Rapivab
Rapivab (peramivir) is an antiviral medication that's used to treat the flu in people 6 months and older. It's given as a one-time intravenous (IV) infusion by a trained healthcare professional, typically in a hospital setting. It should only be used within 2 days of when symptoms started. Diarrhea is the most common side effect of this medication.
What is Rapivab (peramivir)?
What is Rapivab (peramivir) used for?
- Flu treatment in people 6 months and older
How Rapivab (peramivir) works
Rapivab (peramivir) is a neuraminidase inhibitor. It's an antiviral medication that stops a protein in the influenza (flu) virus called neuraminidase. When this protein is blocked, the virus can't spread throughout your body.
Drug facts
Side effects of Rapivab (peramivir)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Diarrhea (8%)
Less Common Side Effects
- Constipation
- Difficulty falling asleep
Rapivab (peramivir) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reactions: rash, hives, difficulty breathing, swelling of the face, lips, mouth, or throat
- Serious skin reactions: painful rash, blisters, peeling skin
- Abnormal thoughts and behaviors: hallucinations, feeling confused and disoriented
The following Rapivab (peramivir) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Redness, blistering, peeling, or loosening of the skin, including inside the mouth
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Constipation
- Diarrhea
- Trouble sleeping
- Vomiting
Pros and cons of Rapivab (peramivir)
Pros
- Single dose
- Can shorten the amount of time you have flu symptoms by 1 day
- Possible option for people with kidney problems
Cons
- Infused intravenously over 15 to 30 minutes
- Can't prevent the flu, unlike some other neuraminidase inhibitors, such as Tamiflu (oseltamivir)
- Needs to be taken within 2 days of flu symptoms
Pharmacist tips for Rapivab (peramivir)
- If you choose to get the live intranasal vaccine after a course of Rapivab (peramivir), wait at least 2 days after the end of your infusion.
- You need to receive Rapivab (peramivir) within 48 hours of having flu symptoms. Otherwise, it might not work as well.
- A Rapivab (peramivir) infusion takes about 15 to 30 minutes, so you might want to bring something to listen to or read to pass the time.
- If you're on hemodialysis, make sure your prescriber knows your dialysis schedule. Rapivab (peramivir) should be given after dialysis.
- Rapivab (peramivir) is only approved to treat the flu. To protect yourself from catching the flu, it's important to get a flu shot every year.
- Rapivab (peramivir) might cause the live intranasal vaccine (FluMist) to not work well if it has been less than 2 weeks since your vaccination. If you've received the live flu vaccine, let your healthcare team know before your Rapivab (peramivir) infusion.
Common questions about Rapivab (peramivir)
No, Rapivab (peramivir) is given as an intravenous (IV) infusion. It must be given by a trained healthcare professional.
Unlike some other neuraminidase inhibitors, such as Tamiflu (oseltamivir), Rapivab (peramivir) is only FDA-approved to treat the flu. It's prescribed to help people recover faster by stopping the flu virus from spreading in the body. This medication is given as a one-time IV infusion and works best if started within 2 days of symptoms. If you want to prevent the flu, some ways to protect yourself include getting a flu shot, washing your hands often, and if possible, avoiding close contact with those who are sick with the flu. Talk with your healthcare team if you have more questions about flu prevention.
It can. Some people reported constipation as a side effect during clinical studies. To minimize this side effect, drink enough fluids to stay hydrated and eat foods high in fiber to prevent constipation. If you become constipated, ask your healthcare professional about appropriate treatment options.
Although not common, Rapivab (peramivir) can cause a skin rash as a side effect. In rare cases, it might trigger serious skin reactions like Stevens-Johnson syndrome (SJS), which can cause fever, chills, muscle aches, rash that spreads, and blistering and peeling skin. If you have SJS, you need treatment right away because this condition can become life-threatening. Tell your prescriber if you notice a rash after taking this medication and they can let you know about next steps.
More research is needed to understand whether Rapivab (peramivir) is safe to receive during pregnancy. If you catch the flu while pregnant, let your healthcare team know right away and they can talk with you about the risks and benefits of different treatment options. If you need an antiviral medication and are able to take medications by mouth, your care team might recommend Tamiflu (oseltamivir) instead because it's the first-choice antiviral medication to treat flu during pregnancy.
No, Rapivab (peramivir) is an antiviral and only works against the influenza virus. Antibiotics are used to fight bacterial infections.
How to save using GoodRx
Risks and warnings for Rapivab (peramivir)
Rapivab (peramivir) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Allergic and serious skin reactions
- Risk factors: Prior severe allergic reaction to Rapivab (peramivir)
It's rare, but some people have had serious allergic and skin reactions to Rapivab (peramivir). Symptoms of such reactions can include hives, painful rash and blisters all over the body, difficulty breathing, and swelling of the face, lips, mouth, or throat. If this happens to you, the infusion will be stopped, and your care team will treat your reaction depending on the symptoms. This allergy should be added to your medication allergy list, and you shouldn't receive Rapivab (peramivir) again in the future. Get medical help if you notice any of the symptoms listed above once you get home, since allergic reactions can sometimes happen later.
Unusual thoughts and behaviors
- Risk factors: Children
There have been reports of people (mostly children) having unusual thoughts and behaviors that can lead to harm to self or others after starting Rapivab (peramivir). The flu itself can also cause people to have unusual behaviors and hallucinations. It's difficult to know if these symptoms are caused by the medication or the flu. Look out for signs of unusual thoughts or behaviors and tell your prescriber if this happens to you.
Not for treating bacterial infections
Rapivab (peramivir) only treats influenza viruses. It won't prevent or treat bacterial infections. Sometimes, a person with a bacterial infection might have flu-like symptoms. In some cases, a person might have both the flu and an underlying bacterial infection. Your prescriber should examine you thoroughly and treat you with antibiotics if you have a bacterial infection.
Rapivab (peramivir) dosage
Typical dosage for Rapivab (peramivir)
Rapivab (peramivir) is given as an infusion through the veins in a hospital setting by a healthcare professional.
- Adults and children age 13 or older: The typical dose is 600 mg infused over 15 to 30 minutes as a single dose.
- Children age 6 months to 12 years old: Your child's pediatrician will determine the dose based on your child's body weight. The typical dose is 12 mg/kg (maximum of 600 mg) infused over 15 to 30 minutes as a single dose.
Your dose might be different if you have kidney problems.
What are alternatives to Rapivab (peramivir)?
