The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Involuntary movements (dyskinesia, 42%)
- Nausea (30%)
- Sleep problems (24%)
- Excessive dreaming (21%)
- Muscle contractions and cramps (17—19%)
- Loss of appetite (19%)
- Sleepiness (18%)
- Low blood pressure (17%)
- Diarrhea (16%)
- Dizziness (13%)
- Confusion (11%)
- Headache (10%)
Less Common Side Effects
- Hallucinations
- Tiredness
- Fainting
- Stomach pain and upset stomach
- Vomiting
- Constipation
- Dry mouth
- Falling
- More sweating
- Bladder infection
- Common cold or flu
Tolcapone serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious liver damage: yellowing of the skin or eyes, pale colored stools, loss of appetite, persistent nausea, tiredness, low energy, dark urine, itchiness, tenderness in the upper right side of your stomach
- Severe muscle damage (rhabdomyolysis): muscle aches, soreness, cramping, dark-colored urine
- Symptoms similar to neuroleptic malignant syndrome (NMS): very high fevers, irregular pulse, sweating, muscle stiffness, confusion, changes in blood pressure
Source: DailyMed
The following Tolcapone side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Check with your doctor as soon as possible if any of the following side effects occur:
More common
Abdominal pain
dizziness
dizziness or lightheadedness when getting up from a lying or sitting position
drowsiness
fainting
hallucinations (seeing, hearing, or feeling things that are not there)
headache
nasal congestion (stuffy nose)
trouble in sleeping
twitching, twisting, or other unusual body movements
vomiting
Less common
Absence of or decrease in body movement
blood in urine
chills
confusion
falling
general feeling of discomfort or illness
hyperactivity
loss of balance control
troubled breathing
Rare
Agitation
bloody or cloudy urine
burning of feet
burning, prickling, or tingling sensations
chest discomfort
difficult or painful urination
difficulty in thinking or concentrating
frequent urge to urinate
irritability
joint pain, redness, or swelling
muscle cramps
neck pain
stiffness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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