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Voriconazole

Voriconazole Side Effects

Robert Chad Hakim, PharmD, BCCCPKristianne Hannemann, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Kristianne Hannemann, PharmD
Last reviewed on June 3, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Adults:

  • Vision changes (19%)
  • Fever (6%)
  • Nausea (5%)
  • Rash (5%)

Children:

  • Vision changes (26%)
  • Fever (25%)
  • Vomiting (20%)
  • Nose bleeds (16%)
  • Nausea (13%)
  • Rash (13%)
  • Stomach pain (12%)
  • Low blood potassium levels (11%)
  • Diarrhea (11%)
  • High blood pressure (11%)
  • Cough (10%)
  • Low platelet count (10%)
  • Headache (10%)

Less Common Side Effects

Adults

  • Vomiting
  • Chills
  • Headache
  • High liver enzymes
  • Fast heart rate
  • Hallucinations (seeing or hearing things that aren't real)

Children

  • Low blood pressure
  • High blood sugar
  • Swelling in the arms and legs
  • Fast heart rate
  • Dizziness
  • Hallucinations (seeing or hearing things that aren't real)
  • Shortness of breath
  • Low blood calcium levels
  • Low magnesium levels
  • Constipation
  • High liver enzymes

Voriconazole serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Liver damage: nausea, vomiting, feeling tired, stomach pain, yellowing of your skin or whites of your eye (jaundice), dark-colored urine, pale-colored stool
  • Abnormal heart rhythm (QT prolongation): chest pounding, short of breath, chest pain, feeling faint or lightheaded
  • Serious allergic and skin reactions: hives, rash, blisters, swelling of the lips or tongue, difficulty breathing, skin reddening, skin scaling, skin itching
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Source: DailyMed

The following Voriconazole side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Black, tarry stools

blistering, peeling, loosening of the skin

chest pain

chills

cough

diarrhea

difficulty seeing at night

fever

increased sensitivity of the eyes to sunlight

itching, rash

joint or muscle pain

painful or difficult urination

red irritated eyes

red skin lesions, often with a purple center

sore throat

sores, ulcers, or white spots on the lips or in the mouth

swollen glands

trouble breathing

unusual bleeding or bruising

unusual tiredness or weakness

vision changes

Less common

Bloating or swelling of the face, arms, hands, lower legs, or feet

blurred vision

chills

clay-colored stools

confusion

dark urine

decreased urine

dizziness

dry mouth

faintness or lightheadedness when getting up suddenly from a lying or sitting position

feeling of warmth

increased thirst

irregular or pounding heartbeat

loss of appetite

muscle pain or cramps

muscle spasms or twitching

nausea

nervousness

numbness or tingling in the hands, feet, or lips

pounding in the ears

rapid weight gain

rash with flat lesions or small raised lesions on the skin

redness of the face, neck, arms, and occasionally, the upper chest

seizures

stomach pain

slow or fast heartbeat

sweating

trembling

unpleasant breath odor

vomiting of blood

yellow eyes or skin

Rare

Agitation

blistering, peeling, or loosening of the skin

hostility or anger

increased sensitivity of the skin to sunlight

irritability

redness or other discoloration of the skin

seeing things that are not there

severe sunburn

Incidence not known

Backache

blindness

blue-yellow color blindness

bone pain

darkening of the skin

decreased vision

diarrhea

facial hair growth in females

fainting

fractures

full or round face, neck, or trunk

increased urination

irritability

loss of sexual desire or ability

menstrual irregularities

mental depression

muscle wasting

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Headache

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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