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Sulfadiazine

Sulfadiazine Side Effects

Kristianne Hannemann, PharmDConnie Zheng, PharmD
Reviewed by Kristianne Hannemann, PharmD, Connie Zheng, PharmD
Last reviewed on April 21, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Stomach pain
  • Loss of appetite
  • Headache
  • Dizziness

Less Common Side Effects

  • Feeling unsteady on your feet
  • Tingling in the hands and feet
  • Trouble sleeping
  • Ringing in your ears
  • Kidney stones

Sulfadiazine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe allergic reaction: hives, trouble breathing, swelling of the face, lips, tongue, or throat
  • Severe skin reaction: rash, peeling skin, blisters, red skin
  • Seizures
  • Low blood cell counts: fever, chills, feeling tired, paleness, bleeding
  • Kidney problems: producing less or no urine, dark urine
  • Liver problems: stomach pain, yellowing of the skin or whites of the eyes, clay-colored stool

Source: DailyMed

The following Sulfadiazine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Anxiety

blurred vision

changes in menstrual periods

chills

cold sweats

coma

confusion

cool, pale skin

decreased sexual ability in males

depression

dizziness

dry, puffy skin

fast heartbeat

feeling cold

headache

increased hunger

nausea

nervousness

nightmares

seizures

shakiness

slurred speech

swelling of front part of the neck

unusual tiredness or weakness

weight gain

Incidence not known

Abdominal or stomach pain

back, leg, or stomach pains

black, tarry stools

bleeding gums

bleeding under the skin

blindness or vision changes

blistering, peeling, or loosening of the skin

bloating

blood in the urine or stools

bluish-colored lips, fingernails, or palms

burning of the face or mouth

burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings

chest pain

cloudy urine

clumsiness or unsteadiness

constipation

continuing ringing or buzzing or other unexplained noise in the ears

cough or hoarseness

cracks in the skin

darkened urine

decrease in the amount of urine

diarrhea

difficulty with breathing

difficulty with moving

dizziness or lightheadedness

feeling of discomfort

fever with or without chills

general body swelling

general feeling of tiredness or weakness

headache

hearing loss

indigestion

itching

joint or muscle pain

light-colored stools

loss of appetite and weight

loss of heat from the body

lower back or side pain

muscle pain or stiffness

nosebleeds

not able to pass urine

pain or burning while urinating

painful or difficult urination

pains in the stomach, side, or abdomen, possibly radiating to the back

pale skin

pinpoint red or purple spots on the skin

rapid heart rate

rash

red skin lesions, often with a purple center

red, irritated eyes

red, swollen skin

redness of the white part of the eyes

scaly skin

seeing, hearing, or feeling things that are not there

seizures

shakiness and unsteady walk

shortness of breath

sore throat

soreness of the muscles

sores, ulcers, or white spots on the lips or in the mouth

sudden decrease in amount of urine

swelling around the eyes

swelling of the face, hands, legs, and feet

swelling or inflammation of the mouth

swollen lymph glands

swollen or painful glands

tightness in the chest

unsteadiness, trembling, or other problems with muscle control or coordination

unusual bleeding or bruising

upper right abdominal pain

vision changes

vomiting

weakness in the hands or feet

wheezing

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Feeling of constant movement of self or surroundings

hives or welts

sensation of spinning

sleeplessness

trouble with sleeping

unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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