The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Note: Side effects were reported by people who injected Remodulin (treprostinil) underneath the skin.
- Pain at the injection site (85%)
- Reactions at the injection site, like redness or irritation (83%)
- Headache (27%)
- Diarrhea (25%)
- Nausea (22%)
- Rash (14%)
- Jaw pain (13%)
- Dizziness or lightheadedness (11%)
- Swelling of the hands or feet (9%)
Less Common Side Effects
- Bleeding
Source: DailyMed
The following Treprostinil side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Accumulation of blood at the site of injection
dry, red, hot, or irritated skin
feeling faint, dizzy, or lightheaded
feeling of warmth or heat
flushing or redness of the skin, especially on the face and neck
headache
redness, hardening of the skin, or rash at the site of injection
swelling
Less common
Blurred vision
confusion
dizziness, faintness, lightheadedness when getting up suddenly from a lying or sitting position
sudden sweating
unusual tiredness or weakness
Incidence not known
Black, tarry stools
bleeding gums
blood in the urine or stools
bone pain
changes in skin color, pain, tenderness, or swelling of the foot or leg
decreased urine output
difficult or labored breathing
dilated neck veins
extreme tiredness or weakness
irregular breathing
irregular heartbeat
itching, pain, redness, swelling, or tenderness on the skin
paleness of the skin
pinpoint red spots on the skin
tightness in the chest
troubled breathing
unusual bleeding or bruising
Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
Loss of consciousness
seizure
unusual tiredness or weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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