Type your drug name (like Atorvastatin, Sildenafil, etc)
LIDOCAINE; TETRACAINE causes loss of feeling in the skin and surrounding tissues. It is used to numb the skin before a procedure. Compare local anesthetics.
Prescription Settings
10 patches
10 patches

Synera Side Effects

What should I watch for?

After use of this medicine, you will be numb for some time. Be careful to avoid injury while the area is numb and you are not aware of pain. Do not scratch, rub, or expose the skin to hot or cold while you are numb.

Do not touch this medicine to the eye. It may cause irritation and injury. If this medicine does touch the eye, wash the eye out with water or saline for eyes. Then protect the eye until feeling returns.

Do not cut the patch or remove the top cover as this could cause the patch to overheat and burn the skin. Do not cover the holes on the top side of the patch as this could cause the patch not to heat.

If you are going to have a magnetic resonance imaging (MRI) procedure, tell your MRI technician if you have this patch on your body. It must be removed before a MRI.


Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Flushing or redness of the skin


unusually warm skin

Less common

Blistering, burning, crusting, dryness, or flaking of the skin

change in the color of treated skin

itching, scaling, severe redness, soreness, or swelling of the skin



Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

cough or hoarseness

fainting or loss of consciousness

fast or irregular breathing

fever or chills

hives or welts

lower back or side pain

painful or difficult urination

swelling of the eyes or eyelids

tightness in the chest or wheezing

trouble with breathing

Incidence not known

Blurred vision

chest pain or discomfort

cold, clammy, or pale skin


difficulty with breathing

difficulty with swallowing


dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

fast, slow, or irregular heartbeat

feelings of coldness, heat, or numbness

irregular, fast or slow, or shallow breathing

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

no breathing

noisy breathing

pale or blue lips, fingernails, or skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


shakiness in the legs, arms, hands, or feet

shortness of breath

slow heart rate


trembling or shaking of the hands or feet



unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Change in consciousness

fast, pounding, or irregular heartbeat or pulse

no blood pressure or pulse

stopping of heart

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:




sleepiness or unusual drowsiness


Incidence not known

Continuing ringing or buzzing or other unexplained noise in the ears


double vision


false or unusual sense of well-being


hearing loss


Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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