-icon

What is Tigan (trimethobenzamide)?

What is Tigan (trimethobenzamide) used for?

  • Nausea and vomiting related to the stomach flu or surgery

How Tigan (trimethobenzamide) works

Tigan (trimethobenzamide) is an antiemetic. It works in an area of the brain called the vomiting center and blocks the urge to vomit.

Are you looking for information on trimethoprim instead?

Drug Facts

Common BrandsTigan
Drug ClassAntiemetic
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the side effects of Tigan (trimethobenzamide)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Confusion (disorientation)
  • Headache
  • Drowsiness
  • Dizziness
  • Blurred vision
  • Muscle cramps
  • Diarrhea
  • Rash
  • Tremors

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Movement problems: muscle spasms, tremor, restlessness, trouble swallowing or speaking
  • Changes in your brain function: coma, depression, seizures
  • Liver damage: yellowing of your skin or whites of your eyes, belly pain, dark-colored urine

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Abdominal or stomach pain

change in consciousness

chills

clay-colored stools

confusion about identity, place, and time

dark urine

difficulty swallowing

discouragement

dizziness

feeling sad or empty

fever

headache

irritability

itching

lack of appetite

loss of balance control

loss of consciousness

loss of interest or pleasure

mask-like face

nausea

pale skin

rash

seizures

severe spasm where the head and heels are bent backward and the body arched forward

shuffling walk

slowed movements of the arms and legs

slurred speech

sore throat

swelling of the arms, face, legs, lips, tongue, or throat

tic-like (jerky) movements of the head, face, mouth, and neck

trembling and shaking of the fingers and hands

trouble concentrating

trouble sleeping

unpleasant breath odor

unusual bruising or bleeding

unusual tiredness or weakness

vomiting of blood

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Blurred vision

diarrhea

drowsiness

muscle cramps

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Tigan (trimethobenzamide)

thumbs-up

Pros

Capsules are available as a lower-cost generic

Can take with or without food

Starts to work within 10 to 40 minutes

thumbs-down

Cons

Might not be a safe option for people with liver problems

Need to take multiple times a day

Not well-studied in children

pharmacist-tips

Pharmacist tips for Tigan (trimethobenzamide)

pharmacist
  • You can take Tigan (trimethobenzamide) with or without food.

    • Don't give Tigan (trimethobenzamide) to children. It can worsen a condition called Reye's syndrome in children, if that's what's making them nauseous.

      • Tigan (trimethobenzamide) can affect your ability to stay alert, so avoid driving until you know how this medication affects you.

        • Avoid drinking alcohol while you're taking Tigan (trimethobenzamide). This combination can slow down your actions and lower your ability to react, which can be dangerous.

          • Before you start any new medications, talk to your provider or pharmacist first. Medications that make you feel sleepy can interact with Tigan (trimethobenzamide) and lead to excessive drowsiness.

            • If you're pregnant, tell your provider before you take Tigan (trimethobenzamide). There isn't enough information to know whether this medication is safe to take during pregnancy. Your provider can recommend safer options to help with nausea and vomiting during pregnancy.

              faqs

              Frequently asked questions about Tigan (trimethobenzamide)

              Does Tigan (trimethobenzamide) cause QTc prolongation?
              While some antinausea medications are known to cause QTc prolongation, Tigan (trimethobenzamide) doesn't appear to have this effect. QTc prolongation, or "long QT syndrome," is a side effect of some medications. This happens when the time it takes for your heart to reset between beats becomes longer, which can lead to life-threatening heart rhythm problems. It's recommended to discuss the best option to treat your nausea or vomiting with your provider if you have a history of heart problems.
              Is Tigan (trimethobenzamide) still available?
              The brand name Tigan is still available as an intramuscular (IM) injection of trimethobenzamide. But the capsule form of the medication that's taken by mouth is available as a generic version only (under the name trimethobenzamide). Pfizer stopped making brand-name Tigan capsules in 2021, but other manufacturers started making generic versions of them in late 2023.
              Can Tigan (trimethobenzamide) be given IV?
              No. The injectable form of Tigan (trimethobenzamide) is only FDA-approved to be given as an injection into the muscle. It shouldn't be injected into a vein.
              What's the difference between Tigan (trimethobenzamide) and Zofran?
              Tigan (trimethobenzamide) and ondansetron (Zofran) are both antinausea medications, but they have some differences. For one, Tigan (trimethobenzamide) is only FDA-approved to treat nausea and vomiting due to the stomach flu or after surgery. Ondansetron (Zofran) is approved to prevent nausea from certain cancer treatments and after surgery. Another difference is that Tigan (trimethobenzamide) comes as an oral capsule and an injection into the muscle, whereas ondansetron (Zofran) is available as a tablet, orally disintegrating tablet (ODT), oral liquid, and injection into the vein. Tigan (trimethobenzamide) should only be used in adults, but ondansetron (Zofran) is approved for use in children.
              Can you take Zofran and Tigan (trimethobenzamide) together?
              Your provider will decide whether it's safe for you to take Tigan (trimethobenzamide) with ondansetron (Zofran) or any other antinausea medications. There aren't any known interactions between the two, but they might treat nausea and vomiting differently. Ondansetron (Zofran) is thought to work by blocking serotonin in certain areas of the brain that are responsible for. On the other hand, Tigan (trimethobenzamide) hasn't been shown to affect serotonin activity in the brain.
              Can I drink alcohol while I'm taking Tigan (trimethobenzamide)?
              Avoid drinking alcohol with Tigan (trimethobenzamide). Alcohol can make side effects of the medication, like drowsiness, worse. Alcohol can also make your nausea worse.
              Does Tigan (trimethobenzamide) cause constipation?
              Constipation isn't a side effect that's listed in the product information for Tigan (trimethobenzamide). Rather than constipation, some people have reported diarrhea while they took Tigan (trimethobenzamide). Contact your healthcare provider if you notice a change in your bowel movements that's concerning to you while you're taking this medication.
              Is it ok to take Tylenol and Tigan (trimethobenzamide) together?
              Both acetaminophen (Tylenol) and Tigan (trimethobenzamide) have a risk of liver damage. If you have a history of liver problems, ask your provider if this combination is safe for you.
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              What are the risks and warnings for Tigan (trimethobenzamide)?

