Key takeaways:
Soliqua 100/33 is an injectable Type 2 diabetes medication. It combines a long-acting insulin (insulin glargine) and a glucagon-like peptide-1 (GLP-1) receptor agonist (lixisenatide) in a single pen.
Most insurance plans cover Soliqua. But restrictions like prior authorization or step therapy may be required, especially for Medicaid plans.
Without insurance, 5 Soliqua pens (1 carton) can cost an average of $1085.33. GoodRx coupons, manufacturer copay cards, and patient assistance programs can help reduce your out-of-pocket cost.
Save on related medications
Soliqua 100/33 is a combination injection that’s used to treat Type 2 diabetes. It contains insulin glargine, a long-acting insulin, with lixisenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, into 1 daily injection.
If you need both insulin and a GLP-1 medication, Soliqua can be a convenient option. But if you don’t have insurance, it’s helpful to know how much Soliqua costs and how you can lower your out-of-pocket expenses.
How much does Soliqua cost without insurance?
Without insurance or discounts, 5 Soliqua pens (1 carton) can cost an average of $1085.33. Each Soliqua pen contains 300 units of insulin glargine and 100 mcg of lixisenatide. Soliqua is injected once a day, with a maximum daily dosage of 60 units insulin / 20 mcg lixisenatide. How long each carton lasts will depend on your dosage.
Soliqua is available as a brand-name medication. It doesn’t have a generic alternative.
Which factors affect the cost of Soliqua?
Several factors can affect how much you pay for Soliqua, including:
Insurance coverage: If you have insurance, your out-of-pocket cost depends on your plan’s formulary (list of covered medications), medication tier, and whether you’ve met your deductible. Your copay or coinsurance will also affect the final price.
Dose and quantity: Higher daily doses of Soliqua may require more frequent refills, which can increase how much you pay each month. But filling a 90-day supply (rather than monthly) may reduce your average monthly cost.
Pharmacy pricing: The price of Soliqua can vary from pharmacy to pharmacy. So comparing options with price comparison tools like GoodRx may help you find the lowest price.
Discounts: If you’re eligible, a manufacturer copay savings card, rebate, or patient assistance program could help you pay less for Soliqua. Free GoodRx coupons can also help you save money on your prescription.
Does insurance cover Soliqua?
Most insurance plans cover Soliqua. This includes commercial insurance, Affordable Care Act (ACA) marketplace plans, and government-funded plans like Medicare and Medicaid.
Most Medicaid and some ACA and commercial plans require prior authorization before Soliqua is covered. In this case, your prescriber needs to provide documentation showing why Soliqua is the best option for you. Step therapy may also be required, meaning that you may need to try other medications first. These requirements are rare with Medicare plans.
How different insurance plans cover Soliqua
The table below breaks down the percentage of enrollees who have coverage for Soliqua by insurance type. It also shows the likelihood of having prior authorization and step therapy requirements.
Insurance type | Enrollees covered for Soliqua | Enrollees required to get prior authorization | Enrollees required to do step therapy |
93.1% | 38.3% | 48.5% | |
Commercial plans (excluding ACA plans) | 93.5% | 14.1% | 19.8% |
Medicare (Medicare Advantage and Part D plans) | 88.3% | 0% | 0.7% |
Medicaid, including state-run and managed care plans | 99.9% | 87.4% | 61.1% |
Source: Managed Markets Insight & Technology, LLC™, as of January 10, 2026 (See methodology below.)
If your insurance doesn’t cover Soliqua, try these options:
Explore manufacturer-sponsored programs. If you have commercial insurance, you may qualify for a manufacturer copay savings card to lower the monthly cost. A patient assistance program is also available, depending on your insurance status and household income.
Request a coverage exception. Your prescriber can submit documentation to your insurance plan explaining why Soliqua is medically necessary for you. If the request isn’t approved, you have the right to file an appeal.
Ask your prescriber about alternatives. In some cases, using insulin and a GLP-1 medication separately may be less expensive. Another combination option, Xultophy (insulin degludec / liraglutide), may also be worth discussing depending on your insurance coverage and medical needs.
Compare plans during open enrollment. If you can switch plans, compare formularies to find one that offers better coverage for Soliqua and other medications you take.
Ways to save on Soliqua
Without insurance, Soliqua can cost over $1,000 per month. But there are ways to help make your prescription more affordable — or even get it for free. Explore these six savings strategies.
1. Use a GoodRx coupon
GoodRx can help you save on Soliqua. With a free GoodRx coupon, the price of 5 Soliqua pens is as low as $901.41 at certain pharmacies.
Search for Soliqua on the GoodRx website or app, select the pharmacy of your choice, and present the coupon at the pharmacy. To avoid delays when picking up your prescription, tell the pharmacy in advance that you’re using a GoodRx coupon.
