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Symproic (naldemedine) is used to treat constipation caused by opioids (pain medicine). Tell your health care professional if you stop taking your opioid pain medicine. Symproic is less popular than comparable drugs. There are currently no generic alternatives for Symproic.
GoodRx has partnered with InsideRx and BDSI to reduce the price for this prescription. Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost. Symproic is covered by some Medicare and insurance plans.
Get Symproic for as low as $465.70, which is 20% off the average retail price of $582.85 for the most common version, by using a GoodRx coupon.

| Dosage | Quantity | Retail price | GoodRx price |
|---|
| 0.2mg | 30 tablets | $579.81 | $490.20 |
GoodRx coupon prices last updated on 05/01/26.