The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Change in urine color (30%)
- Low blood cell count (up to 25%)
- Rash (11%)
- Higher liver enzymes (7-9%)
- Nausea (6%)
Less Common Side Effects
- Stomach pain
- Fever
- Headache
- Low appetite
- Diarrhea
- Upset stomach
- Excessive gas
- Vomiting
- Muscle pain
- Change in taste
Rifabutin serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Severe skin or allergic reaction: fever, body aches, rash, swelling of your lips or tongue, trouble breathing, blistering or peeling skin
- Infectious diarrhea: fever, tiredness, stomach pain, watery diarrhea, loose stools multiple times a day
Source: DailyMed
The following Rifabutin side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common
Black, tarry stools
chills
indigestion
itching or skin rash
loss of appetite
loss of strength or energy
painful or difficult urination
ulcers, sores, or white spots in the mouth
unusual bleeding or bruising
unusual tiredness or weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