2. See if you qualify for a copay savings card
If you have commercial insurance, you may qualify for a manufacturer copay savings card that lowers your monthly cost. With the card, you could pay as little as $35 for a 30-day supply for Soliqua (up to 2 cartons) if your plan covers the medication. There is a maximum savings limit of up to $365 per carton for each 30-day supply. If Soliqua isn’t covered, you could pay as little as $99 per carton.
To be eligible, you must:
Have commercial insurance
Have a valid prescription for Soliqua
Be at least 18 years old
Be a resident of the U.S. or a U.S. territory
Not have government-funded insurance (such as Medicare or Medicaid)
You can see if you’re eligible for the card and enroll online. Call the Soliqua Savings Program at 1-833-950-1304 if you have questions or need assistance.
3. Check if you’re eligible for a patient assistance program
Soliqua’s manufacturer also offers a patient assistance program that provides the medication at no charge. You may be eligible for the program if you:
Are a resident of the U.S. or a U.S. territory
Are uninsured, have a commercial insurance or Medicaid plan that doesn’t cover Soliqua, or have access to Soliqua through Medicare Part D or Medicare Part B without supplemental coverage
Meet household income requirements
To enroll, download the application and fill in the patient-specific sections. Then ask your prescriber to fill out the rest and submit it on your behalf. If you have questions or need assistance, call 1-888-847-4877.
4. Ask about 90-day supplies
Filling a 90-day supply of Soliqua instead of a 30-day supply may lower your cost per month. It can also reduce pharmacy visits and help ensure you don’t miss doses. If Soliqua has been working well, you can ask your prescriber and insurance plan if this is an option for you.
5. Tap into your HSA, FSA, or HRA
If you have a health savings account (HSA), a flexible spending account (FSA), or a health reimbursement arrangement (HRA), you can use those pretax funds to pay for Soliqua. Keep in mind that FSA funds may expire at the end of your plan year, while HSA funds roll over annually. Be sure to keep your receipts to show proof of eligible expenses.
6. Ask about alternatives
If Soliqua is still too expensive, ask your prescriber about other options. In some cases, using insulin and a GLP-1 medication separately may be more affordable. For example, many insulin products are available for no more than $35 per month, regardless of insurance status. And there are a variety of discounts available for GLP-1 medications.
Another combination product, Xultophy, may be worth discussing if it has better coverage through your insurance.
Good to know: Lixisenatide was available on its own as Adlyxin, but this product has been discontinued. There are many other GLP-1s available if you need to use one separately.
The bottom line
Soliqua (insulin glargine / lixisenatide) is a combination injection that’s used to treat Type 2 diabetes. Without insurance, 5 Soliqua pens (1 carton) can cost an average of $1085.33.
Most insurance plans cover Soliqua. But prior authorization or step therapy may be required, especially for Medicaid plans. These requirements are rare with Medicare plans.
GoodRx coupons, manufacturer copay savings cards, and patient assistance programs can help reduce the cost of Soliqua. Your healthcare team can help you navigate your savings options.
Why trust our experts?
Methodology
We obtained national prescription coverage data for each medication from Managed Markets Insight & Technology (MMIT). The data reflects health insurance coverage as of January 10, 2026.
We calculated the percentage of enrollees in plans that cover each medication by dividing the number of enrollees covered for the medication within a specific insurance channel (e.g., ACA, Medicare, Medicaid) by the total number of enrollees in all plans within that channel.
We determined the percentage of enrollees in plans with a prior authorization requirement by calculating the proportion of enrollees in plans that required prior authorization for the medication within each channel.
Finally, we measured the percentage of enrollees in plans with a step therapy requirement by calculating the proportion of enrollees in plans that imposed step therapy requirements for the medication in each channel.
These estimates, derived from national MMIT coverage data, provide insight into health insurance coverage for each medication. They take into account restrictions such as prior authorization, step therapy, and quantity limits. The percentages are expressed relative to the total number of enrollees covered by various insurance channels, including ACA plans, commercial (excluding ACA) plans, Medicare, and Medicaid (both state-run and managed care plans).
References
Medicaid.gov. (n.d.). Managed care. Centers for Medicare & Medicaid Services.
Patient Connection. (n.d.). Patient assistance connection. Sanofi.
Patient Connection. (n.d.). Soliqua 100/33 savings and support options. Sanofi.
Patient Connection. (n.d.). Welcome to Sanofi Patient Connection. Sanofi.
Patient Connection. (2025). Connecting patients to medication and resources. Sanofi.
Sanofi-Aventis U.S. (2026). Soliqua 100/33- insulin glargine and lixisenatide injection, solution. DailyMed.
Soliqua 100/33. (n.d.). Pay as little as $35 for a 30-day supply with the co-pay card. Sanofi.
Soliqua 100/33. (2024). How much should I expect to pay for Soliqua 100/33? Sanofi.
