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Itraconazole

Itraconazole Side Effects

Robert Chad Hakim, PharmD, BCCCPKristianne Hannemann, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Kristianne Hannemann, PharmD
Last reviewed on January 13, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Nausea (11%)
  • Diarrhea (11%)
  • Vomiting (7%)
  • Fever (7%)
  • Stomach pain (6%)

Less Common Side Effects

  • Rash
  • Constipation
  • Tiredness
  • Coughing
  • Dizziness
  • Sweating
  • Headache
  • Trouble breathing
  • Chest pain

Itraconazole serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Congestive heart failure (CHF): trouble breathing, swelling in the arms and legs, sudden weight gain, tiredness, dizziness, lightheadedness, feeling your heart beat very fast
  • Abnormal heart rhythm: dizziness, feeling faint, lightheaded, feeling your heart beating fast
  • Liver damage: nausea, vomiting, unusual tiredness, yellowing of the skin or whites of the eyes (jaundice), dark-colored urine, pale-colored stools
  • Hearing loss: muffled hearing, difficulty understanding speech
When do Itraconazole possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Hearing loss
Liver damage
Seek immediate medical care if you experience this side effect.

Source: DailyMed

The following Itraconazole side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Decreased urine output

dry mouth

fever

increased thirst

irregular heartbeat

loss of appetite

mood changes

muscle pain or cramps

nausea

numbness or tingling in the hands, feet, or lips

seizures

trouble breathing

unusual tiredness or weakness

vomiting

Less common

Blurred vision

chest pain

chills

clay-colored stools

cloudy urine

cold sweats

confusion

cough

dark urine

decrease in urine-concentrating ability

diarrhea

dizziness

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

drowsiness

feeling unusually cold

headache

itching, skin rash

light-colored stools

mental changes

muscle cramps in the hands, arms, feet, legs, or face

muscle spasms (tetany) or twitching

nervousness

noisy, rattling breathing

numbness and tingling around the mouth or fingertips

pounding in the ears

shivering

slow, fast, or pounding heartbeat or pulse

sneezing

sore throat

stomach cramps or pain

sweating

swelling of the fingers, hands, feet, or lower legs

tightness in the chest

trembling

troubled breathing at rest

unpleasant breath odor

vomiting of blood

weight gain

yellow eyes or skin

Rare

Black, tarry stools

bleeding gums

blistering, peeling, or loosening of the skin

bloating or swelling of the face, arms, hands, lower legs, or feet

blood in the urine or stools

blue lips and fingernails

burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings

continuing ringing or buzzing or other unexplained noise in the ears

coughing that sometimes produces a pink frothy sputum

cracks in the skin

decreased appetite

difficulty with swallowing

dilated neck veins

disturbed color perception

double vision

extreme tiredness or weakness

fast or irregular breathing

feeling of discomfort

general feeling of tiredness or weakness

halos around lights

hearing loss

hives or welts

inflammation of the joints

joint pain

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals

loss of heat from the body

loss of vision

lower back or side pain

night blindness

overbright appearance of lights

painful or difficult urination

pale skin

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rapid weight gain

red skin lesions, often with a purple center

red, irritated eyes

red, swollen skin

scaly skin

sores, ulcers, or white spots on the lips or in the mouth

stomach pain, continuing

stomach tenderness

swollen lymph glands

tunnel vision

unsteadiness or awkwardness

unusual bleeding or bruising

unusual weight gain or loss

upper right abdominal or stomach pain

weakness in the arms, hands, legs, or feet

Incidence not known

Bloating

constipation

difficult, fast, noisy breathing

indigestion

loss of bladder control

pains in the stomach, side, or abdomen, possibly radiating to the back

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Decreased interest in sexual intercourse

difficulty having a bowel movement

difficulty with moving

discouragement

feeling of constant movement of self or surroundings

feeling sad or empty

inability to have or keep an erection

irritability

loss in sexual ability, desire, drive, or performance

loss of interest or pleasure

muscle aching or stiffness

pain or tenderness around the eyes and cheekbones

passing of gas

sensation of spinning

sleepiness or unusual drowsiness

soreness of the skin

stomach fullness or discomfort

stuffy or runny nose

trouble concentrating

trouble sleeping

Rare

Belching

change in taste

hair loss or thinning of the hair

heartburn

increased need to urinate

increased sensitivity of the eyes or skin to sunlight

loss of taste

menstrual changes

passing urine more often

redness or other discoloration of the skin

severe sunburn

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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