              Tigan (trimethobenzamide) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Movement problems

              • Risk factors: Taking medications that can cause movement problems

                Tigan (trimethobenzamide) can cause sudden and involuntary muscle spasms, especially in the head and neck. It can also cause Parkinson-like symptoms (e.g., tremor), restlessness, and trouble swallowing or speaking. Call your provider if this happens. Your provider might either spread your doses further apart or have you stop taking the medication altogether.

                risk-warning

                Poor cognition (brain function)

                • Risk factors: Taking Tigan (trimethobenzamide) with sedatives, alcohol, opioids, or anticholinergics

                  Tigan (trimethobenzamide) can cause drowsiness and affect your ability to think clearly or do things safely; don't drive or operate heavy machinery until you know how this medication affects you. Some people who take Tigan (trimethobenzamide) have also experienced depression, confusion, seizures, and even comas. Call your provider right away if you notice a change in your mood or behavior. Also tell your family and caregivers about these risks, so they can contact your provider if you can't get help for yourself.

                  risk-warning

                  Masking other serious health problems

                  The movement and cognition problems that Tigan (trimethobenzamide) can cause as side effects could actually be signs of a more serious, undiagnosed condition. Talk with your provider if you feel you're having changes in your movement, mood, or behavior while you're taking this medication. Your provider will need to examine you and rule out any other health conditions that could be causing those symptoms.

                  risk-warning

                  Liver damage

                  • Risk factors: History of liver problems

                    Tigan (trimethobenzamide) can be harmful to your liver. You might need to get blood tests done beforehand so your provider can make sure you don't have any liver damage before you start this medication. Contact your provider right away if you have yellowing of your skin or whites of your eyes (jaundice), belly pain, or dark-colored urine.

                    dosage

                    Tigan (trimethobenzamide) dosage forms

                    The average cost for 30 capsules of 300mg of Tigan (trimethobenzamide) is $23.58 with a free GoodRx coupon. This is 90.83% off the average retail price of $257.09.
                    capsule
                    Capsule
                    DosageQuantityPrice as low asPrice per unit
                    300mg30 capsules$23.58$0.79

                    Typical dosing for Tigan (trimethobenzamide)

                    The typical dose for the capsules is 300 mg by mouth 3 or 4 times daily.

                    Tigan (trimethobenzamide) is also available as an intramuscular (into the muscle, IM) injection that's administered by a healthcare provider.

                    Your dose might differ if you're 65 years or older or if you have kidney problems.

                    interactions

                    Interactions between Tigan (trimethobenzamide) and other drugs

                    Tigan (trimethobenzamide) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Tigan (trimethobenzamide). Please note that only the generic name of each medication is listed below.

                    Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                    • Bromopride

                    Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                    How much does Tigan (trimethobenzamide) cost?

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                    alternatives

                    What are alternatives to Tigan (trimethobenzamide)?

                    There are a number of medications that your doctor can prescribe in place of Tigan (trimethobenzamide). Compare a few possible alternatives below.
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                    References

                    Best studies we found

                    American Society of Health-System Pharmacists. (2023). Trimethobenzamide capsules.

                    Chartwell RX, LLC. (2023). Trimethobenzamide hydrochloride capsule [package insert]. DailyMed.

                    Griddine, A., et al. (2023). Ondansetron. StatPearls.

                    View All References (5)

                    MedlinePlus. (2024). Secondary parkinsonism.

                    National Institute of Diabetes and Digestive and Kidney Diseases. (2020). Trimethobenzamide. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury.

                    Par Pharmaceutical, Inc. (2023). Tigan- trimethobenzamide hydrochloride injection [package insert]. DailyMed.

                    Smith, H. S., et al. (2012). Dopamine receptor antagonists. Annals of Palliative Medicine.

                    Soghomonyan, S., et al. (2021). PONV management in patients with QTc prolongation on the EKG. Frontiers in Pharmacology.

                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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