Iron/folic acid is a combination dietary supplement. It's usually used for people who have low levels of iron and folic acid to help prevent problems like anemia. Providers might also recommend it as a prenatal vitamin during pregnancy for a baby's development and growth. It's taken by mouth, usually once to three times a day, depending on the brand name (e.g. Bentivite, ProFerrin Forte). Some potential side effects of iron/folic acid include constipation, nausea, and stomach upset.
Dietary supplement
Iron/folic acid is a combination of two medications:
Iron is required for your body to make hemoglobin, a protein in your blood that carries oxygen to the rest of your body.
Folic acid is important in helping your tissues and cells grow, as well as helping your body make genetic material (DNA) and new red blood cells.
Source:Â DailyMed
Works well to treat anemia, low iron, and low folic acid levels
Convenient to take two medications in a single pill
Some iron/folic acids are formulated specifically for pregnant people
Difficult to customize the dose since each pill contains two medications
Food can affect how well iron/folic acid is absorbed in your body
Take iron/folic acid on an empty stomach because your body absorbs iron better this way. But if iron/folic acid is hurting your stomach, taking it with a small amount of food can help. Just make sure to be consistent with how you take the medication and tell your provider if you're taking it with food or not.
Make sure to tell your provider and pharmacist about all the medications you're taking before starting iron/folic acid. Certain medications, such as levothyroxine (Synthroid) and tetracyclines, interact with the iron in iron/folic acid and affect how it works. Don't start any new medications while taking iron/folic acid without talking to your provider or pharmacist first.
Check the labels of any other vitamins (including multivitamins) and supplements you're taking. Don't take additional iron or folic acid to what's prescribed by your provider. Doing so can lead to side effects from iron or folic acid, such as upset stomach, nausea, and constipation.
Make sure to eat a healthy and balanced diet that contains enough folic acid (or folate) and iron. Depending on your iron and folic acid levels and why you're taking iron/folic acid, it's possible you might be able to stop taking iron/folic acid if your nutrient levels are enough with diet alone.
Stomach-related side effects (e.g., nausea, vomiting, diarrhea, constipation, passing gas) are the most common with iron/folic acid. If these symptoms bother you a lot, talk to your provider because you might need to be switched to a different iron supplement.
Iron/folic acid can cause your stool to be discolored, which is a common side effect of iron supplements. Don't be alarmed if you see your stool turn a tarry-black color.
Keep iron/folic acid out of reach of children so that they don't accidentally take it. If your child took iron/folic acid and you notice them vomiting up blood or having diarrhea and stomach pain, call your local Poison Control Center right away at 1-800-222-1222.
Iron/folic acid can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Taking too much iron | Receiving multiple blood transfusions | Medical problems that raise your blood iron level | Children under 6 years of age
If you take multiple supplements that contain iron or take more iron/folic acid than recommended, there's a chance that your iron level will become too high. This is dangerous because it can lead to problems such as tears in the gut, seizures, and liver damage. Your provider will regularly do blood tests to check your iron level while you're taking iron/folic acid. Let your provider know right away if you experience symptoms of too much iron, such as nausea, vomiting, stomach pain, and diarrhea.
Accidental overdose of iron-containing products, like iron/folic acid, can be extremely harmful to children under 6 years of age. Keep iron/folic acid out of reach of children so that they don't accidentally take it. If your child took iron/folic acid and you notice them vomiting up blood or having diarrhea and stomach pain, call your local Poison Control Center right away at 1-800-222-1222.
Taking folic acid can sometimes hide anemia due to low vitamin B12 levels. This means that folic acid might help raise your red blood cell count without addressing your vitamin B12 levels, which can remain low. Your provider might check your vitamin B12 levels through blood work before you start folic acid to make sure you receive appropriate treatment for all your nutrient deficiencies.
Dosage | Quantity | Price as low as | Price per unit |
---|---|---|---|
1mg/12mg | 90 tablets | $57.88 | $0.64 |
Different brand names of iron/folic acid can have different forms of iron, strengths of iron and folic acid, and directions. Please read the manufacturer's label of your product for directions specific to the brand-name medication you're taking.
Examples of iron/folic acid include:
Bentivite: Each tablet contains 35 mg of iron (from ferrous sulfate) and 1 mg of folic acid. The typical dose is 1 tablet by mouth once or twice daily.
ProFerrin Forte: Each tablet contains 12 mg of iron (as Proferrin® heme iron polypeptide) and 1 mg of folic acid. The typical dose is 1 tablet by mouth up to three times daily.
Conditions that cause high iron levels (e.g., hemochromatosis)
Taking Bentivite together with mineral oil
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Colorado Biolabs. (n.d.). Proferrin® Forte 90ct.
Lifsa Drugs LLC. (2021). Bentivite- iron (as ferrous sulfate) and folic tablet [package insert]. DailyMed.
MedlinePlus. (2023). Taking iron supplements.
National Heart, Lung, and Blood Institute. (2022). Vitamin B12–deficiency anemia.
National Institute of Diabetes and Digestive and Kidney Diseases. (2020). Hemochromatosis.
National Institute of Health, Office of Dietary Supplements. (2023). Iron: Fact sheet for health professionals.
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U.S. Food and Drug Administration. (2022). FDA 101: Dietary supplements.
Yuen, H. W., et al. (2023). Iron toxicity. StatPearls.
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